FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313255103> ?p ?o ?g. }

• W4313255103 endingPage "111878" @default.
• W4313255103 startingPage "111878" @default.
• W4313255103 abstract "SMAD4 is frequently mutated and inactivated in human gastric cancer (GC). Although the epithelial cell-autonomous functions of Smad4 have been extensively studied, its contribution to tumor immunity is largely undetermined. Here, we report that the loss of Smad4 expression in GC cells endows them with the ability to evade tumor immunity. Unlike their Smad4-proficient counterparts, Smad4-deficient stomach organoids can evade host immunity to form tumors in immunocompetent mice. Smad4-deficient GC cells show expanded CD133+ cancer stem-like cells while suppressing dendritic cell (DC) differentiation and cytotoxic T cells with granulocytic myeloid-derived suppressor cell (G-MDSC) accumulation through a secretome containing CXCL1. Moreover, Smad4 deficiency increases programmed cell death ligand-1 (PD-L1) and decreases 4-1BBL expressions, indicating a change in immunogenicity. Combinatorial immune checkpoint blockade (ICB) of anti-PD-L1 and anti-CTLA-4 or agonistic anti-4-1BB antibodies effectively treats ICB monotherapy-resistant Smad4-deficient allografts, exposing a specific vulnerability. Collectively, these data provide a rational basis for ICB strategies in treating advanced GC with Smad4 deficiency." @default.
• W4313255103 created "2023-01-06" @default.
• W4313255103 creator A5000048957 @default.
• W4313255103 creator A5017575931 @default.
• W4313255103 creator A5024854187 @default.
• W4313255103 creator A5025400440 @default.
• W4313255103 creator A5032392611 @default.
• W4313255103 creator A5044993797 @default.
• W4313255103 creator A5057299922 @default.
• W4313255103 creator A5073793918 @default.
• W4313255103 date "2022-12-01" @default.
• W4313255103 modified "2023-10-14" @default.
• W4313255103 title "The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer" @default.
• W4313255103 cites W1585095072 @default.
• W4313255103 cites W1969083619 @default.
• W4313255103 cites W2031211461 @default.
• W4313255103 cites W2031770999 @default.
• W4313255103 cites W2049923776 @default.
• W4313255103 cites W2062929087 @default.
• W4313255103 cites W2066140100 @default.
• W4313255103 cites W2068174086 @default.
• W4313255103 cites W2075201743 @default.
• W4313255103 cites W2091742850 @default.
• W4313255103 cites W2099880623 @default.
• W4313255103 cites W2103965486 @default.
• W4313255103 cites W2107518278 @default.
• W4313255103 cites W2126547130 @default.
• W4313255103 cites W2129644533 @default.
• W4313255103 cites W2131395804 @default.
• W4313255103 cites W2151832198 @default.
• W4313255103 cites W2154283358 @default.
• W4313255103 cites W2158979552 @default.
• W4313255103 cites W2238949050 @default.
• W4313255103 cites W2416518053 @default.
• W4313255103 cites W2461252756 @default.
• W4313255103 cites W2595182131 @default.
• W4313255103 cites W2608625783 @default.
• W4313255103 cites W2620634247 @default.
• W4313255103 cites W2765224588 @default.
• W4313255103 cites W2767731416 @default.
• W4313255103 cites W2793364080 @default.
• W4313255103 cites W2801251503 @default.
• W4313255103 cites W2883552436 @default.
• W4313255103 cites W2884397450 @default.
• W4313255103 cites W2886987811 @default.
• W4313255103 cites W2889051661 @default.
• W4313255103 cites W2999331749 @default.
• W4313255103 cites W3021979270 @default.
• W4313255103 cites W3080758793 @default.
• W4313255103 cites W3120745011 @default.
• W4313255103 cites W3129646946 @default.
• W4313255103 cites W3134106723 @default.
• W4313255103 cites W3134438200 @default.
• W4313255103 cites W3165782862 @default.
• W4313255103 cites W3173451294 @default.
• W4313255103 cites W3192812059 @default.
• W4313255103 doi "https://doi.org/10.1016/j.celrep.2022.111878" @default.
• W4313255103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36577366" @default.
• W4313255103 hasPublicationYear "2022" @default.
• W4313255103 type Work @default.
• W4313255103 citedByCount "3" @default.
• W4313255103 countsByYear W43132551032023 @default.
• W4313255103 crossrefType "journal-article" @default.
• W4313255103 hasAuthorship W4313255103A5000048957 @default.
• W4313255103 hasAuthorship W4313255103A5017575931 @default.
• W4313255103 hasAuthorship W4313255103A5024854187 @default.
• W4313255103 hasAuthorship W4313255103A5025400440 @default.
• W4313255103 hasAuthorship W4313255103A5032392611 @default.
• W4313255103 hasAuthorship W4313255103A5044993797 @default.
• W4313255103 hasAuthorship W4313255103A5057299922 @default.
• W4313255103 hasAuthorship W4313255103A5073793918 @default.
• W4313255103 hasBestOaLocation W43132551031 @default.
• W4313255103 hasConcept C121608353 @default.
• W4313255103 hasConcept C13373296 @default.
• W4313255103 hasConcept C154317977 @default.
• W4313255103 hasConcept C202751555 @default.
• W4313255103 hasConcept C203014093 @default.
• W4313255103 hasConcept C2776090121 @default.
• W4313255103 hasConcept C2777701055 @default.
• W4313255103 hasConcept C2778170410 @default.
• W4313255103 hasConcept C2780674031 @default.
• W4313255103 hasConcept C2780851360 @default.
• W4313255103 hasConcept C2780868878 @default.
• W4313255103 hasConcept C502942594 @default.
• W4313255103 hasConcept C54355233 @default.
• W4313255103 hasConcept C55493867 @default.
• W4313255103 hasConcept C86803240 @default.
• W4313255103 hasConcept C8891405 @default.
• W4313255103 hasConcept C96525457 @default.
• W4313255103 hasConceptScore W4313255103C121608353 @default.
• W4313255103 hasConceptScore W4313255103C13373296 @default.
• W4313255103 hasConceptScore W4313255103C154317977 @default.
• W4313255103 hasConceptScore W4313255103C202751555 @default.
• W4313255103 hasConceptScore W4313255103C203014093 @default.
• W4313255103 hasConceptScore W4313255103C2776090121 @default.
• W4313255103 hasConceptScore W4313255103C2777701055 @default.
• W4313255103 hasConceptScore W4313255103C2778170410 @default.
• W4313255103 hasConceptScore W4313255103C2780674031 @default.

• next