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• W4313251221 abstract "Pineal region tumors constitute a rare group of neoplasms. Primary neuronal tumor that intrinsically arise from the pineal gland are referred to as pineal parenchymal tumors (PPTs). Their neuropathological spectrum is divided into well-differentiated “pineocytoma” (World Health Organization [WHO] grade I), pineal parenchymal tumors of intermediate differentiation and papillary tumor of pineal region (WHO grades II and III), and poorly differentiated “pinealoblastoma” (WHO grade IV).[1] Pleomorphic cytological variant of pineocytoma has been rarely reported in the medical literature mainly in form of case reports. A 45-year-old man with a recent history of right-sided stroke presented to the neurosurgery department with complaint of headache for last 1 month. Multislice computed tomography (CT) imaging revealed an ill-defined hyperdense space-occupying lesion with internal calcification. The tumor was located in the region of pineal gland with extension into the adjacent lateral ventricle and resultant mild obstructive hydrocephalus. MRI scan revealed a hyperdense nodular lesion measuring 24 × 18 mm with scant peritumoral edema ([Fig. 1A] and [1B]). Following placement of a ventriculo peritoneal shunt, stereotactic biopsy was performed and submitted to the pathology department. Histopathological examination revealed a pineal parenchymal neoplasm with varied morphology. In some areas, the tumor cells were small and uniform resembling pinealocytes, and arranged in sheets and at places forming pineocytomatous rosettes with abundant delicate tumor cell processes. ([Fig. 2A]) Their nuclei were round to oval with inconspicuous nucleoli and finely dispersed chromatin. However, in other areas, the tumor was less cellular with the presence of several multinucleated giant cells and bizarre nuclei exhibiting marked nuclear pleomorphism with hyperchromasia ([Fig. 2B]). Interstitial stroma demonstrated presence of hyaline vessels and reticulin fibrils. Mitotic figures were lacking (< 1 mitosis/10 High power field (HPF)) in the tumor. No ganglionic differentiation was observed in the present case. Immunohistochemical examination revealed neuronal tumor immunophenotype with diffuse positivity for non-specific enolase, synaptophysin, and focal positivity for S-100. The tumor cells were negative for glial fibrillary acidic protein (GFAP), placental alkaline phosphatase (PLAP), Human Chorionic Gonadotropin (HCG), and pan–cytokeratin. Ki-67 proliferation index was less than 1%. The expression of GFAP was observed only in the resident astrocytes . A striking feature observed in the present case was the presence of numerous mast cells that were concentrically arranged around larger blood vessels. Toluidine blue stain and CD117 highlighted the presence of mast cells ([Fig. 3A]–[3C])." @default.
• W4313251221 created "2023-01-06" @default.
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• W4313251221 date "2022-12-27" @default.
• W4313251221 modified "2023-10-18" @default.
• W4313251221 title "Mast Cell-Rich Pleomorphic Pineocytoma: A Rare Entity" @default.
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• W4313251221 doi "https://doi.org/10.1055/s-0042-1756489" @default.
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