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• W4313248791 abstract "Advances in ultrasensitive detection of phosphorylated tau (p-tau) in plasma has enabled the use of blood tests to measure Alzheimer's disease (AD) biomarker changes. Examination of postmortem brains of participants with antemortem plasma p-tau levels remains critical to understanding comorbid and AD-specific contribution to these biomarker changes.We analyzed 35 population-based Mayo Clinic Study of Aging participants with plasma p-tau at threonine 181 and threonine 217 (p-tau181, p-tau217) available within 3 years of death. Autopsied participants included cognitively unimpaired, mild cognitive impairment, AD dementia, and non-AD neurodegenerative disorders. Global neuropathologic scales of tau, amyloid-β, TDP-43, and cerebrovascular disease were examined. Regional digital pathology measures of tau (phosphorylated threonine 181 and 217 [pT181, pT217]) and amyloid-β (6F/3D) were quantified in hippocampus and parietal cortex. Neurotransmitter hubs reported to influence development of tangles (nucleus basalis of Meynert) and amyloid-β plaques (locus coeruleus) were evaluated.The strongest regional associations were with parietal cortex for tau burden (p-tau181 R = 0.55, p = 0.003; p-tau217 R = 0.66, p < 0.001) and amyloid-β burden (p-tau181 R = 0.59, p < 0.001; p-tau217 R = 0.71, p < 0.001). Linear regression analysis of global neuropathologic scales explained 31% of variability in plasma p-tau181 (Adj. R2 = 0.31) and 59% in plasma p-tau217 (Adj. R2 = 0.59). Neither TDP-43 nor cerebrovascular disease global scales independently contributed to variability. Global scales of tau pathology (β-coefficient = 0.060, p = 0.016) and amyloid-β pathology (β-coefficient = 0.080, p < 0.001) independently predicted plasma p-tau217 when modeled together with co-pathologies, but only amyloid-β (β-coefficient = 0.33, p = 0.021) significantly predicted plasma p-tau181. While nucleus basalis of Meynert neuron count/mm2 was not associated with plasma p-tau levels, a lower locus coeruleus neuron count/mm2 was associated with higher plasma p-tau181 (R = -0.50, p = 0.007) and higher plasma p-tau217 (R = -0.55, p = 0.002). Cognitive scores (Adj. R2 = 0.25-0.32) were predicted by the global tau scale, but not by the global amyloid-β scale or plasma p-tau when modeled simultaneously.Higher soluble plasma p-tau levels may be the result of an intersection between insoluble deposits of amyloid-β and tau accumulation in brain, and may be associated with locus coeruleus degeneration." @default.
• W4313248791 created "2023-01-06" @default.
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• W4313248791 date "2022-12-27" @default.
• W4313248791 modified "2023-09-29" @default.
• W4313248791 title "Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels" @default.
• W4313248791 cites W1820013501 @default.
• W4313248791 cites W1847168837 @default.
• W4313248791 cites W1967823816 @default.
• W4313248791 cites W1971032265 @default.
• W4313248791 cites W1991952617 @default.
• W4313248791 cites W1993023011 @default.
• W4313248791 cites W2008854521 @default.
• W4313248791 cites W2014601504 @default.
• W4313248791 cites W2020780341 @default.
• W4313248791 cites W2039220230 @default.
• W4313248791 cites W2048685634 @default.
• W4313248791 cites W2052742260 @default.
• W4313248791 cites W2058161128 @default.
• W4313248791 cites W2067772208 @default.
• W4313248791 cites W2068744836 @default.
• W4313248791 cites W2070137740 @default.
• W4313248791 cites W2074274706 @default.
• W4313248791 cites W2081533023 @default.
• W4313248791 cites W2082429191 @default.
• W4313248791 cites W2109742329 @default.
• W4313248791 cites W2124681501 @default.
• W4313248791 cites W2128228199 @default.
• W4313248791 cites W2131180711 @default.
• W4313248791 cites W2146729934 @default.
• W4313248791 cites W2148080316 @default.
• W4313248791 cites W2148457471 @default.
• W4313248791 cites W2159099163 @default.
• W4313248791 cites W2165127832 @default.
• W4313248791 cites W2167311298 @default.
• W4313248791 cites W2168451388 @default.
• W4313248791 cites W2170906442 @default.
• W4313248791 cites W2172053191 @default.
• W4313248791 cites W2400693235 @default.
• W4313248791 cites W2426305809 @default.
• W4313248791 cites W2472346278 @default.
• W4313248791 cites W2605473592 @default.
• W4313248791 cites W2623521763 @default.
• W4313248791 cites W2794390181 @default.
• W4313248791 cites W2795642715 @default.
• W4313248791 cites W2805964755 @default.
• W4313248791 cites W2806938337 @default.
• W4313248791 cites W2897964327 @default.
• W4313248791 cites W2943828894 @default.
• W4313248791 cites W2962866038 @default.
• W4313248791 cites W2964512741 @default.
• W4313248791 cites W2966029669 @default.
• W4313248791 cites W2968840243 @default.
• W4313248791 cites W2981642494 @default.
• W4313248791 cites W2991594523 @default.
• W4313248791 cites W3009441391 @default.
• W4313248791 cites W3009833354 @default.
• W4313248791 cites W3018431352 @default.
• W4313248791 cites W3044633524 @default.
• W4313248791 cites W3045997188 @default.
• W4313248791 cites W3102160053 @default.
• W4313248791 cites W3108125496 @default.
• W4313248791 cites W3120576328 @default.
• W4313248791 cites W3126187484 @default.
• W4313248791 cites W3128184462 @default.
• W4313248791 cites W3131174931 @default.
• W4313248791 cites W3135004658 @default.
• W4313248791 cites W3146341767 @default.
• W4313248791 cites W3181997110 @default.
• W4313248791 cites W3183927686 @default.
• W4313248791 cites W3194829575 @default.
• W4313248791 cites W3200931809 @default.
• W4313248791 cites W4200216333 @default.
• W4313248791 cites W4206731714 @default.
• W4313248791 cites W4214927511 @default.
• W4313248791 cites W4225589542 @default.
• W4313248791 cites W4281558685 @default.
• W4313248791 cites W4285587164 @default.
• W4313248791 cites W4289711479 @default.
• W4313248791 cites W4292865371 @default.

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