Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313256250> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4313256250 endingPage "814" @default.
- W4313256250 startingPage "807" @default.
- W4313256250 abstract "Previously, we have reported that PARP1 rs1136410 is significantly associated with increased the risk of gallbladder cancer.We aimed to investigate the association of PARP1 rs1805405 and rs3219088 polymorphisms with risk of GBC and also association of the haplotype and combined effect of PARP1 SNPs (rs1805405 G/A, rs3219088 G/T and rs1136410 A/G). We have also investigated the expression profile of PARP1 and its correlation with polymorphisms, clinical parameters and overall survival.PARP1 polymorphisms were genotyped by PCR-RFLP and the expression profile of PARP1 at mRNA level was analyzed by semi-quantitative PCR. Overall survival was analyzed using Kaplan-Meier plot and Cox-regression analysis.Haplotype analysis of the PARP1 polymorphisms revealed that AGG, AAG and GGT haplotypes are significantly associated with decreased risk of GBC, while AAT, AGT, GGG and GAG haplotypes are significantly associated with increased risk of GBC. Patients with T1+T2 and treated with chemotherapy having risk genotypes of rs1805405 have decreased overall survival. Upregulation of PARP1 is significantly associated with longer overall survival in patients with GBC with different clinical parameters. SNPs rs1136410 and rs1805405 genotypes are significantly associated with PARP1 expression.Haplotype analysis suggests that PARP1 may have a potential role in gallbladder carcinogenesis." @default.
- W4313256250 created "2023-01-06" @default.
- W4313256250 creator A5004130114 @default.
- W4313256250 creator A5022142737 @default.
- W4313256250 creator A5025038787 @default.
- W4313256250 creator A5052866094 @default.
- W4313256250 creator A5079486307 @default.
- W4313256250 creator A5091159415 @default.
- W4313256250 date "2023-06-01" @default.
- W4313256250 modified "2023-09-27" @default.
- W4313256250 title "Association of haplotype and linkage disequilibrium of PARP1 polymorphisms rs1136410, rs1805405 and rs3219088 with gallbladder cancer" @default.
- W4313256250 cites W1972807178 @default.
- W4313256250 cites W1983090368 @default.
- W4313256250 cites W2018644879 @default.
- W4313256250 cites W2023477758 @default.
- W4313256250 cites W2030447006 @default.
- W4313256250 cites W2043345038 @default.
- W4313256250 cites W2117052740 @default.
- W4313256250 cites W2137573050 @default.
- W4313256250 cites W2163791114 @default.
- W4313256250 cites W2171610467 @default.
- W4313256250 cites W2346634408 @default.
- W4313256250 cites W2924602776 @default.
- W4313256250 cites W2945480038 @default.
- W4313256250 cites W2947190505 @default.
- W4313256250 cites W2955489718 @default.
- W4313256250 cites W2970838954 @default.
- W4313256250 cites W3100519180 @default.
- W4313256250 cites W3112216432 @default.
- W4313256250 cites W3126282329 @default.
- W4313256250 cites W3169022073 @default.
- W4313256250 cites W3180827182 @default.
- W4313256250 cites W3195749226 @default.
- W4313256250 cites W4283763220 @default.
- W4313256250 doi "https://doi.org/10.1016/j.dld.2022.12.006" @default.
- W4313256250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36581511" @default.
- W4313256250 hasPublicationYear "2023" @default.
- W4313256250 type Work @default.
- W4313256250 citedByCount "0" @default.
- W4313256250 crossrefType "journal-article" @default.
- W4313256250 hasAuthorship W4313256250A5004130114 @default.
- W4313256250 hasAuthorship W4313256250A5022142737 @default.
- W4313256250 hasAuthorship W4313256250A5025038787 @default.
- W4313256250 hasAuthorship W4313256250A5052866094 @default.
- W4313256250 hasAuthorship W4313256250A5079486307 @default.
- W4313256250 hasAuthorship W4313256250A5091159415 @default.
- W4313256250 hasConcept C104317684 @default.
- W4313256250 hasConcept C10515644 @default.
- W4313256250 hasConcept C121608353 @default.
- W4313256250 hasConcept C126322002 @default.
- W4313256250 hasConcept C135763542 @default.
- W4313256250 hasConcept C143998085 @default.
- W4313256250 hasConcept C153209595 @default.
- W4313256250 hasConcept C180754005 @default.
- W4313256250 hasConcept C197754878 @default.
- W4313256250 hasConcept C2776534502 @default.
- W4313256250 hasConcept C35605836 @default.
- W4313256250 hasConcept C50382708 @default.
- W4313256250 hasConcept C54355233 @default.
- W4313256250 hasConcept C71924100 @default.
- W4313256250 hasConcept C86803240 @default.
- W4313256250 hasConceptScore W4313256250C104317684 @default.
- W4313256250 hasConceptScore W4313256250C10515644 @default.
- W4313256250 hasConceptScore W4313256250C121608353 @default.
- W4313256250 hasConceptScore W4313256250C126322002 @default.
- W4313256250 hasConceptScore W4313256250C135763542 @default.
- W4313256250 hasConceptScore W4313256250C143998085 @default.
- W4313256250 hasConceptScore W4313256250C153209595 @default.
- W4313256250 hasConceptScore W4313256250C180754005 @default.
- W4313256250 hasConceptScore W4313256250C197754878 @default.
- W4313256250 hasConceptScore W4313256250C2776534502 @default.
- W4313256250 hasConceptScore W4313256250C35605836 @default.
- W4313256250 hasConceptScore W4313256250C50382708 @default.
- W4313256250 hasConceptScore W4313256250C54355233 @default.
- W4313256250 hasConceptScore W4313256250C71924100 @default.
- W4313256250 hasConceptScore W4313256250C86803240 @default.
- W4313256250 hasIssue "6" @default.
- W4313256250 hasLocation W43132562501 @default.
- W4313256250 hasLocation W43132562502 @default.
- W4313256250 hasOpenAccess W4313256250 @default.
- W4313256250 hasPrimaryLocation W43132562501 @default.
- W4313256250 hasRelatedWork W1551477413 @default.
- W4313256250 hasRelatedWork W1966708416 @default.
- W4313256250 hasRelatedWork W2019989714 @default.
- W4313256250 hasRelatedWork W2050501127 @default.
- W4313256250 hasRelatedWork W2050778956 @default.
- W4313256250 hasRelatedWork W2068033436 @default.
- W4313256250 hasRelatedWork W2081569445 @default.
- W4313256250 hasRelatedWork W2154453877 @default.
- W4313256250 hasRelatedWork W2410452464 @default.
- W4313256250 hasRelatedWork W4285586820 @default.
- W4313256250 hasVolume "55" @default.
- W4313256250 isParatext "false" @default.
- W4313256250 isRetracted "false" @default.
- W4313256250 workType "article" @default.