Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313254859> ?p ?o ?g. }
- W4313254859 endingPage "111893" @default.
- W4313254859 startingPage "111893" @default.
- W4313254859 abstract "Within the scope of the FANTOM6 consortium, we perform a large-scale knockdown of 200 long non-coding RNAs (lncRNAs) in human induced pluripotent stem cells (iPSCs) and systematically characterize their roles in self-renewal and pluripotency. We find 36 lncRNAs (18%) exhibiting cell growth inhibition. From the knockdown of 123 lncRNAs with transcriptome profiling, 36 lncRNAs (29.3%) show molecular phenotypes. Integrating the molecular phenotypes with chromatin-interaction assays further reveals cis- and trans-interacting partners as potential primary targets. Additionally, cell-type enrichment analysis identifies lncRNAs associated with pluripotency, while the knockdown of LINC02595, CATG00000090305.1, and RP11-148B6.2 modulates colony formation of iPSCs. We compare our results with previously published fibroblasts phenotyping data and find that 2.9% of the lncRNAs exhibit a consistent cell growth phenotype, whereas we observe 58.3% agreement in molecular phenotypes. This highlights that molecular phenotyping is more comprehensive in revealing affected pathways." @default.
- W4313254859 created "2023-01-06" @default.
- W4313254859 creator A5002764413 @default.
- W4313254859 creator A5005925272 @default.
- W4313254859 creator A5007231621 @default.
- W4313254859 creator A5007530779 @default.
- W4313254859 creator A5010077916 @default.
- W4313254859 creator A5018063097 @default.
- W4313254859 creator A5020199512 @default.
- W4313254859 creator A5021721257 @default.
- W4313254859 creator A5028750495 @default.
- W4313254859 creator A5033878772 @default.
- W4313254859 creator A5038545699 @default.
- W4313254859 creator A5042665283 @default.
- W4313254859 creator A5046500680 @default.
- W4313254859 creator A5047548196 @default.
- W4313254859 creator A5051562212 @default.
- W4313254859 creator A5052977047 @default.
- W4313254859 creator A5052986134 @default.
- W4313254859 creator A5054082582 @default.
- W4313254859 creator A5056977265 @default.
- W4313254859 creator A5062148063 @default.
- W4313254859 creator A5065442564 @default.
- W4313254859 creator A5065523652 @default.
- W4313254859 creator A5065565616 @default.
- W4313254859 creator A5065938896 @default.
- W4313254859 creator A5066531799 @default.
- W4313254859 creator A5068173878 @default.
- W4313254859 creator A5069695209 @default.
- W4313254859 creator A5070114673 @default.
- W4313254859 creator A5072131150 @default.
- W4313254859 creator A5079999358 @default.
- W4313254859 creator A5080335151 @default.
- W4313254859 creator A5087720068 @default.
- W4313254859 creator A5089398658 @default.
- W4313254859 creator A5091617694 @default.
- W4313254859 date "2022-12-01" @default.
- W4313254859 modified "2023-10-12" @default.
- W4313254859 title "Antisense-oligonucleotide-mediated perturbation of long non-coding RNA reveals functional features in stem cells and across cell types" @default.
- W4313254859 cites W1903485451 @default.
- W4313254859 cites W1968972130 @default.
- W4313254859 cites W1989800873 @default.
- W4313254859 cites W1999746344 @default.
- W4313254859 cites W2007771322 @default.
- W4313254859 cites W2008695914 @default.
- W4313254859 cites W2015845481 @default.
- W4313254859 cites W2016532505 @default.
- W4313254859 cites W2018250477 @default.
- W4313254859 cites W2029919331 @default.
- W4313254859 cites W2037363723 @default.
- W4313254859 cites W2057346261 @default.
- W4313254859 cites W2086561953 @default.
- W4313254859 cites W2088152986 @default.
- W4313254859 cites W2098370577 @default.
- W4313254859 cites W2099540110 @default.
- W4313254859 cites W2101133358 @default.
- W4313254859 cites W2102619694 @default.
- W4313254859 cites W2114104545 @default.
- W4313254859 cites W2116881442 @default.
- W4313254859 cites W2121895515 @default.
- W4313254859 cites W2138977668 @default.
- W4313254859 cites W2140729960 @default.
- W4313254859 cites W2150098952 @default.
- W4313254859 cites W2160333540 @default.
- W4313254859 cites W2167491742 @default.
- W4313254859 cites W2169456326 @default.
- W4313254859 cites W2179438025 @default.
- W4313254859 cites W2268624619 @default.
- W4313254859 cites W2505384565 @default.
- W4313254859 cites W2561535772 @default.
- W4313254859 cites W2566843361 @default.
- W4313254859 cites W2593488635 @default.
- W4313254859 cites W2744996861 @default.
- W4313254859 cites W2755353730 @default.
- W4313254859 cites W2761275051 @default.
- W4313254859 cites W2765241643 @default.
- W4313254859 cites W2783011989 @default.
- W4313254859 cites W2799709858 @default.
- W4313254859 cites W2800290862 @default.
- W4313254859 cites W2888134062 @default.
- W4313254859 cites W2901440495 @default.
- W4313254859 cites W2912031480 @default.
- W4313254859 cites W2943588752 @default.
- W4313254859 cites W2954027569 @default.
- W4313254859 cites W2962748610 @default.
- W4313254859 cites W2998984689 @default.
- W4313254859 cites W3000081631 @default.
- W4313254859 cites W3000413306 @default.
- W4313254859 cites W3008598131 @default.
- W4313254859 cites W3014773636 @default.
- W4313254859 cites W3034385380 @default.
- W4313254859 cites W3045704485 @default.
- W4313254859 cites W3046087669 @default.
- W4313254859 cites W3084058862 @default.
- W4313254859 cites W3088940928 @default.
- W4313254859 cites W3092670304 @default.
- W4313254859 cites W3131055609 @default.
- W4313254859 cites W3138396846 @default.