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• W4313249898 abstract "An effective method for synthesis of the active pharmaceutical ingredient epalrestat in continuous or tubular flow circumstances with a high yield and a quick reaction time (10 min) has been reported. The reaction conditions for the aldol condensation reaction under tubular continuous flow technology by controlling light-sensitive degradation impurities was optimized. The developed method was more efficient, environmentally benign, time-economic, energy-saving, cost-efficient and also gives a reduction in process mass intensity in comparison with batch process." @default.
• W4313249898 created "2023-01-06" @default.
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• W4313249898 date "2022-12-27" @default.
• W4313249898 modified "2023-10-11" @default.
• W4313249898 title "Development of Efficient Manufacturing Process for Active Pharmaceutical Ingredient Epalrestat and its Derivatives in Continuous Flow Synthesis" @default.
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• W4313249898 doi "https://doi.org/10.14233/ajchem.2023.24008" @default.
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