Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313251421> ?p ?o ?g. }
- W4313251421 endingPage "270" @default.
- W4313251421 startingPage "263" @default.
- W4313251421 abstract "Magnetic resonance imaging (MRI) is a widely used non-invasive medical imaging tool. Nanoparticle-based MRI contrast agents have received considerable attention due to their high loading capability for magnetic species, enhanced accumulation in lesions, and versatile surface functionalization. Anisotropic nanoparticles such as nanofibers can exhibit significant advantages over their well-explored spherical counterparts in terms of their pharmacokinetic and biodistribution profiles. Herein, we report the retrosynthetic design, synthesis, and characterization of uniform and length-tunable paramagnetic core-shell nanofibers for MRI through the use of the seeded-growth “living” crystallization-driven self-assembly (CDSA) approach. Triblock copolymer (TriBCP) precursors with a crystallizable polycarbonate core-forming segment, a nitroxide-bearing central region, and a hydrophilic poly(ethylene glycol) (PEG) terminal corona-forming segment were prepared via sequential living organocatalytic ring-opening polymerization (ROP). Low dispersity nanofibers of length ca. 80 nm relevant for biomedical applications were prepared for detailed studies by living CDSA and these possessed an average number of nitroxides per nanofiber of >8000. Subsequent evaluation of the water-proton relaxivities demonstrated that tuning the hydrophilicity of the central segment in the TriBCP allowed access to nanofibers with impressive performance compared to most existing polymer-based nitroxide-based contrast agents. As a result of their 1D morphology, the synthetic nanofibers therefore represent promising organic radical contrast agents (ORCAs) for MRI applications." @default.
- W4313251421 created "2023-01-06" @default.
- W4313251421 creator A5014708668 @default.
- W4313251421 creator A5016835165 @default.
- W4313251421 creator A5022900068 @default.
- W4313251421 creator A5034180252 @default.
- W4313251421 creator A5065378680 @default.
- W4313251421 creator A5073112631 @default.
- W4313251421 creator A5076582889 @default.
- W4313251421 date "2022-12-27" @default.
- W4313251421 modified "2023-09-27" @default.
- W4313251421 title "Uniform and Length-Tunable, Paramagnetic Self-Assembled Nitroxide-Based Nanofibers for Magnetic Resonance Imaging" @default.
- W4313251421 cites W1508422361 @default.
- W4313251421 cites W1742887464 @default.
- W4313251421 cites W1976915466 @default.
- W4313251421 cites W1977096237 @default.
- W4313251421 cites W1982933823 @default.
- W4313251421 cites W1990232537 @default.
- W4313251421 cites W1995976462 @default.
- W4313251421 cites W2003265015 @default.
- W4313251421 cites W2011050295 @default.
- W4313251421 cites W2028904044 @default.
- W4313251421 cites W2051911214 @default.
- W4313251421 cites W2059223510 @default.
- W4313251421 cites W2061283891 @default.
- W4313251421 cites W2064349006 @default.
- W4313251421 cites W2080492017 @default.
- W4313251421 cites W2084309113 @default.
- W4313251421 cites W2095849709 @default.
- W4313251421 cites W2104558356 @default.
- W4313251421 cites W2143463421 @default.
- W4313251421 cites W2165215612 @default.
- W4313251421 cites W2296794835 @default.
- W4313251421 cites W2307321352 @default.
- W4313251421 cites W2324726120 @default.
- W4313251421 cites W2326295124 @default.
- W4313251421 cites W2417491354 @default.
- W4313251421 cites W2477103182 @default.
- W4313251421 cites W2516726340 @default.
- W4313251421 cites W2587667558 @default.
- W4313251421 cites W2597613531 @default.
- W4313251421 cites W2608601148 @default.
- W4313251421 cites W2621982759 @default.
- W4313251421 cites W2668780319 @default.
- W4313251421 cites W2734421642 @default.
- W4313251421 cites W2752103530 @default.
- W4313251421 cites W2752133697 @default.
- W4313251421 cites W2765748477 @default.
- W4313251421 cites W2802823716 @default.
- W4313251421 cites W2803853571 @default.
- W4313251421 cites W2811501377 @default.
- W4313251421 cites W2896682297 @default.
- W4313251421 cites W2898877847 @default.
- W4313251421 cites W2899386875 @default.
- W4313251421 cites W2934543521 @default.
- W4313251421 cites W2954526938 @default.
- W4313251421 cites W2964997728 @default.
- W4313251421 cites W2994711810 @default.
- W4313251421 cites W2996488368 @default.
- W4313251421 cites W3004803847 @default.
- W4313251421 cites W3011767547 @default.
- W4313251421 cites W3033166573 @default.
- W4313251421 cites W3042069402 @default.
- W4313251421 cites W3107369504 @default.
- W4313251421 cites W3115046480 @default.
- W4313251421 cites W3122352939 @default.
- W4313251421 cites W3130093081 @default.
- W4313251421 cites W3132055573 @default.
- W4313251421 cites W3154865223 @default.
- W4313251421 cites W3169388681 @default.
- W4313251421 cites W3172821110 @default.
- W4313251421 cites W3176315105 @default.
- W4313251421 cites W3185073085 @default.
- W4313251421 cites W3196784472 @default.
- W4313251421 cites W4224224499 @default.
- W4313251421 cites W4225620067 @default.
- W4313251421 cites W4285132214 @default.
- W4313251421 doi "https://doi.org/10.1021/acs.macromol.2c02227" @default.
- W4313251421 hasPublicationYear "2022" @default.
- W4313251421 type Work @default.
- W4313251421 citedByCount "2" @default.
- W4313251421 countsByYear W43132514212023 @default.
- W4313251421 crossrefType "journal-article" @default.
- W4313251421 hasAuthorship W4313251421A5014708668 @default.
- W4313251421 hasAuthorship W4313251421A5016835165 @default.
- W4313251421 hasAuthorship W4313251421A5022900068 @default.
- W4313251421 hasAuthorship W4313251421A5034180252 @default.
- W4313251421 hasAuthorship W4313251421A5065378680 @default.
- W4313251421 hasAuthorship W4313251421A5073112631 @default.
- W4313251421 hasAuthorship W4313251421A5076582889 @default.
- W4313251421 hasConcept C111998727 @default.
- W4313251421 hasConcept C11432220 @default.
- W4313251421 hasConcept C127413603 @default.
- W4313251421 hasConcept C155672457 @default.
- W4313251421 hasConcept C15920480 @default.
- W4313251421 hasConcept C159985019 @default.
- W4313251421 hasConcept C169912494 @default.
- W4313251421 hasConcept C171250308 @default.