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- W4313247165 abstract "Parkinson's disease (PD) is a dopaminergic neuron-related neurodegenerative illness. Treatments exist that alleviate symptoms but have a variety of negative effects. Recent research has revealed that oxidative stress, along with neuroinflammation, is a major factor in the course of this disease. Therefore, the aim of our study was to observe for the first time the effects of a natural compound such as Actaea racemosa L. rhizome in an in vivo model of PD induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). For the study, mice received four injections of MPTP (20 mg/kg) for the induction of PD. Starting 24 h after the first administration of MPTP we treated mice with Actaea racemosa L. rhizome (100 mg/kg) daily for seven days. Our findings clearly demonstrated that Actaea racemosa L. rhizome treatment decreases oxidative stress by activating redox balance enzymes such as Nrf2/HO-1. We also demonstrated that Actaea racemosa L. rhizome is capable of modulating inflammatory indicators involved in PD, such as IκB-α, NF-κB, GFAP and Iba1, thus reducing the degeneration of dopaminergic neurons and motor and non-motor alterations. To summarize, Actaea racemosa L. rhizome, which is subject to fewer regulations than traditional medications, could be used as a dietary supplement to improve patients' brain health and could be a promising nutraceutical choice to slow the course and symptoms of PD." @default.
- W4313247165 created "2023-01-06" @default.
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- W4313247165 date "2022-12-25" @default.
- W4313247165 modified "2023-10-04" @default.
- W4313247165 title "Actaea racemosa L. Rhizome Protect against MPTP-Induced Neurotoxicity in Mice by Modulating Oxidative Stress and Neuroinflammation" @default.
- W4313247165 cites W1480184530 @default.
- W4313247165 cites W1602409385 @default.
- W4313247165 cites W1902695739 @default.
- W4313247165 cites W1969800514 @default.
- W4313247165 cites W1977817564 @default.
- W4313247165 cites W1991018010 @default.
- W4313247165 cites W1992033043 @default.
- W4313247165 cites W1992123323 @default.
- W4313247165 cites W1996014444 @default.
- W4313247165 cites W1997253394 @default.
- W4313247165 cites W2000178617 @default.
- W4313247165 cites W2002291923 @default.
- W4313247165 cites W2002703101 @default.
- W4313247165 cites W2005594217 @default.
- W4313247165 cites W2010072042 @default.
- W4313247165 cites W2020471990 @default.
- W4313247165 cites W2020632156 @default.
- W4313247165 cites W2023879799 @default.
- W4313247165 cites W2026386768 @default.
- W4313247165 cites W2032588521 @default.
- W4313247165 cites W2040709788 @default.
- W4313247165 cites W2041561931 @default.
- W4313247165 cites W2042645417 @default.
- W4313247165 cites W2044399199 @default.
- W4313247165 cites W2045340028 @default.
- W4313247165 cites W2047381370 @default.
- W4313247165 cites W2052829501 @default.
- W4313247165 cites W2072727206 @default.
- W4313247165 cites W2073449985 @default.
- W4313247165 cites W2073688363 @default.
- W4313247165 cites W2085270307 @default.
- W4313247165 cites W2086377589 @default.
- W4313247165 cites W2114049362 @default.
- W4313247165 cites W2133781730 @default.
- W4313247165 cites W2140191831 @default.
- W4313247165 cites W2142208636 @default.
- W4313247165 cites W2166911020 @default.
- W4313247165 cites W2189645607 @default.
- W4313247165 cites W2309675626 @default.
- W4313247165 cites W2331942228 @default.
- W4313247165 cites W2340147290 @default.
- W4313247165 cites W2471345196 @default.
- W4313247165 cites W2523579641 @default.
- W4313247165 cites W2584311212 @default.
- W4313247165 cites W2600495731 @default.
- W4313247165 cites W2604526488 @default.
- W4313247165 cites W2617413767 @default.
- W4313247165 cites W2725119441 @default.
- W4313247165 cites W2751469159 @default.
- W4313247165 cites W2767765728 @default.
- W4313247165 cites W2790061585 @default.
- W4313247165 cites W2795068775 @default.
- W4313247165 cites W2797560790 @default.
- W4313247165 cites W2811315997 @default.
- W4313247165 cites W2884181644 @default.
- W4313247165 cites W2901508988 @default.
- W4313247165 cites W2903367726 @default.
- W4313247165 cites W2909533094 @default.
- W4313247165 cites W2951992845 @default.
- W4313247165 cites W2955203652 @default.
- W4313247165 cites W2988223062 @default.
- W4313247165 cites W2990667221 @default.
- W4313247165 cites W2993165323 @default.
- W4313247165 cites W2999060661 @default.
- W4313247165 cites W3012427018 @default.
- W4313247165 cites W3016614566 @default.
- W4313247165 cites W3026444499 @default.
- W4313247165 cites W3036084153 @default.
- W4313247165 cites W3044342387 @default.
- W4313247165 cites W3080803337 @default.
- W4313247165 cites W3081658086 @default.
- W4313247165 cites W3121849107 @default.
- W4313247165 cites W3135374216 @default.
- W4313247165 cites W3172925917 @default.
- W4313247165 cites W3174805668 @default.
- W4313247165 cites W3176009726 @default.
- W4313247165 cites W3176834099 @default.
- W4313247165 cites W3177057172 @default.
- W4313247165 cites W3183303755 @default.
- W4313247165 cites W3192348655 @default.