Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313251447> ?p ?o ?g. }
- W4313251447 endingPage "1008" @default.
- W4313251447 startingPage "995" @default.
- W4313251447 abstract "Background Although pre-clinical experiments associate cannabinoids with reduced depressive symptoms, there is a paucity of clinical evidence. This study aimed to analyze the health-related quality of life changes and safety outcomes in patients prescribed cannabis-based medicinal products (CBMPs) for depression.Methods An uncontrolled case series of the UK Medical Cannabis Registry was analyzed. Primary outcomes were changes from baseline in the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Sleep Quality Scale (SQS), and EQ-5D-5L at 1, 3, and 6 months. Secondary outcomes included adverse events incidence.Results 129 patients were identified for inclusion. Median PHQ-9 at baseline was 16.0 (IQR: 9.0-21.0). There were reductions in PHQ-9 at 1-month (median: 8.0; IQR: 4.0-14.0; p<0.001), 3-months (7.0; 2.3-12.8; p<0.001), and 6-months (7.0; 2.0-9.5; p<0.001). Improvements were also observed in GAD-7, SQS, and EQ-5D-5L Index Value at 1, 3, and 6 months (p<0.050). 153 (118.6%) adverse events were recorded by 14.0% (n=18) of participants, 87% (n=133) of which were mild or moderate.Conclusion CBMP treatment was associated with reductions in depression severity at 1, 3, and 6 months. Limitations of the study design mean that a causal relationship cannot be proven. This analysis provides insights for further study within clinical trial settings." @default.
- W4313251447 created "2023-01-06" @default.
- W4313251447 creator A5004616583 @default.
- W4313251447 creator A5007569216 @default.
- W4313251447 creator A5008454203 @default.
- W4313251447 creator A5008923340 @default.
- W4313251447 creator A5036473530 @default.
- W4313251447 creator A5042444567 @default.
- W4313251447 creator A5053998431 @default.
- W4313251447 creator A5055833122 @default.
- W4313251447 creator A5057393149 @default.
- W4313251447 creator A5060429192 @default.
- W4313251447 creator A5070462206 @default.
- W4313251447 creator A5087044435 @default.
- W4313251447 date "2022-11-02" @default.
- W4313251447 modified "2023-10-18" @default.
- W4313251447 title "Assessment of clinical outcomes of medicinal cannabis therapy for depression: analysis from the UK Medical Cannabis Registry" @default.
- W4313251447 cites W1409549508 @default.
- W4313251447 cites W1552862994 @default.
- W4313251447 cites W1593785499 @default.
- W4313251447 cites W16698172 @default.
- W4313251447 cites W1823623062 @default.
- W4313251447 cites W1842042263 @default.
- W4313251447 cites W1886084954 @default.
- W4313251447 cites W1940834207 @default.
- W4313251447 cites W1945751328 @default.
- W4313251447 cites W1986956603 @default.
- W4313251447 cites W1987613482 @default.
- W4313251447 cites W1990166011 @default.
- W4313251447 cites W2000445173 @default.
- W4313251447 cites W2004762037 @default.
- W4313251447 cites W2013564592 @default.
- W4313251447 cites W2036272035 @default.
- W4313251447 cites W2036547523 @default.
- W4313251447 cites W2037457456 @default.
- W4313251447 cites W2043705607 @default.
- W4313251447 cites W2044573242 @default.
- W4313251447 cites W2055974480 @default.
- W4313251447 cites W2056588555 @default.
- W4313251447 cites W2072316081 @default.
- W4313251447 cites W2074250881 @default.
- W4313251447 cites W2097387720 @default.
- W4313251447 cites W2097747770 @default.
- W4313251447 cites W2100987960 @default.
- W4313251447 cites W2103654989 @default.
- W4313251447 cites W2110203263 @default.
- W4313251447 cites W2110690684 @default.
- W4313251447 cites W2111202432 @default.
- W4313251447 cites W2120142285 @default.
- W4313251447 cites W2120564644 @default.
- W4313251447 cites W2123906642 @default.
- W4313251447 cites W2125327134 @default.
- W4313251447 cites W2126292939 @default.
- W4313251447 cites W2127438675 @default.
- W4313251447 cites W2128552597 @default.
- W4313251447 cites W2132322340 @default.
- W4313251447 cites W2133512209 @default.
- W4313251447 cites W2139339819 @default.
- W4313251447 cites W2140180096 @default.
- W4313251447 cites W2157194959 @default.
- W4313251447 cites W2157903425 @default.
- W4313251447 cites W2166281097 @default.
- W4313251447 cites W2346108119 @default.
- W4313251447 cites W2516266560 @default.
- W4313251447 cites W2529861061 @default.
- W4313251447 cites W2589033717 @default.
- W4313251447 cites W2609632515 @default.
- W4313251447 cites W2739905229 @default.
- W4313251447 cites W2788337440 @default.
- W4313251447 cites W2789276845 @default.
- W4313251447 cites W2884234708 @default.
- W4313251447 cites W2900723373 @default.
- W4313251447 cites W2940792917 @default.
- W4313251447 cites W2961812469 @default.
- W4313251447 cites W2974788990 @default.
- W4313251447 cites W2981824949 @default.
- W4313251447 cites W2988978265 @default.
- W4313251447 cites W3004703759 @default.
- W4313251447 cites W3006654055 @default.
- W4313251447 cites W3022971354 @default.
- W4313251447 cites W3035266011 @default.
- W4313251447 cites W3037386379 @default.
- W4313251447 cites W3080549645 @default.
- W4313251447 cites W3096255650 @default.
- W4313251447 cites W3115563276 @default.
- W4313251447 cites W3131861699 @default.
- W4313251447 cites W3162362404 @default.
- W4313251447 cites W3171328702 @default.
- W4313251447 cites W3175468061 @default.
- W4313251447 cites W3185217188 @default.
- W4313251447 cites W3194979595 @default.
- W4313251447 cites W3199895344 @default.
- W4313251447 cites W3202140271 @default.
- W4313251447 cites W3215400878 @default.
- W4313251447 cites W4207055665 @default.
- W4313251447 cites W4211224559 @default.
- W4313251447 cites W4224125032 @default.
- W4313251447 doi "https://doi.org/10.1080/14737175.2022.2161894" @default.