Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313247329> ?p ?o ?g. }
- W4313247329 endingPage "70" @default.
- W4313247329 startingPage "70" @default.
- W4313247329 abstract "Several genes associated with periodontitis have been identified through genome-wide association studies (GWAS); however, known genes only explain a minority of the estimated heritability. We aimed to explore more susceptibility genes and the underlying mechanisms of periodontitis. Firstly, a genome-wide meta-analysis of 38,532 patients and 316,185 healthy controls was performed. Then, cross- and single-tissue transcriptome-wide association studies (TWAS) were conducted based on GWAS summary statistics and the Genotype-Tissue Expression (GTEx) project. Risk genes were evaluated to determine if they were differentially expressed in periodontitis sites compared with unaffected sites using public datasets. Finally, gene co-expression network analysis was conducted to identify the functional biology of the susceptible genes. A total of eight single nucleotide polymorphisms (SNPs) within the introns of lncRNA LINC02141 approached genome-wide significance after meta-analysis. EZH1 was identified as a novel susceptibility gene for periodontitis by TWAS and was significantly upregulated in periodontitis-affected gingival tissues. EZH1 co-expression genes were greatly enriched in the cell-substrate junction, focal adhesion and other important pathways. Our findings may offer a fundamental clue for comprehending the genetic mechanisms of periodontitis." @default.
- W4313247329 created "2023-01-06" @default.
- W4313247329 creator A5018977357 @default.
- W4313247329 creator A5039614440 @default.
- W4313247329 creator A5053275663 @default.
- W4313247329 creator A5059434741 @default.
- W4313247329 creator A5060650677 @default.
- W4313247329 date "2022-12-23" @default.
- W4313247329 modified "2023-10-18" @default.
- W4313247329 title "Genome- and Transcriptome-Wide Association Studies Identify Susceptibility Genes and Pathways for Periodontitis" @default.
- W4313247329 cites W1930554906 @default.
- W4313247329 cites W1970129984 @default.
- W4313247329 cites W1973455669 @default.
- W4313247329 cites W1999182495 @default.
- W4313247329 cites W2001492139 @default.
- W4313247329 cites W2072451811 @default.
- W4313247329 cites W2094038779 @default.
- W4313247329 cites W2117276919 @default.
- W4313247329 cites W2127434913 @default.
- W4313247329 cites W2133520037 @default.
- W4313247329 cites W2163013660 @default.
- W4313247329 cites W2195359644 @default.
- W4313247329 cites W2209106767 @default.
- W4313247329 cites W2248907500 @default.
- W4313247329 cites W2264585211 @default.
- W4313247329 cites W2328393125 @default.
- W4313247329 cites W2559028527 @default.
- W4313247329 cites W2608697147 @default.
- W4313247329 cites W2608813759 @default.
- W4313247329 cites W2759086237 @default.
- W4313247329 cites W2761275051 @default.
- W4313247329 cites W2801470635 @default.
- W4313247329 cites W2809048536 @default.
- W4313247329 cites W2809948294 @default.
- W4313247329 cites W2889729381 @default.
- W4313247329 cites W2890823271 @default.
- W4313247329 cites W2892294576 @default.
- W4313247329 cites W2894860301 @default.
- W4313247329 cites W2897493779 @default.
- W4313247329 cites W2914643350 @default.
- W4313247329 cites W2918064359 @default.
- W4313247329 cites W2944540884 @default.
- W4313247329 cites W2945665018 @default.
- W4313247329 cites W2945780191 @default.
- W4313247329 cites W2950235747 @default.
- W4313247329 cites W2956258410 @default.
- W4313247329 cites W2984719377 @default.
- W4313247329 cites W3004666264 @default.
- W4313247329 cites W3011774599 @default.
- W4313247329 cites W3023972696 @default.
- W4313247329 cites W3025230350 @default.
- W4313247329 cites W3106733797 @default.
- W4313247329 cites W3110567601 @default.
- W4313247329 cites W3123077035 @default.
- W4313247329 cites W3157863094 @default.
- W4313247329 cites W3159722397 @default.
- W4313247329 cites W3175752499 @default.
- W4313247329 cites W4200452424 @default.
- W4313247329 cites W4205285691 @default.
- W4313247329 cites W4211223324 @default.
- W4313247329 cites W4220966186 @default.
- W4313247329 cites W4224286353 @default.
- W4313247329 cites W4230233764 @default.
- W4313247329 cites W4283739603 @default.
- W4313247329 cites W4285077433 @default.
- W4313247329 doi "https://doi.org/10.3390/cells12010070" @default.
- W4313247329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36611863" @default.
- W4313247329 hasPublicationYear "2022" @default.
- W4313247329 type Work @default.
- W4313247329 citedByCount "2" @default.
- W4313247329 countsByYear W43132473292023 @default.
- W4313247329 crossrefType "journal-article" @default.
- W4313247329 hasAuthorship W4313247329A5018977357 @default.
- W4313247329 hasAuthorship W4313247329A5039614440 @default.
- W4313247329 hasAuthorship W4313247329A5053275663 @default.
- W4313247329 hasAuthorship W4313247329A5059434741 @default.
- W4313247329 hasAuthorship W4313247329A5060650677 @default.
- W4313247329 hasBestOaLocation W43132473291 @default.
- W4313247329 hasConcept C104317684 @default.
- W4313247329 hasConcept C106208931 @default.
- W4313247329 hasConcept C126322002 @default.
- W4313247329 hasConcept C135763542 @default.
- W4313247329 hasConcept C141231307 @default.
- W4313247329 hasConcept C150194340 @default.
- W4313247329 hasConcept C153209595 @default.
- W4313247329 hasConcept C162317418 @default.
- W4313247329 hasConcept C186413461 @default.
- W4313247329 hasConcept C2780385504 @default.
- W4313247329 hasConcept C54355233 @default.
- W4313247329 hasConcept C70721500 @default.
- W4313247329 hasConcept C71924100 @default.
- W4313247329 hasConcept C86803240 @default.
- W4313247329 hasConceptScore W4313247329C104317684 @default.
- W4313247329 hasConceptScore W4313247329C106208931 @default.
- W4313247329 hasConceptScore W4313247329C126322002 @default.
- W4313247329 hasConceptScore W4313247329C135763542 @default.
- W4313247329 hasConceptScore W4313247329C141231307 @default.
- W4313247329 hasConceptScore W4313247329C150194340 @default.