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• W4313255711 abstract "Background and PurposeQuantification of integral radiation dose delivered during treatment for prostate cancer is lacking. We performed a comparative quantification of dose to non-target body tissues delivered via four common radiation techniques: conventional volumetric modulated arc therapy, stereotactic body radiation therapy, pencil-beam scanning proton therapy, and high-dose rate brachytherapy.Materials and MethodsPlans for each radiation technique were generated for ten patients with typical anatomy. For brachytherapy plans, virtual needles were placed to achieve standard dosimetry. Standard planning target volume margins or robustness margins were applied as appropriate. A “normal tissue” structure (entire CT simulation volume minus planning target volume) was generated for integral dose computation. Dose-volume histogram parameters for targets and normal structures were tabulated. Normal tissue integral dose was calculated by multiplying normal tissue volume by mean dose.ResultsNormal tissue integral dose was lowest for brachytherapy. Stereotactic body radiation therapy, pencil-beam scanning protons, and brachytherapy resulted in 17%, 57%, and 91% absolute reductions compared to standard volumetric modulated arc therapy, respectively. Mean non-target tissue receiving 25%, 50%, and 75% of the prescription dose were reduced by 85%, 76%, and 83% for brachytherapy relative to volumetric modulated arc therapy, by 79%, 64%, and 74% relative to stereotactic body radiation therapy, and 73%, 60%, and 81% relative to proton therapy. All reductions observed using brachytherapy were statistically significant.ConclusionHigh-dose rate brachytherapy is an effective technique for reducing dose to non-target body tissues relative to volumetric modulated arc therapy, stereotactic body radiation therapy, and pencil-beam scanning proton therapy. Quantification of integral radiation dose delivered during treatment for prostate cancer is lacking. We performed a comparative quantification of dose to non-target body tissues delivered via four common radiation techniques: conventional volumetric modulated arc therapy, stereotactic body radiation therapy, pencil-beam scanning proton therapy, and high-dose rate brachytherapy. Plans for each radiation technique were generated for ten patients with typical anatomy. For brachytherapy plans, virtual needles were placed to achieve standard dosimetry. Standard planning target volume margins or robustness margins were applied as appropriate. A “normal tissue” structure (entire CT simulation volume minus planning target volume) was generated for integral dose computation. Dose-volume histogram parameters for targets and normal structures were tabulated. Normal tissue integral dose was calculated by multiplying normal tissue volume by mean dose. Normal tissue integral dose was lowest for brachytherapy. Stereotactic body radiation therapy, pencil-beam scanning protons, and brachytherapy resulted in 17%, 57%, and 91% absolute reductions compared to standard volumetric modulated arc therapy, respectively. Mean non-target tissue receiving 25%, 50%, and 75% of the prescription dose were reduced by 85%, 76%, and 83% for brachytherapy relative to volumetric modulated arc therapy, by 79%, 64%, and 74% relative to stereotactic body radiation therapy, and 73%, 60%, and 81% relative to proton therapy. All reductions observed using brachytherapy were statistically significant. High-dose rate brachytherapy is an effective technique for reducing dose to non-target body tissues relative to volumetric modulated arc therapy, stereotactic body radiation therapy, and pencil-beam scanning proton therapy." @default.
• W4313255711 created "2023-01-06" @default.
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• W4313255711 date "2023-05-01" @default.
• W4313255711 modified "2023-10-14" @default.
• W4313255711 title "Normal Tissue Integral Dose as a Result of Prostate Radiation Therapy: A Quantitative Comparison Between High-Dose-Rate Brachytherapy and Modern External Beam Radiation Therapy Techniques" @default.
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• W4313255711 doi "https://doi.org/10.1016/j.adro.2022.101160" @default.
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