FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313245599> ?p ?o ?g. }

• W4313245599 endingPage "32" @default.
• W4313245599 startingPage "32" @default.
• W4313245599 abstract "ACOG Committee Opinion #797 proposed intrapartum vancomycin dosing guidelines in the absence of thorough evaluation of its risk versus benefit profile on the maternal and neonatal systems. The previously published serum and cord-blood concentration-time data of vancomycin given to mothers in the intrapartum period was analyzed in this work with a two-compartment pharmacokinetic (PK) model. Monte Carlo simulation was used to establish exposure for the studied population for doses of 1000 mg to 2000 mg every 8 h for gestational ages (GA) of 33 to 40 weeks and for birth times up to 4-h intervals. Probabilities of target attainment (PTA) were calculated for efficacy and toxicity indices unique to the peripartum maternal and neonatal population. Neonatal evaluations indicate uniformly high PTAs for the evaluated dosing regimens when the efficacy target is considered. On the other hand, the PTAs for potentially nephrotoxic exposure is expected to reach undesirable levels when three or more doses were to be administered. The risk is profoundly high in GA below 36 weeks and birth times beyond 20 h after the initiation of intrapartum prophylaxis and with doses greater than 1250 mg. Maternal vancomycin exposures seem reasonable up to two intrapartum doses given at 8 h intervals when the dose is kept to 1250 mg or less. Most mothers (up to 83%) who receive three or more doses of the commonly administered regimens are subjected to nephrotoxic exposures. Thus, it appears that the current recommendations by #797 for dosing of vancomycin pose considerable risk to mother and newborn alike, especially in cases with lengthy duration of preterm labor. Capping of doses at 1250 mg may be considered to minimize the need for therapeutic drug monitoring (TDM) interventions. Alternatively, and irrespective of the baseline maternal renal function, TDM for all cases requiring more than two doses of 1500 mg or higher must be assured." @default.
• W4313245599 created "2023-01-06" @default.
• W4313245599 creator A5042693942 @default.
• W4313245599 creator A5057643460 @default.
• W4313245599 date "2022-12-25" @default.
• W4313245599 modified "2023-10-16" @default.
• W4313245599 title "Sorting Out the Risks and Benefits of the #797 Recommended Intrapartum Vancomycin Dosing Approach" @default.
• W4313245599 cites W1638474982 @default.
• W4313245599 cites W1974280087 @default.
• W4313245599 cites W1990758521 @default.
• W4313245599 cites W2002917627 @default.
• W4313245599 cites W2021298363 @default.
• W4313245599 cites W2021615277 @default.
• W4313245599 cites W2026217334 @default.
• W4313245599 cites W2029351635 @default.
• W4313245599 cites W2062001188 @default.
• W4313245599 cites W2076425177 @default.
• W4313245599 cites W2076664566 @default.
• W4313245599 cites W2103750206 @default.
• W4313245599 cites W2106356304 @default.
• W4313245599 cites W2118089099 @default.
• W4313245599 cites W2118509587 @default.
• W4313245599 cites W2121479996 @default.
• W4313245599 cites W2126893880 @default.
• W4313245599 cites W2129543141 @default.
• W4313245599 cites W2148274472 @default.
• W4313245599 cites W2150760368 @default.
• W4313245599 cites W2151907467 @default.
• W4313245599 cites W2160244430 @default.
• W4313245599 cites W2587595880 @default.
• W4313245599 cites W2594754468 @default.
• W4313245599 cites W2901599573 @default.
• W4313245599 cites W3012260518 @default.
• W4313245599 cites W3015571355 @default.
• W4313245599 cites W3045967604 @default.
• W4313245599 cites W4253650975 @default.
• W4313245599 doi "https://doi.org/10.3390/antibiotics12010032" @default.
• W4313245599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36671234" @default.
• W4313245599 hasPublicationYear "2022" @default.
• W4313245599 type Work @default.
• W4313245599 citedByCount "0" @default.
• W4313245599 crossrefType "journal-article" @default.
• W4313245599 hasAuthorship W4313245599A5042693942 @default.
• W4313245599 hasAuthorship W4313245599A5057643460 @default.
• W4313245599 hasBestOaLocation W43132455991 @default.
• W4313245599 hasConcept C112705442 @default.
• W4313245599 hasConcept C126189478 @default.
• W4313245599 hasConcept C126322002 @default.
• W4313245599 hasConcept C131872663 @default.
• W4313245599 hasConcept C187212893 @default.
• W4313245599 hasConcept C2777288759 @default.
• W4313245599 hasConcept C2778376644 @default.
• W4313245599 hasConcept C2778980435 @default.
• W4313245599 hasConcept C2779234561 @default.
• W4313245599 hasConcept C2779489039 @default.
• W4313245599 hasConcept C2908647359 @default.
• W4313245599 hasConcept C29730261 @default.
• W4313245599 hasConcept C523546767 @default.
• W4313245599 hasConcept C54355233 @default.
• W4313245599 hasConcept C71924100 @default.
• W4313245599 hasConcept C86803240 @default.
• W4313245599 hasConcept C98274493 @default.
• W4313245599 hasConcept C99454951 @default.
• W4313245599 hasConceptScore W4313245599C112705442 @default.
• W4313245599 hasConceptScore W4313245599C126189478 @default.
• W4313245599 hasConceptScore W4313245599C126322002 @default.
• W4313245599 hasConceptScore W4313245599C131872663 @default.
• W4313245599 hasConceptScore W4313245599C187212893 @default.
• W4313245599 hasConceptScore W4313245599C2777288759 @default.
• W4313245599 hasConceptScore W4313245599C2778376644 @default.
• W4313245599 hasConceptScore W4313245599C2778980435 @default.
• W4313245599 hasConceptScore W4313245599C2779234561 @default.
• W4313245599 hasConceptScore W4313245599C2779489039 @default.
• W4313245599 hasConceptScore W4313245599C2908647359 @default.
• W4313245599 hasConceptScore W4313245599C29730261 @default.
• W4313245599 hasConceptScore W4313245599C523546767 @default.
• W4313245599 hasConceptScore W4313245599C54355233 @default.
• W4313245599 hasConceptScore W4313245599C71924100 @default.
• W4313245599 hasConceptScore W4313245599C86803240 @default.
• W4313245599 hasConceptScore W4313245599C98274493 @default.
• W4313245599 hasConceptScore W4313245599C99454951 @default.
• W4313245599 hasIssue "1" @default.
• W4313245599 hasLocation W43132455991 @default.
• W4313245599 hasLocation W43132455992 @default.
• W4313245599 hasLocation W43132455993 @default.
• W4313245599 hasOpenAccess W4313245599 @default.
• W4313245599 hasPrimaryLocation W43132455991 @default.
• W4313245599 hasRelatedWork W1524446842 @default.
• W4313245599 hasRelatedWork W1752358168 @default.
• W4313245599 hasRelatedWork W1887075351 @default.
• W4313245599 hasRelatedWork W2040369435 @default.
• W4313245599 hasRelatedWork W2078727847 @default.
• W4313245599 hasRelatedWork W2175132768 @default.
• W4313245599 hasRelatedWork W2486703553 @default.
• W4313245599 hasRelatedWork W2734593134 @default.
• W4313245599 hasRelatedWork W2982184600 @default.
• W4313245599 hasRelatedWork W4303193234 @default.
• W4313245599 hasVolume "12" @default.

• next