FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313252589> ?p ?o ?g. }

• W4313252589 endingPage "13" @default.
• W4313252589 startingPage "1" @default.
• W4313252589 abstract "Lespedeza bicolor (LB) is known to have antidiabetic activities; however, the underlying molecular mechanisms of LB in hyperglycemia-induced skeletal muscle damage is unclear. Inflammation and oxidative stress caused by type 2 diabetes mellitus (T2DM) not only contributes to insulin resistance, but also promotes muscle atrophy via decreased muscle protein synthesis and increased protein degradation, leading to frailty and sarcopenia. In this study, we hypothesized that LB extract (LBE) supplementatin has an ameliorative effect on hyperglycemia-induced skeletal muscle damage by activation of 5' adenosine monophosphate-activated protein kinase (AMPK)/sirtuin (SIRT)/proliferator-activated receptor γ coactivator 1α (PGC1α)-associated energy metabolism in mice with T2DM. Diabetes was induced by a high-fat diet with a 2-time streptozotoxin injection (30 mg/kg body weight) in male C57BL/6J mice. After diabetes was induced (fasting blood glucose level ≥140 mg/dL), the mice were administered with LBE at a low dose (100 mg/kg/d) or high dose (250 mg/kg/d) by gavage for 12 weeks. LBE supplementation ameliorated glucose tolerance and hemoglobin A1c (%) in mice with T2DM. Moreover, LBE supplementation upregulated protein levels of insulin receptor subunit-1 and Akt accompanied by increased translocation of glucose transporter 4 in mice with T2DM. Furthermore, LBE increased mitochondrial biogenesis by activating SIRT1, SIRT3, SIRT4, and peroxisome PGC1α in diabetic skeletal muscle. Meanwhile, LBE supplementation reduced oxidative stress and inflammation in mice with T2DM. Taken together, the current study suggested that LBE could be a potential therapeutic to prevent skeletal muscle damage by regulation AMPK/SIRT/PGC1α-related energy metabolism in T2DM." @default.
• W4313252589 created "2023-01-06" @default.
• W4313252589 creator A5012503420 @default.
• W4313252589 creator A5034122721 @default.
• W4313252589 creator A5036629510 @default.
• W4313252589 date "2023-02-01" @default.
• W4313252589 modified "2023-09-30" @default.
• W4313252589 title "Lespedeza bicolor extract supplementation reduced hyperglycemia-induced skeletal muscle damage by regulation of AMPK/SIRT/PGC1α–related energy metabolism in type 2 diabetic mice" @default.
• W4313252589 cites W1524273338 @default.
• W4313252589 cites W1970060454 @default.
• W4313252589 cites W1972557285 @default.
• W4313252589 cites W1977548231 @default.
• W4313252589 cites W1977713833 @default.
• W4313252589 cites W1984540205 @default.
• W4313252589 cites W1985085446 @default.
• W4313252589 cites W2021343620 @default.
• W4313252589 cites W2047831763 @default.
• W4313252589 cites W2048488935 @default.
• W4313252589 cites W2050315451 @default.
• W4313252589 cites W2077908710 @default.
• W4313252589 cites W2119971725 @default.
• W4313252589 cites W2124813430 @default.
• W4313252589 cites W2125516734 @default.
• W4313252589 cites W2150922155 @default.
• W4313252589 cites W2159198268 @default.
• W4313252589 cites W2159430439 @default.
• W4313252589 cites W2159581380 @default.
• W4313252589 cites W2161607478 @default.
• W4313252589 cites W2161945884 @default.
• W4313252589 cites W2255865738 @default.
• W4313252589 cites W2321368870 @default.
• W4313252589 cites W2347034027 @default.
• W4313252589 cites W2405506616 @default.
• W4313252589 cites W2462239109 @default.
• W4313252589 cites W2490801415 @default.
• W4313252589 cites W2729391902 @default.
• W4313252589 cites W2732109967 @default.
• W4313252589 cites W2755222341 @default.
• W4313252589 cites W2757669645 @default.
• W4313252589 cites W2789925679 @default.
• W4313252589 cites W2791529386 @default.
• W4313252589 cites W2903705615 @default.
• W4313252589 cites W2912769729 @default.
• W4313252589 cites W2921570078 @default.
• W4313252589 cites W2925182295 @default.
• W4313252589 cites W2991259317 @default.
• W4313252589 cites W3004940756 @default.
• W4313252589 cites W3153593164 @default.
• W4313252589 cites W3213889595 @default.
• W4313252589 cites W44929223 @default.
• W4313252589 doi "https://doi.org/10.1016/j.nutres.2022.12.007" @default.
• W4313252589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36638746" @default.
• W4313252589 hasPublicationYear "2023" @default.
• W4313252589 type Work @default.
• W4313252589 citedByCount "2" @default.
• W4313252589 countsByYear W43132525892023 @default.
• W4313252589 crossrefType "journal-article" @default.
• W4313252589 hasAuthorship W4313252589A5012503420 @default.
• W4313252589 hasAuthorship W4313252589A5034122721 @default.
• W4313252589 hasAuthorship W4313252589A5036629510 @default.
• W4313252589 hasConcept C126322002 @default.
• W4313252589 hasConcept C134018914 @default.
• W4313252589 hasConcept C161573976 @default.
• W4313252589 hasConcept C184235292 @default.
• W4313252589 hasConcept C185592680 @default.
• W4313252589 hasConcept C2776780712 @default.
• W4313252589 hasConcept C2777229759 @default.
• W4313252589 hasConcept C2777391703 @default.
• W4313252589 hasConcept C2777866211 @default.
• W4313252589 hasConcept C2779306644 @default.
• W4313252589 hasConcept C2779959927 @default.
• W4313252589 hasConcept C2780124434 @default.
• W4313252589 hasConcept C28859421 @default.
• W4313252589 hasConcept C55493867 @default.
• W4313252589 hasConcept C71924100 @default.
• W4313252589 hasConcept C86803240 @default.
• W4313252589 hasConcept C97029542 @default.
• W4313252589 hasConceptScore W4313252589C126322002 @default.
• W4313252589 hasConceptScore W4313252589C134018914 @default.
• W4313252589 hasConceptScore W4313252589C161573976 @default.
• W4313252589 hasConceptScore W4313252589C184235292 @default.
• W4313252589 hasConceptScore W4313252589C185592680 @default.
• W4313252589 hasConceptScore W4313252589C2776780712 @default.
• W4313252589 hasConceptScore W4313252589C2777229759 @default.
• W4313252589 hasConceptScore W4313252589C2777391703 @default.
• W4313252589 hasConceptScore W4313252589C2777866211 @default.
• W4313252589 hasConceptScore W4313252589C2779306644 @default.
• W4313252589 hasConceptScore W4313252589C2779959927 @default.
• W4313252589 hasConceptScore W4313252589C2780124434 @default.
• W4313252589 hasConceptScore W4313252589C28859421 @default.
• W4313252589 hasConceptScore W4313252589C55493867 @default.
• W4313252589 hasConceptScore W4313252589C71924100 @default.
• W4313252589 hasConceptScore W4313252589C86803240 @default.
• W4313252589 hasConceptScore W4313252589C97029542 @default.
• W4313252589 hasFunder F4320322349 @default.
• W4313252589 hasLocation W43132525891 @default.
• W4313252589 hasLocation W43132525892 @default.
• W4313252589 hasOpenAccess W4313252589 @default.

• next