Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313250943> ?p ?o ?g. }
- W4313250943 abstract "Prenatal stress (PS) causes anxiety in mothers and their offspring and chewing is a commonly observed behavior during maternal stress. Prolactin (PRL) is an anti-anxiety factor that suppresses the hypothalamic–pituitary–adrenal axis. Here, we studied the roles of PRL, corticosterone (CORT), and their receptors in PS-induced anxiety-like behavior in dams and their offspring. We further investigated whether chewing during maternal stress could prevent PS-induced harmful consequences. Pregnant rats were randomly divided into PS, PS + chewing, and control groups. Anxiety-like behaviors of dams and their adolescent offspring were assessed using the open field test and elevated plus maze. Serum levels of PRL and CORT were measured by ELISA. Expression of mRNA and protein of PRLR and glucocorticoid receptor (GR) in the prefrontal cortex (PFC) were evaluated by qRT-PCR and western blotting, respectively. Compared to the control rats, dams and their female offspring, but not male offspring, in the PS group showed increased anxiety-like behaviors. The PS-affected rats had a lower serum PRL level and increased PRLR expression in the PFC. In contrast, these rats had a higher serum CORT level and decreased GR expression in the PFC. Chewing ameliorated anxiety-like behaviors and counteracted stress-induced changes in serum PRL and CORT, as well as the expression of their receptors in the PFC. Conclusion: PS-induced anxiety-like behavior is associated with changes in the serum levels of PRL and CORT and expression of their receptors in the PFC. Moreover, chewing blunts the hormonal and receptor changes and may serve as an effective stress-coping method for preventing PS-induced anxiety-like behavior." @default.
- W4313250943 created "2023-01-06" @default.
- W4313250943 creator A5000922152 @default.
- W4313250943 creator A5009728168 @default.
- W4313250943 creator A5015379959 @default.
- W4313250943 creator A5020264840 @default.
- W4313250943 creator A5024970317 @default.
- W4313250943 creator A5027475930 @default.
- W4313250943 creator A5028159410 @default.
- W4313250943 creator A5031742215 @default.
- W4313250943 creator A5036398299 @default.
- W4313250943 creator A5044622075 @default.
- W4313250943 creator A5064183739 @default.
- W4313250943 creator A5066060279 @default.
- W4313250943 creator A5067911129 @default.
- W4313250943 date "2023-01-01" @default.
- W4313250943 modified "2023-10-18" @default.
- W4313250943 title "Prolactin and glucocorticoid receptors in the prefrontal cortex are associated with anxiety‐like behavior in prenatally stressed adolescent offspring rats" @default.
- W4313250943 cites W1530266697 @default.
- W4313250943 cites W1964160578 @default.
- W4313250943 cites W1966933121 @default.
- W4313250943 cites W1969890501 @default.
- W4313250943 cites W1975064901 @default.
- W4313250943 cites W1982238228 @default.
- W4313250943 cites W1984913787 @default.
- W4313250943 cites W1999437903 @default.
- W4313250943 cites W2017844566 @default.
- W4313250943 cites W2030184709 @default.
- W4313250943 cites W2030601224 @default.
- W4313250943 cites W2032896285 @default.
- W4313250943 cites W2039713589 @default.
- W4313250943 cites W2040213955 @default.
- W4313250943 cites W2049163404 @default.
- W4313250943 cites W2071256705 @default.
- W4313250943 cites W2087239362 @default.
- W4313250943 cites W2113103296 @default.
- W4313250943 cites W2157406479 @default.
- W4313250943 cites W2159402783 @default.
- W4313250943 cites W2163659555 @default.
- W4313250943 cites W2413515606 @default.
- W4313250943 cites W2515218239 @default.
- W4313250943 cites W2594387995 @default.
- W4313250943 cites W2596099804 @default.
- W4313250943 cites W2596260339 @default.
- W4313250943 cites W2607341885 @default.
- W4313250943 cites W2625897054 @default.
- W4313250943 cites W2755206482 @default.
- W4313250943 cites W2755505605 @default.
- W4313250943 cites W2793048673 @default.
- W4313250943 cites W2804067401 @default.
- W4313250943 cites W2805753653 @default.
- W4313250943 cites W2809303956 @default.
- W4313250943 cites W2811455473 @default.
- W4313250943 cites W2963343281 @default.
- W4313250943 cites W2971949693 @default.
- W4313250943 cites W2973574953 @default.
- W4313250943 cites W3007947097 @default.
- W4313250943 cites W3008371933 @default.
- W4313250943 cites W3012167720 @default.
- W4313250943 cites W3016650759 @default.
- W4313250943 cites W3027350195 @default.
- W4313250943 cites W3116365240 @default.
- W4313250943 cites W3193334134 @default.
- W4313250943 cites W3196436311 @default.
- W4313250943 cites W4242324707 @default.
- W4313250943 cites W4248333072 @default.
- W4313250943 doi "https://doi.org/10.1111/jne.13231" @default.
- W4313250943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36683309" @default.
- W4313250943 hasPublicationYear "2023" @default.
- W4313250943 type Work @default.
- W4313250943 citedByCount "2" @default.
- W4313250943 countsByYear W43132509432023 @default.
- W4313250943 crossrefType "journal-article" @default.
- W4313250943 hasAuthorship W4313250943A5000922152 @default.
- W4313250943 hasAuthorship W4313250943A5009728168 @default.
- W4313250943 hasAuthorship W4313250943A5015379959 @default.
- W4313250943 hasAuthorship W4313250943A5020264840 @default.
- W4313250943 hasAuthorship W4313250943A5024970317 @default.
- W4313250943 hasAuthorship W4313250943A5027475930 @default.
- W4313250943 hasAuthorship W4313250943A5028159410 @default.
- W4313250943 hasAuthorship W4313250943A5031742215 @default.
- W4313250943 hasAuthorship W4313250943A5036398299 @default.
- W4313250943 hasAuthorship W4313250943A5044622075 @default.
- W4313250943 hasAuthorship W4313250943A5064183739 @default.
- W4313250943 hasAuthorship W4313250943A5066060279 @default.
- W4313250943 hasAuthorship W4313250943A5067911129 @default.
- W4313250943 hasConcept C112672928 @default.
- W4313250943 hasConcept C118552586 @default.
- W4313250943 hasConcept C126322002 @default.
- W4313250943 hasConcept C134018914 @default.
- W4313250943 hasConcept C15744967 @default.
- W4313250943 hasConcept C169900460 @default.
- W4313250943 hasConcept C170493617 @default.
- W4313250943 hasConcept C173586616 @default.
- W4313250943 hasConcept C2776443723 @default.
- W4313250943 hasConcept C2779064019 @default.
- W4313250943 hasConcept C2779085643 @default.
- W4313250943 hasConcept C2779234561 @default.
- W4313250943 hasConcept C2780352252 @default.
- W4313250943 hasConcept C2780841215 @default.