FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313250577> ?p ?o ?g. }

• W4313250577 endingPage "e32349" @default.
• W4313250577 startingPage "e32349" @default.
• W4313250577 abstract "Parkinson's disease (PD) is a common irreversible neurodegenerative disease associated with cognitive impairment. To investigate the serum level of phosphatidylinositol-3-kinase (PI3K) and the distribution of the genotypes and alleles of 3 PI3K single-nucleotide polymorphisms (RS37,30,087, RS37,30,088, and RS37,30,089) in PD patients with different clinical characteristics. A total of 54 PD patients and 50 healthy individuals were recruited. The serum PI3K level was measured using the enzyme-linked immunosorbent assay. The severity of PD was assessed using the modified Hoehn-Yahr scale. The cognitive function of PD patients was evaluated using the Mini-Mental State Examination scale and the Montreal Cognitive Assessment. The distribution of the alleles and genotypes of PI3K single-nucleotide polymorphisms (SNPs) was calculated using the Hardy-Weinberg equilibrium. PD patients showed a significantly higher serum level of PI3K compared to healthy individuals. Increased serum PI3K level was observed in PD patients with more severe disease, longer disease duration, and impaired cognitive function. Additionally, no significant differences were observed in the distributions of the genotypes and alleles of 3 PI3K SNPs between PD patients with normal cognitive function and those with cognitive impairment. PD patients with different levels of disease severity, disease duration, and cognitive function had significantly different serum levels of PI3K. However, the PI3K SNPs in patients with normal cognitive function were not significantly different from those in patients with cognitive impairment. These findings contribute to a better understanding of the roles of PI3K and SNPs of the PI3K gene in PD." @default.
• W4313250577 created "2023-01-06" @default.
• W4313250577 creator A5004853365 @default.
• W4313250577 creator A5007581972 @default.
• W4313250577 creator A5011886791 @default.
• W4313250577 creator A5012088434 @default.
• W4313250577 creator A5014253273 @default.
• W4313250577 creator A5017941291 @default.
• W4313250577 creator A5021386750 @default.
• W4313250577 creator A5030534452 @default.
• W4313250577 creator A5036457690 @default.
• W4313250577 creator A5058993912 @default.
• W4313250577 creator A5076093789 @default.
• W4313250577 date "2022-12-23" @default.
• W4313250577 modified "2023-10-16" @default.
• W4313250577 title "PI3K polymorphism in patients with sporadic Parkinson’s disease" @default.
• W4313250577 cites W1969305530 @default.
• W4313250577 cites W1998817804 @default.
• W4313250577 cites W2000073596 @default.
• W4313250577 cites W2039525732 @default.
• W4313250577 cites W2071466153 @default.
• W4313250577 cites W2080136467 @default.
• W4313250577 cites W2108008377 @default.
• W4313250577 cites W2121127591 @default.
• W4313250577 cites W2125461230 @default.
• W4313250577 cites W2130295086 @default.
• W4313250577 cites W2135799619 @default.
• W4313250577 cites W2165758561 @default.
• W4313250577 cites W2167288565 @default.
• W4313250577 cites W2199541585 @default.
• W4313250577 cites W2466677132 @default.
• W4313250577 cites W2485315891 @default.
• W4313250577 cites W2493736035 @default.
• W4313250577 cites W2570634615 @default.
• W4313250577 cites W2765290339 @default.
• W4313250577 cites W2767057706 @default.
• W4313250577 cites W2793678678 @default.
• W4313250577 cites W2914421199 @default.
• W4313250577 cites W2915723917 @default.
• W4313250577 cites W2969956278 @default.
• W4313250577 cites W2999235182 @default.
• W4313250577 cites W3030986437 @default.
• W4313250577 cites W3100558981 @default.
• W4313250577 cites W4211123396 @default.
• W4313250577 doi "https://doi.org/10.1097/md.0000000000032349" @default.
• W4313250577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36595764" @default.
• W4313250577 hasPublicationYear "2022" @default.
• W4313250577 type Work @default.
• W4313250577 citedByCount "0" @default.
• W4313250577 crossrefType "journal-article" @default.
• W4313250577 hasAuthorship W4313250577A5004853365 @default.
• W4313250577 hasAuthorship W4313250577A5007581972 @default.
• W4313250577 hasAuthorship W4313250577A5011886791 @default.
• W4313250577 hasAuthorship W4313250577A5012088434 @default.
• W4313250577 hasAuthorship W4313250577A5014253273 @default.
• W4313250577 hasAuthorship W4313250577A5017941291 @default.
• W4313250577 hasAuthorship W4313250577A5021386750 @default.
• W4313250577 hasAuthorship W4313250577A5030534452 @default.
• W4313250577 hasAuthorship W4313250577A5036457690 @default.
• W4313250577 hasAuthorship W4313250577A5058993912 @default.
• W4313250577 hasAuthorship W4313250577A5076093789 @default.
• W4313250577 hasBestOaLocation W43132505771 @default.
• W4313250577 hasConcept C104317684 @default.
• W4313250577 hasConcept C118552586 @default.
• W4313250577 hasConcept C126322002 @default.
• W4313250577 hasConcept C135763542 @default.
• W4313250577 hasConcept C153209595 @default.
• W4313250577 hasConcept C169900460 @default.
• W4313250577 hasConcept C180754005 @default.
• W4313250577 hasConcept C2776632958 @default.
• W4313250577 hasConcept C2779134260 @default.
• W4313250577 hasConcept C2984915365 @default.
• W4313250577 hasConcept C54355233 @default.
• W4313250577 hasConcept C71924100 @default.
• W4313250577 hasConcept C86803240 @default.
• W4313250577 hasConcept C90924648 @default.
• W4313250577 hasConceptScore W4313250577C104317684 @default.
• W4313250577 hasConceptScore W4313250577C118552586 @default.
• W4313250577 hasConceptScore W4313250577C126322002 @default.
• W4313250577 hasConceptScore W4313250577C135763542 @default.
• W4313250577 hasConceptScore W4313250577C153209595 @default.
• W4313250577 hasConceptScore W4313250577C169900460 @default.
• W4313250577 hasConceptScore W4313250577C180754005 @default.
• W4313250577 hasConceptScore W4313250577C2776632958 @default.
• W4313250577 hasConceptScore W4313250577C2779134260 @default.
• W4313250577 hasConceptScore W4313250577C2984915365 @default.
• W4313250577 hasConceptScore W4313250577C54355233 @default.
• W4313250577 hasConceptScore W4313250577C71924100 @default.
• W4313250577 hasConceptScore W4313250577C86803240 @default.
• W4313250577 hasConceptScore W4313250577C90924648 @default.
• W4313250577 hasIssue "51" @default.
• W4313250577 hasLocation W43132505771 @default.
• W4313250577 hasLocation W43132505772 @default.
• W4313250577 hasLocation W43132505773 @default.
• W4313250577 hasLocation W43132505774 @default.
• W4313250577 hasOpenAccess W4313250577 @default.
• W4313250577 hasPrimaryLocation W43132505771 @default.
• W4313250577 hasRelatedWork W1994630386 @default.

• next