Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313255237> ?p ?o ?g. }
- W4313255237 endingPage "121990" @default.
- W4313255237 startingPage "121990" @default.
- W4313255237 abstract "Bone regeneration is a highly synchronized process that requires multiple biochemical, bioelectrical, mechanical, and other physiological cues. The restoration and delivery of electrical cues locally through piezoelectric materials have been demonstrated to facilitate osteogenesis in vitro and bone repair in vivo. However, the underlying mechanism by which piezoelectric stimulation promotes osteogenesis and bone repair remains unclear yet, limiting the design and clinical application of piezoelectric materials for bone repair. Herein, a piezoelectric BaTiO3/Ti6Al4V (BT/Ti) scaffold was prepared by hydrothermal synthesis of a uniform BaTiO3 layer on three dimensionally printed Ti6Al4V scaffold. The BT/Ti scaffolds exhibited piezoelectricity and favorable biocompatibility with RAW264.7 macrophages after polarization. In vitro results demonstrated that the piezoelectric effects of the poled BT/Ti scaffolds promoted M2 polarization of macrophages and immunoregulatory osteogenesis of MC-3T3 osteoblasts. In a subcutaneous implantation model, a higher proportion of CD68+ CD206+ M2 macrophages was observed in the tissues around the poled BT/Ti scaffolds under low intensity pulsed ultrasound (LIPUS) stimulation. Improvements in macrophage M2 polarization and bone regeneration were further identified in a sheep cervical corpectomy model. RNA sequencing and mechanistic investigation revealed that the piezoelectric BT/Ti (poled) scaffolds inhibited the inflammatory MAPK/JNK signaling cascade and activated oxidative phosphorylation (OXPHOS) and ATP synthesis in macrophages. Collectively, our study provides a promising method for regulating the immune microenvironment and enhancing bone regeneration using polarized piezoelectric BT/Ti scaffolds." @default.
- W4313255237 created "2023-01-06" @default.
- W4313255237 creator A5001244198 @default.
- W4313255237 creator A5016250459 @default.
- W4313255237 creator A5017990705 @default.
- W4313255237 creator A5023435796 @default.
- W4313255237 creator A5024695372 @default.
- W4313255237 creator A5026323681 @default.
- W4313255237 creator A5030202879 @default.
- W4313255237 creator A5032001037 @default.
- W4313255237 creator A5033224676 @default.
- W4313255237 creator A5037353267 @default.
- W4313255237 creator A5043363677 @default.
- W4313255237 creator A5043839950 @default.
- W4313255237 creator A5046385328 @default.
- W4313255237 creator A5057513398 @default.
- W4313255237 creator A5082674232 @default.
- W4313255237 date "2023-02-01" @default.
- W4313255237 modified "2023-10-18" @default.
- W4313255237 title "Electrical stimulation of piezoelectric BaTiO3 coated Ti6Al4V scaffolds promotes anti-inflammatory polarization of macrophages and bone repair via MAPK/JNK inhibition and OXPHOS activation" @default.
- W4313255237 cites W1822656157 @default.
- W4313255237 cites W1989090840 @default.
- W4313255237 cites W2028817196 @default.
- W4313255237 cites W2036982031 @default.
- W4313255237 cites W2076272449 @default.
- W4313255237 cites W2077814524 @default.
- W4313255237 cites W2167830630 @default.
- W4313255237 cites W2176516365 @default.
- W4313255237 cites W2230487954 @default.
- W4313255237 cites W2319009721 @default.
- W4313255237 cites W2530726117 @default.
- W4313255237 cites W2760815328 @default.
- W4313255237 cites W2776614071 @default.
- W4313255237 cites W2780352665 @default.
- W4313255237 cites W2782580194 @default.
- W4313255237 cites W2788598167 @default.
- W4313255237 cites W2795279419 @default.
- W4313255237 cites W2802330289 @default.
- W4313255237 cites W2915240633 @default.
- W4313255237 cites W2943302727 @default.
- W4313255237 cites W2982665975 @default.
- W4313255237 cites W3024646272 @default.
- W4313255237 cites W3034721086 @default.
- W4313255237 cites W3099950011 @default.
- W4313255237 cites W3113909000 @default.
- W4313255237 cites W3129829621 @default.
- W4313255237 cites W3158399089 @default.
- W4313255237 cites W3159049569 @default.
- W4313255237 cites W3161474660 @default.
- W4313255237 cites W3168169789 @default.
- W4313255237 cites W3168981793 @default.
- W4313255237 cites W3170653193 @default.
- W4313255237 cites W3183317072 @default.
- W4313255237 cites W3196187004 @default.
- W4313255237 cites W3200744154 @default.
- W4313255237 cites W3208498242 @default.
- W4313255237 cites W4200142236 @default.
- W4313255237 cites W4214748463 @default.
- W4313255237 cites W4214818685 @default.
- W4313255237 cites W4220712054 @default.
- W4313255237 cites W4283579191 @default.
- W4313255237 cites W4285736224 @default.
- W4313255237 cites W4287511918 @default.
- W4313255237 cites W4301185081 @default.
- W4313255237 doi "https://doi.org/10.1016/j.biomaterials.2022.121990" @default.
- W4313255237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36586147" @default.
- W4313255237 hasPublicationYear "2023" @default.
- W4313255237 type Work @default.
- W4313255237 citedByCount "15" @default.
- W4313255237 countsByYear W43132552372023 @default.
- W4313255237 crossrefType "journal-article" @default.
- W4313255237 hasAuthorship W4313255237A5001244198 @default.
- W4313255237 hasAuthorship W4313255237A5016250459 @default.
- W4313255237 hasAuthorship W4313255237A5017990705 @default.
- W4313255237 hasAuthorship W4313255237A5023435796 @default.
- W4313255237 hasAuthorship W4313255237A5024695372 @default.
- W4313255237 hasAuthorship W4313255237A5026323681 @default.
- W4313255237 hasAuthorship W4313255237A5030202879 @default.
- W4313255237 hasAuthorship W4313255237A5032001037 @default.
- W4313255237 hasAuthorship W4313255237A5033224676 @default.
- W4313255237 hasAuthorship W4313255237A5037353267 @default.
- W4313255237 hasAuthorship W4313255237A5043363677 @default.
- W4313255237 hasAuthorship W4313255237A5043839950 @default.
- W4313255237 hasAuthorship W4313255237A5046385328 @default.
- W4313255237 hasAuthorship W4313255237A5057513398 @default.
- W4313255237 hasAuthorship W4313255237A5082674232 @default.
- W4313255237 hasConcept C100082104 @default.
- W4313255237 hasConcept C105702510 @default.
- W4313255237 hasConcept C136229726 @default.
- W4313255237 hasConcept C159985019 @default.
- W4313255237 hasConcept C171056886 @default.
- W4313255237 hasConcept C192562407 @default.
- W4313255237 hasConcept C49892992 @default.
- W4313255237 hasConcept C71924100 @default.
- W4313255237 hasConcept C8337478 @default.
- W4313255237 hasConcept C86803240 @default.
- W4313255237 hasConcept C89429830 @default.
- W4313255237 hasConcept C95444343 @default.