FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313249625> ?p ?o ?g. }

• W4313249625 endingPage "17" @default.
• W4313249625 startingPage "1" @default.
• W4313249625 abstract "Lung cancer is a leading global cause of cancer-related death in both males and females. Non-small-cell lung cancer (NSCLC) is the most commonly diagnosed cancer type that can be difficult to control with conventional chemotherapeutic and surgical approaches resulting in a poor prognosis. Paclitaxel (PTX) is a commonly used chemotherapeutic drug for NSCLC, which can cause tissue injury in healthy cells and affect the quality of life in patients with cancer. In order to treat NSCLC, alternative medications with minimal or no side effects are highly needed. Ononin is an isoflavone glycoside extracted from Astragali Radix (AR) that has various pharmacological activities. Therefore, this study investigated whether ononin inhibits NSCLC progression and promotes apoptosis synergistically with PTX both in vitro and in vivo. Antitumorigenic properties of ononin were determined by MTT assay, colony formation assay, migratory capacity, and apoptotic marker expression in A549 and HCC827 cells. The combination of ononin with PTX increased the expression of apoptotic markers and ROS generation and inhibited cell proliferation through the PI3K/Akt/mTOR signaling pathways. Furthermore, ononin prevented the translocation of NF-κB from cytosol to the nucleus. Also, we used the xenograft NSCLC mice model to confirm the in vivo antitumorigenic efficacies of ononin by reduction of CD34 and Ki67 expressions. Based on the histological analysis, the cotreatment of PTX and ononin reduced PTX-induced liver and kidney damage. Overall, our findings suggested that the therapeutic index of PTX-based chemotherapy could be improved by reducing toxicity with increasing antitumor capabilities when combined with ononin." @default.
• W4313249625 created "2023-01-06" @default.
• W4313249625 creator A5023168600 @default.
• W4313249625 creator A5047109460 @default.
• W4313249625 creator A5056217442 @default.
• W4313249625 creator A5069665854 @default.
• W4313249625 date "2022-12-27" @default.
• W4313249625 modified "2023-10-14" @default.
• W4313249625 title "Antitumor Effects of Ononin by Modulation of Apoptosis in Non-Small-Cell Lung Cancer through Inhibiting PI3K/Akt/mTOR Pathway" @default.
• W4313249625 cites W1548882558 @default.
• W4313249625 cites W1965149502 @default.
• W4313249625 cites W2005829193 @default.
• W4313249625 cites W2037877889 @default.
• W4313249625 cites W2123016548 @default.
• W4313249625 cites W2128259512 @default.
• W4313249625 cites W2284891209 @default.
• W4313249625 cites W2334700441 @default.
• W4313249625 cites W2521727246 @default.
• W4313249625 cites W2585405606 @default.
• W4313249625 cites W2610779774 @default.
• W4313249625 cites W2621333085 @default.
• W4313249625 cites W2735590725 @default.
• W4313249625 cites W2755196285 @default.
• W4313249625 cites W2766272450 @default.
• W4313249625 cites W2767464756 @default.
• W4313249625 cites W2790040504 @default.
• W4313249625 cites W2802491818 @default.
• W4313249625 cites W2895287870 @default.
• W4313249625 cites W2914143786 @default.
• W4313249625 cites W2943921906 @default.
• W4313249625 cites W2952998155 @default.
• W4313249625 cites W2965203310 @default.
• W4313249625 cites W2967678206 @default.
• W4313249625 cites W2991274658 @default.
• W4313249625 cites W3004777643 @default.
• W4313249625 cites W3015529274 @default.
• W4313249625 cites W3017886628 @default.
• W4313249625 cites W3027995036 @default.
• W4313249625 cites W3099092441 @default.
• W4313249625 cites W3118556156 @default.
• W4313249625 cites W3119952098 @default.
• W4313249625 cites W3128520866 @default.
• W4313249625 cites W3129161663 @default.
• W4313249625 cites W3155376330 @default.
• W4313249625 cites W3162485365 @default.
• W4313249625 cites W3163952303 @default.
• W4313249625 cites W3165986740 @default.
• W4313249625 cites W3192871807 @default.
• W4313249625 cites W3199246922 @default.
• W4313249625 cites W3202560731 @default.
• W4313249625 cites W3203864001 @default.
• W4313249625 cites W4285495166 @default.
• W4313249625 cites W4288735292 @default.
• W4313249625 cites W4288988468 @default.
• W4313249625 doi "https://doi.org/10.1155/2022/5122448" @default.
• W4313249625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36605098" @default.
• W4313249625 hasPublicationYear "2022" @default.
• W4313249625 type Work @default.
• W4313249625 citedByCount "5" @default.
• W4313249625 countsByYear W43132496252023 @default.
• W4313249625 crossrefType "journal-article" @default.
• W4313249625 hasAuthorship W4313249625A5023168600 @default.
• W4313249625 hasAuthorship W4313249625A5047109460 @default.
• W4313249625 hasAuthorship W4313249625A5056217442 @default.
• W4313249625 hasAuthorship W4313249625A5069665854 @default.
• W4313249625 hasBestOaLocation W43132496251 @default.
• W4313249625 hasConcept C121608353 @default.
• W4313249625 hasConcept C126322002 @default.
• W4313249625 hasConcept C143998085 @default.
• W4313249625 hasConcept C150903083 @default.
• W4313249625 hasConcept C190283241 @default.
• W4313249625 hasConcept C207001950 @default.
• W4313249625 hasConcept C2776256026 @default.
• W4313249625 hasConcept C2777292972 @default.
• W4313249625 hasConcept C502942594 @default.
• W4313249625 hasConcept C55493867 @default.
• W4313249625 hasConcept C71924100 @default.
• W4313249625 hasConcept C75217442 @default.
• W4313249625 hasConcept C86554907 @default.
• W4313249625 hasConcept C86803240 @default.
• W4313249625 hasConcept C98274493 @default.
• W4313249625 hasConceptScore W4313249625C121608353 @default.
• W4313249625 hasConceptScore W4313249625C126322002 @default.
• W4313249625 hasConceptScore W4313249625C143998085 @default.
• W4313249625 hasConceptScore W4313249625C150903083 @default.
• W4313249625 hasConceptScore W4313249625C190283241 @default.
• W4313249625 hasConceptScore W4313249625C207001950 @default.
• W4313249625 hasConceptScore W4313249625C2776256026 @default.
• W4313249625 hasConceptScore W4313249625C2777292972 @default.
• W4313249625 hasConceptScore W4313249625C502942594 @default.
• W4313249625 hasConceptScore W4313249625C55493867 @default.
• W4313249625 hasConceptScore W4313249625C71924100 @default.
• W4313249625 hasConceptScore W4313249625C75217442 @default.
• W4313249625 hasConceptScore W4313249625C86554907 @default.
• W4313249625 hasConceptScore W4313249625C86803240 @default.
• W4313249625 hasConceptScore W4313249625C98274493 @default.
• W4313249625 hasFunder F4320322769 @default.
• W4313249625 hasLocation W43132496251 @default.

• next