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• W4313252466 endingPage "119824" @default.
• W4313252466 startingPage "119824" @default.
• W4313252466 abstract "In this study, we optimized the variable flip angle (VFA) acquisition scheme using numerical simulations to shorten the acquisition time of multicompartment relaxometry for myelin water imaging (MCR-MWI) to a clinically practical range in the absence of advanced image reconstruction methods. As the primary objective of this study, the test-retest repeatability of myelin water fraction (MWF) measurements of MCR-MWI is evaluated on three gradient echo (GRE) sequence settings using the optimized VFA schemes with different echo times and repetition times, emulating various scanner setups. The cross-protocol reproducibility of MCR-MWI and MCR with diffusion-informed myelin water imaging (MCR-DIMWI) is also examined. As a secondary objective, we explore the bundle-specific profiles of various microstructural parameters from MCR-(DI)MWI and their cross-correlations to determine if these parameters possess supplementary microstructure information beyond myelin concentration. Numerical simulations indicate that MCR-MWI can be performed with a minimum of three flip angles covering a wide range of T1 weightings without adding significant bias. This is supported by the results of an in vivo experiment, allowing whole-brain 1.5 mm isotropic MWF maps to be acquired in 9 min, reducing the total scan time to 40% of the original implementation without significant quality degradation. Good test-retest repeatability is observed for MCR-MWI for all three GRE protocols. While good correlations can also be found in MWF across protocols, systematic differences are observed. Bundle-specific MWF analysis reveals that certain white matter bundles are similar in all participants. We also found that microstructure relaxation parameters have low linear correlations with MWF. MCR-MWI is a reproducible measure of myelin. However, attention should be paid to the protocol related MWF differences when comparing different studies, as the MWF bias up to 0.5% can be observed across the protocols examined in this work." @default.
• W4313252466 created "2023-01-06" @default.
• W4313252466 creator A5016183041 @default.
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• W4313252466 date "2023-02-01" @default.
• W4313252466 modified "2023-10-14" @default.
• W4313252466 title "On the performance of multi-compartment relaxometry for myelin water imaging (MCR-MWI) – test-retest repeatability and inter-protocol reproducibility" @default.
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• W4313252466 doi "https://doi.org/10.1016/j.neuroimage.2022.119824" @default.
• W4313252466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36539169" @default.
• W4313252466 hasPublicationYear "2023" @default.
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