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- W4313252002 abstract "Unraveling cell-cell interaction is fundamental to understanding many biological processes. To date, genetic tools for labeling neighboring cells in mammals are not available. Here, we developed a labeling strategy based on the Cre-induced intercellular labeling protein (CILP). Cre-expressing donor cells release a lipid-soluble and membrane-permeable fluorescent protein that is then taken up by recipient cells, enabling fluorescent labeling of neighboring cells. Using CILP, we specifically labeled endothelial cells surrounding a special population of hepatocytes in adult mice and revealed their distinct gene signatures. Our results highlight the potential of CILP as a platform to reveal cell-cell interactions and communications in vivo." @default.
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- W4313252002 date "2022-12-27" @default.
- W4313252002 modified "2023-10-14" @default.
- W4313252002 title "Genetic dissection of intercellular interactions in vivo by membrane-permeable protein" @default.
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- W4313252002 doi "https://doi.org/10.1073/pnas.2120582120" @default.
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