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• W4313255046 endingPage "213268" @default.
• W4313255046 startingPage "213268" @default.
• W4313255046 abstract "The potential therapeutic implications of nitric oxide (NO) have drawn a great deal of interest for reversing multidrug resistance (MDR) in cancer; however, previous strategies utilized unstable or toxic NO donors often oxidized by the excessive addition of reactive oxygen species, leading to unexpected side effects. Therefore, this study proposed a metal-organic framework (MOF), Porous coordination network (PCN)-223-Fe, to be loaded with a biocompatible NO donor, L-arginine (L-arg; i.e., PCN-223-Fe/L-arg). This specific MOF possesses a ligand of Fe-porphyrin, a biomimetic catalyst. Thus, with PCN-223-Fe/L-arg, L-arg was released in a sustained manner, which generated NO by a catalytic reaction between L-arg and Fe-porphyrin in PCN-223-Fe. Through this biomimetic process, PCN-223-Fe/L-arg could generate sufficient NO to reverse MDR at the expense of hydrogen peroxide already present and highly expressed in cancer environments. For treatment of MDR cancer, this study also proposed PCN-223-Fe loaded with an anticancer drug, irinotecan (CPT-11; i.e., PCN-223-Fe/CPT-11), to be formulated together with PCN-223-Fe/L-arg. Owing to the synergistic effect of reversed MDR by NO generation and sustained release of CPT-11, this combined formulation exhibited a higher anticancer effect on MDR cancer cells (MCF-7/ADR). When intratumorally injected in vivo, coadministration of PCN-223-Fe/L-arg and PCN-223-Fe/CPT-11 greatly suppressed tumor growth in nude mice bearing MDR tumors." @default.
• W4313255046 created "2023-01-06" @default.
• W4313255046 creator A5000754818 @default.
• W4313255046 creator A5019758327 @default.
• W4313255046 creator A5022843563 @default.
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• W4313255046 creator A5052557750 @default.
• W4313255046 creator A5055486628 @default.
• W4313255046 creator A5075200035 @default.
• W4313255046 date "2023-02-01" @default.
• W4313255046 modified "2023-09-24" @default.
• W4313255046 title "Metal-organic framework for biomimetic nitric oxide generation and anticancer drug delivery" @default.
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• W4313255046 cites W127488145 @default.
• W4313255046 cites W1505612226 @default.
• W4313255046 cites W1593672322 @default.
• W4313255046 cites W1847584082 @default.
• W4313255046 cites W1932514696 @default.
• W4313255046 cites W1952263528 @default.
• W4313255046 cites W1955562881 @default.
• W4313255046 cites W1968856742 @default.
• W4313255046 cites W1970838453 @default.
• W4313255046 cites W1971377175 @default.
• W4313255046 cites W1978192673 @default.
• W4313255046 cites W1985498995 @default.
• W4313255046 cites W1986531390 @default.
• W4313255046 cites W1988205388 @default.
• W4313255046 cites W1991130662 @default.
• W4313255046 cites W1993482433 @default.
• W4313255046 cites W2006434892 @default.
• W4313255046 cites W2012431429 @default.
• W4313255046 cites W2013546431 @default.
• W4313255046 cites W2023275162 @default.
• W4313255046 cites W2026954356 @default.
• W4313255046 cites W2039156268 @default.
• W4313255046 cites W2042574165 @default.
• W4313255046 cites W2046499682 @default.
• W4313255046 cites W2049811880 @default.
• W4313255046 cites W2059421093 @default.
• W4313255046 cites W2061848028 @default.
• W4313255046 cites W2063496385 @default.
• W4313255046 cites W2066991705 @default.
• W4313255046 cites W2067881562 @default.
• W4313255046 cites W2071411920 @default.
• W4313255046 cites W2072347937 @default.
• W4313255046 cites W2078504463 @default.
• W4313255046 cites W2109680930 @default.
• W4313255046 cites W2115749410 @default.
• W4313255046 cites W2123811338 @default.
• W4313255046 cites W2152368724 @default.
• W4313255046 cites W2155438922 @default.
• W4313255046 cites W2287570000 @default.
• W4313255046 cites W2290746406 @default.
• W4313255046 cites W2465873334 @default.
• W4313255046 cites W2529918369 @default.
• W4313255046 cites W2567338548 @default.
• W4313255046 cites W2588921633 @default.
• W4313255046 cites W2598761550 @default.
• W4313255046 cites W2739822974 @default.
• W4313255046 cites W2755219721 @default.
• W4313255046 cites W2762519070 @default.
• W4313255046 cites W2769689904 @default.
• W4313255046 cites W2777183436 @default.
• W4313255046 cites W2790228691 @default.
• W4313255046 cites W2797902184 @default.
• W4313255046 cites W2887070025 @default.
• W4313255046 cites W2890929093 @default.
• W4313255046 cites W2898522442 @default.
• W4313255046 cites W2899114650 @default.
• W4313255046 cites W2927112364 @default.
• W4313255046 cites W2942983941 @default.
• W4313255046 cites W2948370733 @default.
• W4313255046 cites W2949697021 @default.
• W4313255046 cites W2963087302 @default.
• W4313255046 cites W2974459221 @default.
• W4313255046 cites W2977904261 @default.
• W4313255046 cites W2986251383 @default.
• W4313255046 cites W3000160856 @default.
• W4313255046 cites W3004318250 @default.
• W4313255046 cites W3021909056 @default.
• W4313255046 cites W3025144030 @default.
• W4313255046 cites W3028148512 @default.
• W4313255046 cites W3028303611 @default.
• W4313255046 cites W3044794703 @default.
• W4313255046 cites W3080346016 @default.
• W4313255046 cites W3089159270 @default.
• W4313255046 cites W3115481669 @default.
• W4313255046 cites W3119647280 @default.
• W4313255046 cites W3120773936 @default.
• W4313255046 cites W3145269968 @default.
• W4313255046 cites W3156944167 @default.
• W4313255046 cites W4220682502 @default.
• W4313255046 cites W4221002916 @default.
• W4313255046 cites W4245890986 @default.
• W4313255046 cites W4253859681 @default.
• W4313255046 doi "https://doi.org/10.1016/j.bioadv.2022.213268" @default.
• W4313255046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36580769" @default.

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