FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313254854> ?p ?o ?g. }

• W4313254854 endingPage "123" @default.
• W4313254854 startingPage "114" @default.
• W4313254854 abstract "Granulomatous reactions can be associated with various types of lymphoma, most commonly classic Hodgkin lymphoma (CHL). In some cases, the granulomatous reaction is extensive, obscuring the presence of neoplastic cells and potentially leading to delayed diagnosis and treatment. It is unknown if this subgroup of CHL has any unique clinicopathologic features. Here, we assessed the clinical and pathological features of 20 cases of CHL with a marked granulomatous reaction, defined in this study as granulomas representing ≥50% of the total cellularity/space of the specimen. This cohort of patients showed a male predominance (M:F ratio = 1.9:1) and 75% of patients were older than 40 years. Nineteen (95%) patients presented with lymphadenopathy with the neck/supraclavicular areas being most commonly involved (11/19; 58%). Advanced stage (III-IV) disease and B symptoms were present in 69% and 64% of patients, respectively. The morphologic features of these neoplasms fit best with mixed cellularity type. The Hodgkin and Reed-Sternberg (HRS) cells were positive for CD30, PAX5 (weak), pSTAT3 (80%), CD15 (70%), PD-L1 (67%), EBV-encoded small RNA (EBER)/LMP1 (50%) and CD20 (42%), and were negative for CD3, CD5, CD45, ALK and pERK. The histiocytes of the granulomas were positive for PD-L1 (67%), pSTAT3 (50%), and were negative for pERK and cyclin D1. Next generation sequencing using a 162-gene panel was negative for mutations in 4 cases. With a median follow-up of 58.9 months (range, 3.4-199.2 months), the median overall survival was 111 months and the 5-year overall survival was 78%. In summary, patients with CHL and a marked granulomatous reaction can present a diagnostic challenge and the pathologist must be alert to the possible presence of CHL to avert potential misdiagnosis. The histiocytes in the granulomas frequently express PD-L1, likely through the activation of the JAK/STAT pathway, suggesting a potential role for PD-1 blockade therapy in these patients." @default.
• W4313254854 created "2023-01-06" @default.
• W4313254854 creator A5006583715 @default.
• W4313254854 creator A5010663972 @default.
• W4313254854 creator A5027665368 @default.
• W4313254854 creator A5038345056 @default.
• W4313254854 creator A5046597133 @default.
• W4313254854 creator A5051740273 @default.
• W4313254854 creator A5055404021 @default.
• W4313254854 creator A5057551502 @default.
• W4313254854 creator A5059586906 @default.
• W4313254854 creator A5084812810 @default.
• W4313254854 creator A5090832029 @default.
• W4313254854 date "2023-04-01" @default.
• W4313254854 modified "2023-09-30" @default.
• W4313254854 title "Classic Hodgkin lymphoma with marked granulomatous reaction: A clinicopathologic study of 20 cases" @default.
• W4313254854 cites W1831833796 @default.
• W4313254854 cites W1979066583 @default.
• W4313254854 cites W1980906172 @default.
• W4313254854 cites W1986354050 @default.
• W4313254854 cites W1998073711 @default.
• W4313254854 cites W2024979042 @default.
• W4313254854 cites W2027907558 @default.
• W4313254854 cites W2034400622 @default.
• W4313254854 cites W2043396026 @default.
• W4313254854 cites W2046166066 @default.
• W4313254854 cites W2051083170 @default.
• W4313254854 cites W2068693591 @default.
• W4313254854 cites W2080673593 @default.
• W4313254854 cites W2084047399 @default.
• W4313254854 cites W2089228335 @default.
• W4313254854 cites W2099796731 @default.
• W4313254854 cites W2109001066 @default.
• W4313254854 cites W2114163075 @default.
• W4313254854 cites W2126866144 @default.
• W4313254854 cites W2141194628 @default.
• W4313254854 cites W2147240268 @default.
• W4313254854 cites W2148550568 @default.
• W4313254854 cites W2160313341 @default.
• W4313254854 cites W2165308914 @default.
• W4313254854 cites W2234683072 @default.
• W4313254854 cites W2279561773 @default.
• W4313254854 cites W2317862639 @default.
• W4313254854 cites W2337659275 @default.
• W4313254854 cites W2552750859 @default.
• W4313254854 cites W2612609299 @default.
• W4313254854 cites W2622400061 @default.
• W4313254854 cites W2730295253 @default.
• W4313254854 cites W2753945613 @default.
• W4313254854 cites W2890493276 @default.
• W4313254854 cites W2892618446 @default.
• W4313254854 cites W2896365172 @default.
• W4313254854 cites W2904410802 @default.
• W4313254854 cites W2908895200 @default.
• W4313254854 cites W2966775399 @default.
• W4313254854 cites W3007328740 @default.
• W4313254854 cites W3024153056 @default.
• W4313254854 cites W3033169509 @default.
• W4313254854 cites W3089986529 @default.
• W4313254854 cites W3106515863 @default.
• W4313254854 cites W4205495996 @default.
• W4313254854 cites W4220863575 @default.
• W4313254854 cites W4283381496 @default.
• W4313254854 cites W4283794798 @default.
• W4313254854 doi "https://doi.org/10.1016/j.humpath.2022.12.014" @default.
• W4313254854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36584716" @default.
• W4313254854 hasPublicationYear "2023" @default.
• W4313254854 type Work @default.
• W4313254854 citedByCount "0" @default.
• W4313254854 crossrefType "journal-article" @default.
• W4313254854 hasAuthorship W4313254854A5006583715 @default.
• W4313254854 hasAuthorship W4313254854A5010663972 @default.
• W4313254854 hasAuthorship W4313254854A5027665368 @default.
• W4313254854 hasAuthorship W4313254854A5038345056 @default.
• W4313254854 hasAuthorship W4313254854A5046597133 @default.
• W4313254854 hasAuthorship W4313254854A5051740273 @default.
• W4313254854 hasAuthorship W4313254854A5055404021 @default.
• W4313254854 hasAuthorship W4313254854A5057551502 @default.
• W4313254854 hasAuthorship W4313254854A5059586906 @default.
• W4313254854 hasAuthorship W4313254854A5084812810 @default.
• W4313254854 hasAuthorship W4313254854A5090832029 @default.
• W4313254854 hasConcept C10205521 @default.
• W4313254854 hasConcept C113067387 @default.
• W4313254854 hasConcept C142724271 @default.
• W4313254854 hasConcept C18031839 @default.
• W4313254854 hasConcept C207886595 @default.
• W4313254854 hasConcept C2776804306 @default.
• W4313254854 hasConcept C2779020855 @default.
• W4313254854 hasConcept C2779338263 @default.
• W4313254854 hasConcept C2779390272 @default.
• W4313254854 hasConcept C2781301800 @default.
• W4313254854 hasConcept C28328180 @default.
• W4313254854 hasConcept C2992779791 @default.
• W4313254854 hasConcept C43100952 @default.
• W4313254854 hasConcept C54355233 @default.
• W4313254854 hasConcept C70905583 @default.
• W4313254854 hasConcept C71924100 @default.
• W4313254854 hasConcept C86803240 @default.

• next