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- W4313251844 abstract "Abstract Construction of C-N bond continues to be one part of the most significant goals in organic chemistry because of the universal applications of amines in pharmaceuticals, materials and agrochemicals. However, E2 elimination through classic S N 2 substitution of alkyl halides lead to generation of alkenes as major side-products. Thus, formation of a challenging C(sp 3 )-N bond especially on tertiary carbon center remains highly desirable. Herein, we present a practical alternative to prepare primary, secondary and tertiary alkyl amines with high efficiency between alkyl iodides and easily accessible diazonium salts. This robust transformation only employs Cs 2 CO 3 promoting halogen-atom transfer (XAT) process under transition-metal-free reaction conditions, thus providing a rapid method to assemble diverse C(sp 3 )-N bonds. Moreover, diazonium salts served as alkyl radical initiator and amination reagent in the reaction. Mechanism studies suggest this reaction undergo through halogen-atom transfer process to generate active alkyl radical which couples with diazonium cations to furnish final products." @default.
- W4313251844 created "2023-01-06" @default.
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- W4313251844 date "2022-12-27" @default.
- W4313251844 modified "2023-10-12" @default.
- W4313251844 title "Transition-metal free C–N bond formation from alkyl iodides and diazonium salts via halogen-atom transfer" @default.
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- W4313251844 doi "https://doi.org/10.1038/s41467-022-35613-7" @default.
- W4313251844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36575172" @default.
- W4313251844 hasPublicationYear "2022" @default.
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