Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313246626> ?p ?o ?g. }
- W4313246626 endingPage "264" @default.
- W4313246626 startingPage "264" @default.
- W4313246626 abstract "One of the major mediators of neuroinflammation in PD is tumour necrosis factor alpha (TNF-α), which, similar to other cytokines, is produced by activated microglia and astrocytes. Although TNF-α can be neuroprotective in the brain, long-term neuroinflammation and TNF release can be harmful, having a neurotoxic role that leads to death of oligodendrocytes, astrocytes, and neurons and, therefore, is associated with neurodegeneration. Apart from cytokines, a wide family of molecules with homologous structures, namely chemokines, play a key role in neuro-inflammation by drawing cytotoxic T-lymphocytes and activating microglia. The objective of the current study was to examine the levels of the serum TNF-α and CCL2 (Chemokine (C-C motif) ligand 2), also known as MCP-1 (Monocyte Chemoattractant Protein-1), in PD patients compared with healthy controls. We also investigated the associations between the serum levels of these two inflammatory mediators and a number of clinical symptoms, in particular, disease severity and cognition. Such an assessment may point to their prognostic value and provide some treatment hints. PD patients with advanced stage on the Hoehn-Yahr scale showed an increase in TNF-α levels compared with PD patients with stages 1 and 2 (p = 0.01). Additionally, the UPDRS score was significantly associated with TNF-α levels. CCL2 levels, however, showed no significant associations." @default.
- W4313246626 created "2023-01-06" @default.
- W4313246626 creator A5014403258 @default.
- W4313246626 creator A5015590373 @default.
- W4313246626 creator A5016668969 @default.
- W4313246626 creator A5020623639 @default.
- W4313246626 creator A5021075951 @default.
- W4313246626 creator A5034606368 @default.
- W4313246626 creator A5062847930 @default.
- W4313246626 creator A5072527666 @default.
- W4313246626 creator A5075785747 @default.
- W4313246626 creator A5082105636 @default.
- W4313246626 date "2022-12-23" @default.
- W4313246626 modified "2023-09-30" @default.
- W4313246626 title "Peripheral Inflammatory Markers TNF-α and CCL2 Revisited: Association with Parkinson’s Disease Severity" @default.
- W4313246626 cites W1833373503 @default.
- W4313246626 cites W1982207977 @default.
- W4313246626 cites W2000580759 @default.
- W4313246626 cites W2018632030 @default.
- W4313246626 cites W2027861239 @default.
- W4313246626 cites W2055750901 @default.
- W4313246626 cites W2056171390 @default.
- W4313246626 cites W2064963539 @default.
- W4313246626 cites W2064996887 @default.
- W4313246626 cites W2069360612 @default.
- W4313246626 cites W2078253393 @default.
- W4313246626 cites W2099386607 @default.
- W4313246626 cites W2103336276 @default.
- W4313246626 cites W2107646604 @default.
- W4313246626 cites W2140978740 @default.
- W4313246626 cites W2155671194 @default.
- W4313246626 cites W2191467661 @default.
- W4313246626 cites W2233667077 @default.
- W4313246626 cites W2328816432 @default.
- W4313246626 cites W2525903933 @default.
- W4313246626 cites W2558041282 @default.
- W4313246626 cites W2567427846 @default.
- W4313246626 cites W2605552557 @default.
- W4313246626 cites W2613492389 @default.
- W4313246626 cites W2621765209 @default.
- W4313246626 cites W2748514674 @default.
- W4313246626 cites W2749718288 @default.
- W4313246626 cites W2773237281 @default.
- W4313246626 cites W2890498338 @default.
- W4313246626 cites W2903888966 @default.
- W4313246626 cites W2906633618 @default.
- W4313246626 cites W2922712727 @default.
- W4313246626 cites W2978315680 @default.
- W4313246626 cites W3007584245 @default.
- W4313246626 cites W3012163045 @default.
- W4313246626 cites W3020404326 @default.
- W4313246626 cites W3022628169 @default.
- W4313246626 cites W3042363707 @default.
- W4313246626 cites W3044513361 @default.
- W4313246626 cites W3046869259 @default.
- W4313246626 cites W3089790353 @default.
- W4313246626 cites W3125904724 @default.
- W4313246626 cites W3126400801 @default.
- W4313246626 cites W3182962217 @default.
- W4313246626 cites W3211714784 @default.
- W4313246626 cites W3212072621 @default.
- W4313246626 cites W4220735064 @default.
- W4313246626 cites W4221068851 @default.
- W4313246626 cites W4249796501 @default.
- W4313246626 cites W4281931196 @default.
- W4313246626 doi "https://doi.org/10.3390/ijms24010264" @default.
- W4313246626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36613708" @default.
- W4313246626 hasPublicationYear "2022" @default.
- W4313246626 type Work @default.
- W4313246626 citedByCount "5" @default.
- W4313246626 countsByYear W43132466262023 @default.
- W4313246626 crossrefType "journal-article" @default.
- W4313246626 hasAuthorship W4313246626A5014403258 @default.
- W4313246626 hasAuthorship W4313246626A5015590373 @default.
- W4313246626 hasAuthorship W4313246626A5016668969 @default.
- W4313246626 hasAuthorship W4313246626A5020623639 @default.
- W4313246626 hasAuthorship W4313246626A5021075951 @default.
- W4313246626 hasAuthorship W4313246626A5034606368 @default.
- W4313246626 hasAuthorship W4313246626A5062847930 @default.
- W4313246626 hasAuthorship W4313246626A5072527666 @default.
- W4313246626 hasAuthorship W4313246626A5075785747 @default.
- W4313246626 hasAuthorship W4313246626A5082105636 @default.
- W4313246626 hasBestOaLocation W43132466261 @default.
- W4313246626 hasConcept C101666144 @default.
- W4313246626 hasConcept C126322002 @default.
- W4313246626 hasConcept C13373296 @default.
- W4313246626 hasConcept C164027704 @default.
- W4313246626 hasConcept C17991360 @default.
- W4313246626 hasConcept C203014093 @default.
- W4313246626 hasConcept C25498285 @default.
- W4313246626 hasConcept C2776914184 @default.
- W4313246626 hasConcept C2776925932 @default.
- W4313246626 hasConcept C2779134260 @default.
- W4313246626 hasConcept C2779830541 @default.
- W4313246626 hasConcept C2781184567 @default.
- W4313246626 hasConcept C71924100 @default.
- W4313246626 hasConcept C87753298 @default.
- W4313246626 hasConceptScore W4313246626C101666144 @default.