FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313252578> ?p ?o ?g. }

• W4313252578 endingPage "108311" @default.
• W4313252578 startingPage "108311" @default.
• W4313252578 abstract "As one of the most important and frequently used molecular imaging techniques in the clinic, positron emission tomography (PET) features high sensitivity and specificity, which generally involves the use of PET contrast agents. Despite the exceptional promise, the availability of novel PET agents could limit its application and there is a clear need to develop new PET agents to improve our understanding of targets of interest and increase the diagnostic specificity.Based on the fact that amino acid transport and protein anabolism are increased in tumor tissues, a series of 18F-labeled amino acid analog was labeled with 18F by using [18F]fluoro-4-(vinylsulfonyl)benzene as the radionuclide linker. The obtained probes were subjected to in vitro and in vivo evaluation, including stability, cell line transport channel specificity, PET/CT imaging on tumor and inflammation bearing mice, and biodistribution.Our data shows that [18F]2a had moderate decay corrected labeling yield (>42 %) and high radiochemical purity (>99 %). When tested in vivo, the uptake of [18F]2a was 1.5 ± 0.2%ID/g in NCI-H1975 tumors and 1.1 ± 0.2%ID/g in inflammatory tissues. In contrast, the values for [18F]FDG were 5.7 ± 0.2%ID/g and 4.8 ± 0.1%ID/g, respectively. The inflammatory lesion-to-muscle contrast is 2.4 for [18F]2a, which is 3.0 for [18F]FDG.Clearly, [18F]2a hold the great potential for cancer imaging. Its application in distinguishing tumor from inflammatory lesion would still need to be investigated further." @default.
• W4313252578 created "2023-01-06" @default.
• W4313252578 creator A5006568183 @default.
• W4313252578 creator A5012207340 @default.
• W4313252578 creator A5012278873 @default.
• W4313252578 creator A5013703711 @default.
• W4313252578 creator A5030967805 @default.
• W4313252578 creator A5036925342 @default.
• W4313252578 creator A5045554941 @default.
• W4313252578 creator A5061482746 @default.
• W4313252578 creator A5073401057 @default.
• W4313252578 creator A5075879194 @default.
• W4313252578 creator A5085918263 @default.
• W4313252578 date "2023-01-01" @default.
• W4313252578 modified "2023-09-28" @default.
• W4313252578 title "Evaluation of sulfone-labeled amino acid derivatives as potential PET agents for cancer imaging" @default.
• W4313252578 cites W2030440323 @default.
• W4313252578 cites W2089755573 @default.
• W4313252578 cites W2095452241 @default.
• W4313252578 cites W2101801854 @default.
• W4313252578 cites W2106213970 @default.
• W4313252578 cites W2110184913 @default.
• W4313252578 cites W2154736475 @default.
• W4313252578 cites W2238016186 @default.
• W4313252578 cites W2286284757 @default.
• W4313252578 cites W2343615323 @default.
• W4313252578 cites W2543912773 @default.
• W4313252578 cites W2568298032 @default.
• W4313252578 cites W2782911334 @default.
• W4313252578 cites W2908941863 @default.
• W4313252578 cites W2912789083 @default.
• W4313252578 cites W2953988494 @default.
• W4313252578 cites W2955915418 @default.
• W4313252578 cites W2956165827 @default.
• W4313252578 cites W2991088630 @default.
• W4313252578 cites W3012033351 @default.
• W4313252578 cites W3082766172 @default.
• W4313252578 cites W3093945527 @default.
• W4313252578 cites W3101588999 @default.
• W4313252578 cites W3117336707 @default.
• W4313252578 cites W3120807331 @default.
• W4313252578 cites W3159035039 @default.
• W4313252578 cites W3176820481 @default.
• W4313252578 cites W3181673841 @default.
• W4313252578 cites W3181835375 @default.
• W4313252578 cites W3213085405 @default.
• W4313252578 cites W3215336940 @default.
• W4313252578 cites W4213457002 @default.
• W4313252578 doi "https://doi.org/10.1016/j.nucmedbio.2022.108311" @default.
• W4313252578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36580767" @default.
• W4313252578 hasPublicationYear "2023" @default.
• W4313252578 type Work @default.
• W4313252578 citedByCount "0" @default.
• W4313252578 crossrefType "journal-article" @default.
• W4313252578 hasAuthorship W4313252578A5006568183 @default.
• W4313252578 hasAuthorship W4313252578A5012207340 @default.
• W4313252578 hasAuthorship W4313252578A5012278873 @default.
• W4313252578 hasAuthorship W4313252578A5013703711 @default.
• W4313252578 hasAuthorship W4313252578A5030967805 @default.
• W4313252578 hasAuthorship W4313252578A5036925342 @default.
• W4313252578 hasAuthorship W4313252578A5045554941 @default.
• W4313252578 hasAuthorship W4313252578A5061482746 @default.
• W4313252578 hasAuthorship W4313252578A5073401057 @default.
• W4313252578 hasAuthorship W4313252578A5075879194 @default.
• W4313252578 hasAuthorship W4313252578A5085918263 @default.
• W4313252578 hasBestOaLocation W43132525781 @default.
• W4313252578 hasConcept C104317684 @default.
• W4313252578 hasConcept C121608353 @default.
• W4313252578 hasConcept C126322002 @default.
• W4313252578 hasConcept C136339569 @default.
• W4313252578 hasConcept C149011108 @default.
• W4313252578 hasConcept C150903083 @default.
• W4313252578 hasConcept C185592680 @default.
• W4313252578 hasConcept C202751555 @default.
• W4313252578 hasConcept C207001950 @default.
• W4313252578 hasConcept C2775842073 @default.
• W4313252578 hasConcept C2777807558 @default.
• W4313252578 hasConcept C2779931791 @default.
• W4313252578 hasConcept C2781313199 @default.
• W4313252578 hasConcept C2989005 @default.
• W4313252578 hasConcept C502942594 @default.
• W4313252578 hasConcept C515207424 @default.
• W4313252578 hasConcept C55493867 @default.
• W4313252578 hasConcept C71924100 @default.
• W4313252578 hasConcept C86803240 @default.
• W4313252578 hasConceptScore W4313252578C104317684 @default.
• W4313252578 hasConceptScore W4313252578C121608353 @default.
• W4313252578 hasConceptScore W4313252578C126322002 @default.
• W4313252578 hasConceptScore W4313252578C136339569 @default.
• W4313252578 hasConceptScore W4313252578C149011108 @default.
• W4313252578 hasConceptScore W4313252578C150903083 @default.
• W4313252578 hasConceptScore W4313252578C185592680 @default.
• W4313252578 hasConceptScore W4313252578C202751555 @default.
• W4313252578 hasConceptScore W4313252578C207001950 @default.
• W4313252578 hasConceptScore W4313252578C2775842073 @default.
• W4313252578 hasConceptScore W4313252578C2777807558 @default.
• W4313252578 hasConceptScore W4313252578C2779931791 @default.
• W4313252578 hasConceptScore W4313252578C2781313199 @default.

• next