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• W4313251641 abstract "Predator detection is key to animal's survival. Superior colliculus (SC) orchestrates the animal's innate defensive responses to visually detected threats, but how threat information is transmitted from the retina to SC is unknown. We discovered that narrow-field neurons in SC were key in this pathway. Using in vivo calcium imaging and optogenetics-assisted interrogation of circuit and synaptic connections, we found that the visual responses of narrow-field neurons were correlated with the animal's defensive behaviors toward visual stimuli. Activation of these neurons triggered defensive behaviors, and ablation of them impaired the animals' defensive responses to looming stimuli. They receive monosynaptic inputs from looming-sensitive OFF-transient alpha retinal ganglion cells, and the synaptic transmission has a unique band-pass feature that helps to shape their stimulus selectivity. Our results describe a cell-type specific retinotectal connection for visual threat detection, and a coding mechanism based on synaptic filtering." @default.
• W4313251641 created "2023-01-06" @default.
• W4313251641 creator A5019190057 @default.
• W4313251641 creator A5022172078 @default.
• W4313251641 creator A5061969960 @default.
• W4313251641 date "2022-12-27" @default.
• W4313251641 modified "2023-09-30" @default.
• W4313251641 title "A synaptic filtering mechanism in visual threat identification in mouse" @default.
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• W4313251641 doi "https://doi.org/10.1073/pnas.2212786120" @default.
• W4313251641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36574675" @default.
• W4313251641 hasPublicationYear "2022" @default.
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