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- W4313255504 abstract "Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by stunted growth, cognitive impairment, and increased risk of diverse neurological conditions. Although signs of lifelong neurodegeneration are well documented in DS, the mechanisms underlying this phenotype await elucidation. Here we report a multi-omics analysis of neurodegeneration and neuroinflammation biomarkers, plasma proteomics, and immune profiling in a diverse cohort of more than 400 research participants. We identified depletion of insulin growth factor 1 (IGF1), a master regulator of growth and brain development, as the top biosignature associated with neurodegeneration in DS. Individuals with T21 display chronic IGF1 deficiency downstream of growth hormone production, associated with a specific inflammatory profile involving elevated tumor necrosis factor alpha (TNF-α). Shorter children with DS show stronger IGF1 deficiency, elevated biomarkers of neurodegeneration, and increased prevalence of autism and other conditions. These results point to disruption of IGF1 signaling as a potential contributor to stunted growth and neurodegeneration in DS." @default.
- W4313255504 created "2023-01-06" @default.
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- W4313255504 date "2022-12-01" @default.
- W4313255504 modified "2023-10-16" @default.
- W4313255504 title "IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome" @default.
- W4313255504 cites W1513376696 @default.
- W4313255504 cites W1533188705 @default.
- W4313255504 cites W1578138492 @default.
- W4313255504 cites W1829879414 @default.
- W4313255504 cites W1954003424 @default.
- W4313255504 cites W1963513641 @default.
- W4313255504 cites W1966537913 @default.
- W4313255504 cites W1972160270 @default.
- W4313255504 cites W1975081381 @default.
- W4313255504 cites W1985413489 @default.
- W4313255504 cites W1996331824 @default.
- W4313255504 cites W2002794415 @default.
- W4313255504 cites W2005781341 @default.
- W4313255504 cites W2012115278 @default.
- W4313255504 cites W2014535928 @default.
- W4313255504 cites W2022211568 @default.
- W4313255504 cites W2028951815 @default.
- W4313255504 cites W2035923900 @default.
- W4313255504 cites W2036683667 @default.
- W4313255504 cites W2038601827 @default.
- W4313255504 cites W2052009555 @default.
- W4313255504 cites W2052855366 @default.
- W4313255504 cites W2055883753 @default.
- W4313255504 cites W2056326147 @default.
- W4313255504 cites W2068853602 @default.
- W4313255504 cites W2070684901 @default.
- W4313255504 cites W2073005435 @default.
- W4313255504 cites W2078110880 @default.
- W4313255504 cites W2084575956 @default.
- W4313255504 cites W2101928318 @default.
- W4313255504 cites W2102276155 @default.
- W4313255504 cites W2111894013 @default.
- W4313255504 cites W2113319607 @default.
- W4313255504 cites W2115462905 @default.
- W4313255504 cites W2120880065 @default.
- W4313255504 cites W2128667978 @default.
- W4313255504 cites W2130410032 @default.
- W4313255504 cites W2134774579 @default.
- W4313255504 cites W2135519001 @default.
- W4313255504 cites W2146512944 @default.
- W4313255504 cites W2148928566 @default.
- W4313255504 cites W2161023475 @default.
- W4313255504 cites W2263547832 @default.
- W4313255504 cites W2267968871 @default.
- W4313255504 cites W2331285376 @default.
- W4313255504 cites W2333386541 @default.
- W4313255504 cites W2401136676 @default.
- W4313255504 cites W2487528628 @default.
- W4313255504 cites W2513722645 @default.
- W4313255504 cites W2517549516 @default.
- W4313255504 cites W2524986111 @default.
- W4313255504 cites W2556737993 @default.
- W4313255504 cites W2584289628 @default.
- W4313255504 cites W2609438642 @default.
- W4313255504 cites W2756004609 @default.
- W4313255504 cites W2766826848 @default.
- W4313255504 cites W2772060764 @default.
- W4313255504 cites W2792863859 @default.
- W4313255504 cites W2797389850 @default.
- W4313255504 cites W2803297946 @default.
- W4313255504 cites W2808968956 @default.
- W4313255504 cites W2888898379 @default.
- W4313255504 cites W2900030163 @default.
- W4313255504 cites W2922392173 @default.
- W4313255504 cites W2924533321 @default.
- W4313255504 cites W2927963087 @default.
- W4313255504 cites W2932131298 @default.
- W4313255504 cites W2962105967 @default.
- W4313255504 cites W2963936193 @default.
- W4313255504 cites W2981007674 @default.
- W4313255504 cites W2984925361 @default.
- W4313255504 cites W2988167777 @default.
- W4313255504 cites W2989954543 @default.
- W4313255504 cites W2990944800 @default.
- W4313255504 cites W2991488674 @default.
- W4313255504 cites W3007248785 @default.
- W4313255504 cites W3012636839 @default.
- W4313255504 cites W3027478827 @default.
- W4313255504 cites W3035322587 @default.