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- W4313255540 abstract "Nodularin (NOD) is a harmful cyanotoxin that affects shrimp farming. The hepatopancreas and intestine of shrimp are the main target organs of cyanotoxins. In this study, we exposed Litopenaeus vannamei to NOD at 0.1 and 1 μg/L for 72 h, respectively, and changes in histology, oxidative stress, gene transcription, metabolism, and intestinal microbiota were investigated. After NOD exposure, the hepatopancreas and intestine showed obvious histopathological damage and elevated oxidative stress response. Transcription patterns of immune genes related to detoxification, prophenoloxidase and coagulation system were altered in the hepatopancreas. Furthermore, metabolic patterns, especially amino acid metabolism and arachidonic acid related metabolites, were also disturbed. The integration of differential genes and metabolites revealed that the functions of alanine, aspartic acid and glutamate metabolism and aminoacyl-tRNA biosynthesis were highly affected. Alternatively, NOD exposure induced the variation of the diversity and composition of intestinal microbiota, especially the abundance of potentially beneficial bacteria (Demequina, Phyllobacterium and Pseudoalteromonas) and pathogenic bacteria (Photobacterium and Vibrio). Several intestinal bacteria were correlated with the changes of host the metabolic function and immune factors. These results revealed the toxic effects of NOD on shrimp, and identified some biomarkers." @default.
- W4313255540 created "2023-01-06" @default.
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- W4313255540 date "2023-02-01" @default.
- W4313255540 modified "2023-09-26" @default.
- W4313255540 title "Toxicological response of Pacific white shrimp Litopenaeus vannamei to a hazardous cyanotoxin nodularin exposure" @default.
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- W4313255540 doi "https://doi.org/10.1016/j.envpol.2022.120950" @default.
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