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- W4313252321 endingPage "154632" @default.
- W4313252321 startingPage "154632" @default.
- W4313252321 abstract "Tanshinone I (Tan I) is known as one of the important active components in Salvia miltiorrhiza. In recent years, Tan I has received a substantial amount of attention from the research community for various studies being updated and has been shown to possess favorable activities including anti-oxidative stress, regulation of cell autophagy or apoptosis, inhibition of inflammation, etc. PURPOSE: To summarize the investigation progress on the anti-disease efficacy and effect mechanism of Tan I in recent years, and provide perspectives for future study on the active ingredient.Web of Science and PubMed databases were used to search for articles related to Tanshinone I published from 2010 to 2022. Proteins or genes and signaling pathways referring to Tan I against diseases were summarized and classified along with its different therapeutic actions. Protein-protein interaction (PPI) analysis was then performed, followed by molecular docking between proteins with high node degree and Tan I, as well as bioinformactic analysis including GO, KEGG and DO enrichment analysis with the collected proteins or genes.Tan I shows multiple therapeutic effects, including protection of the cardiovascular system, anti-cancer, anti-inflammatory, anti-neurodegenerative diseases, etc. The targets (proteins or genes) affected by Tan I against diseases involve Bcl-2, Bid, ITGA2, PPAT, AURKA, VEGF, PI3K, AKT, PRK, JNK, MMP9, ABCG2, CASP3, Cleaved-caspase-3, AMPKα, PARP, etc., and the regulatory pathways refer to Akt/Nrf2, SAPK/JNK, PI3K/Akt/mTOR, JAK/STAT3, ATF-2/ERK, etc. What's more, AKT1, CASP3, and STAT3 were predicted as the key action targets for Tan I by PPI analysis combined with molecular docking, and the potential therapeutic effects mechanisms against diseases were also further predicted by bioinformatics analyses based on the reported targets, providing new insights into the future investigation and helping to facilitate the drug development of Tan I." @default.
- W4313252321 created "2023-01-06" @default.
- W4313252321 creator A5002876333 @default.
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- W4313252321 creator A5032180201 @default.
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- W4313252321 creator A5071186046 @default.
- W4313252321 creator A5073524555 @default.
- W4313252321 creator A5074200075 @default.
- W4313252321 creator A5077604881 @default.
- W4313252321 date "2023-02-01" @default.
- W4313252321 modified "2023-10-18" @default.
- W4313252321 title "Tanshinone I: Pharmacological activities, molecular mechanisms against diseases and future perspectives" @default.
- W4313252321 cites W1774426949 @default.
- W4313252321 cites W1821806054 @default.
- W4313252321 cites W1912417670 @default.
- W4313252321 cites W1915538437 @default.
- W4313252321 cites W1967332266 @default.
- W4313252321 cites W1972713500 @default.
- W4313252321 cites W1981606437 @default.
- W4313252321 cites W1982160027 @default.
- W4313252321 cites W1984695893 @default.
- W4313252321 cites W1985474993 @default.
- W4313252321 cites W1989867453 @default.
- W4313252321 cites W1990904704 @default.
- W4313252321 cites W1992224451 @default.
- W4313252321 cites W2011428346 @default.
- W4313252321 cites W2011827522 @default.
- W4313252321 cites W2019024302 @default.
- W4313252321 cites W2022391443 @default.
- W4313252321 cites W2023973572 @default.
- W4313252321 cites W2025830373 @default.
- W4313252321 cites W2030365903 @default.
- W4313252321 cites W2035618305 @default.
- W4313252321 cites W2043262930 @default.
- W4313252321 cites W2045261772 @default.
- W4313252321 cites W2048218352 @default.
- W4313252321 cites W2054648838 @default.
- W4313252321 cites W2054988846 @default.
- W4313252321 cites W2060198845 @default.
- W4313252321 cites W2098462520 @default.
- W4313252321 cites W2102015113 @default.
- W4313252321 cites W2113528784 @default.
- W4313252321 cites W2130534254 @default.
- W4313252321 cites W2139619092 @default.
- W4313252321 cites W2154066769 @default.
- W4313252321 cites W2187107220 @default.
- W4313252321 cites W2261085470 @default.
- W4313252321 cites W2309510424 @default.
- W4313252321 cites W2323216618 @default.
- W4313252321 cites W2334483166 @default.
- W4313252321 cites W2337086469 @default.
- W4313252321 cites W2411981799 @default.
- W4313252321 cites W2588891882 @default.
- W4313252321 cites W2728183201 @default.
- W4313252321 cites W2740047490 @default.
- W4313252321 cites W2761122503 @default.
- W4313252321 cites W2793433885 @default.
- W4313252321 cites W2806174677 @default.
- W4313252321 cites W2885156382 @default.
- W4313252321 cites W2889646458 @default.
- W4313252321 cites W2890279221 @default.
- W4313252321 cites W2903491648 @default.
- W4313252321 cites W2905875342 @default.
- W4313252321 cites W2911831872 @default.
- W4313252321 cites W2913315929 @default.
- W4313252321 cites W2915895704 @default.
- W4313252321 cites W2921031362 @default.
- W4313252321 cites W2953014442 @default.
- W4313252321 cites W2954366821 @default.
- W4313252321 cites W2960755589 @default.
- W4313252321 cites W2979337403 @default.
- W4313252321 cites W2989281995 @default.
- W4313252321 cites W2993289461 @default.
- W4313252321 cites W2995859967 @default.
- W4313252321 cites W2998919774 @default.
- W4313252321 cites W3004419980 @default.
- W4313252321 cites W3004510868 @default.
- W4313252321 cites W3011644616 @default.
- W4313252321 cites W3012646333 @default.
- W4313252321 cites W3018715435 @default.
- W4313252321 cites W3037488290 @default.
- W4313252321 cites W3094039673 @default.
- W4313252321 cites W3117886022 @default.
- W4313252321 cites W3118615836 @default.
- W4313252321 cites W3127748047 @default.
- W4313252321 cites W3130224122 @default.
- W4313252321 cites W3149318599 @default.
- W4313252321 cites W3160887851 @default.
- W4313252321 cites W3161870164 @default.
- W4313252321 cites W3164785004 @default.
- W4313252321 cites W3179294507 @default.
- W4313252321 cites W3188869677 @default.
- W4313252321 cites W3189906493 @default.
- W4313252321 cites W3199945255 @default.
- W4313252321 cites W3213994487 @default.
- W4313252321 cites W4206942347 @default.
- W4313252321 cites W4280571878 @default.