Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313251161> ?p ?o ?g. }
- W4313251161 abstract "Contractile epithelial tubes are found in various organs, such as lung airways and blood capillaries. Their ability to sense luminal pressure and respond with adequate contractility is essential for their physiology, and its mis-regulation results in diseases such as asthma and hypertension. Here, we describe a mechanoresponsive regulatory pathway downstream of tissue stretching that controls contraction of the C. elegans spermatheca, a tubular structure where fertilization occurs. Using live-imaging, we show that ovulation-induced stretching of spermathecal cells leads to recruitment of the RhoGEF RHGF-1 to stress fibers, which activates RHO-1 and myosin II in a positive feedback loop. Through deletion analysis, we identified the PDZ domain of RHGF-1 as responsible for F-actin binding, and genetic epistasis analysis with the RhoGAP spv-1 demonstrated that tension-dependent recruitment of RHGF-1 to F-actin is required for robust spermathecal contractility. Our study illustrates how mechanosensitive regulators of Rho GTPases provide epithelial tubes the ability to tune their contractility in response to internal pressure." @default.
- W4313251161 created "2023-01-06" @default.
- W4313251161 creator A5004919024 @default.
- W4313251161 creator A5006014570 @default.
- W4313251161 creator A5006110103 @default.
- W4313251161 creator A5009749498 @default.
- W4313251161 creator A5016776611 @default.
- W4313251161 creator A5021334926 @default.
- W4313251161 creator A5031255430 @default.
- W4313251161 creator A5031930821 @default.
- W4313251161 creator A5065149752 @default.
- W4313251161 creator A5066716119 @default.
- W4313251161 creator A5068994453 @default.
- W4313251161 date "2022-12-27" @default.
- W4313251161 modified "2023-10-10" @default.
- W4313251161 title "Tension-dependent RHGF-1 recruitment to stress fibers drives robust spermathecal tissue contraction" @default.
- W4313251161 cites W1538692246 @default.
- W4313251161 cites W1872263799 @default.
- W4313251161 cites W1894875272 @default.
- W4313251161 cites W1953931070 @default.
- W4313251161 cites W1966932918 @default.
- W4313251161 cites W1975545701 @default.
- W4313251161 cites W1984491329 @default.
- W4313251161 cites W1984944970 @default.
- W4313251161 cites W1985617800 @default.
- W4313251161 cites W1992482702 @default.
- W4313251161 cites W1993735775 @default.
- W4313251161 cites W2022002610 @default.
- W4313251161 cites W2030620933 @default.
- W4313251161 cites W2031439529 @default.
- W4313251161 cites W2033845112 @default.
- W4313251161 cites W2034924573 @default.
- W4313251161 cites W2038520092 @default.
- W4313251161 cites W2049863303 @default.
- W4313251161 cites W2050313698 @default.
- W4313251161 cites W2056811959 @default.
- W4313251161 cites W2061600983 @default.
- W4313251161 cites W2065115655 @default.
- W4313251161 cites W2067822993 @default.
- W4313251161 cites W2070439333 @default.
- W4313251161 cites W2071199281 @default.
- W4313251161 cites W2071657221 @default.
- W4313251161 cites W2102312968 @default.
- W4313251161 cites W2102554803 @default.
- W4313251161 cites W2111964892 @default.
- W4313251161 cites W2124860700 @default.
- W4313251161 cites W2131200617 @default.
- W4313251161 cites W2146473598 @default.
- W4313251161 cites W2150102283 @default.
- W4313251161 cites W2167279371 @default.
- W4313251161 cites W2169012342 @default.
- W4313251161 cites W2172020549 @default.
- W4313251161 cites W2300596338 @default.
- W4313251161 cites W2315069592 @default.
- W4313251161 cites W2414850204 @default.
- W4313251161 cites W2429042322 @default.
- W4313251161 cites W2543889215 @default.
- W4313251161 cites W2545003542 @default.
- W4313251161 cites W2593851974 @default.
- W4313251161 cites W2600184955 @default.
- W4313251161 cites W2622528018 @default.
- W4313251161 cites W2789976425 @default.
- W4313251161 cites W2793036692 @default.
- W4313251161 cites W2800455293 @default.
- W4313251161 cites W2899374476 @default.
- W4313251161 cites W2948403375 @default.
- W4313251161 cites W2950325533 @default.
- W4313251161 cites W2951746784 @default.
- W4313251161 cites W2998312375 @default.
- W4313251161 cites W3007396121 @default.
- W4313251161 cites W3012860965 @default.
- W4313251161 cites W3022607448 @default.
- W4313251161 cites W3040217928 @default.
- W4313251161 cites W3048616880 @default.
- W4313251161 cites W3088408356 @default.
- W4313251161 cites W3088772533 @default.
- W4313251161 cites W3089477642 @default.
- W4313251161 cites W3092350202 @default.
- W4313251161 cites W3093036558 @default.
- W4313251161 cites W3108837341 @default.
- W4313251161 doi "https://doi.org/10.1083/jcb.202203105" @default.
- W4313251161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36574264" @default.
- W4313251161 hasPublicationYear "2022" @default.
- W4313251161 type Work @default.
- W4313251161 citedByCount "0" @default.
- W4313251161 crossrefType "journal-article" @default.
- W4313251161 hasAuthorship W4313251161A5004919024 @default.
- W4313251161 hasAuthorship W4313251161A5006014570 @default.
- W4313251161 hasAuthorship W4313251161A5006110103 @default.
- W4313251161 hasAuthorship W4313251161A5009749498 @default.
- W4313251161 hasAuthorship W4313251161A5016776611 @default.
- W4313251161 hasAuthorship W4313251161A5021334926 @default.
- W4313251161 hasAuthorship W4313251161A5031255430 @default.
- W4313251161 hasAuthorship W4313251161A5031930821 @default.
- W4313251161 hasAuthorship W4313251161A5065149752 @default.
- W4313251161 hasAuthorship W4313251161A5066716119 @default.
- W4313251161 hasAuthorship W4313251161A5068994453 @default.
- W4313251161 hasBestOaLocation W43132511611 @default.
- W4313251161 hasConcept C105702510 @default.
- W4313251161 hasConcept C125705527 @default.