Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313257078> ?p ?o ?g. }
- W4313257078 endingPage "110563" @default.
- W4313257078 startingPage "110563" @default.
- W4313257078 abstract "High expression of the transmembrane receptor IL6ST (gp130) has been identified as a predictive biomarker of endocrine treatment response in ERα-positive breast cancers. To investigate its function further in this disease, this study evaluated the expression, function and signalling of IL6ST in ERα-positive breast cancer cell lines and investigated crosstalk between ERα and IL6ST. IL6ST was differentially expressed in ERα-positive breast cancer cell lines (low in MCF-7, high in ZR751 and T47D), while multiple soluble isoforms of IL6ST were identified. IL6ST is the common signal transducing receptor component for the IL6ST family of cytokines and the effects of seven IL6ST cytokines on these cell lines were studied. These cytokines caused differential growth and migration effects in these cell lines e.g. MCF-7 cells were growth-stimulated, while ZR751 cells were inhibited by IL6 and OSM.. Activation of the STAT and ERK pathways is associated with these responses. Evidence to support trans-signalling involved in cell growth and migration was obtained in both MCF-7 and ZR751 models. Interaction between cytokines and estrogen on ERα-positive cell lines growth were analysed. High expression of IL6ST (in ZR751) may lead to growth inhibition by interacting cytokines while lower expression (in MCF-7) appears associated with proliferation. High IL6ST expression is consistent with a more beneficial clinical outcome if cytokine action contributes to anti-estrogen action." @default.
- W4313257078 created "2023-01-06" @default.
- W4313257078 creator A5012906382 @default.
- W4313257078 creator A5013140743 @default.
- W4313257078 creator A5048450614 @default.
- W4313257078 creator A5054641129 @default.
- W4313257078 creator A5070329763 @default.
- W4313257078 creator A5081401762 @default.
- W4313257078 date "2023-03-01" @default.
- W4313257078 modified "2023-09-30" @default.
- W4313257078 title "Variation in IL6ST cytokine family function and the potential of IL6 trans-signalling in ERα positive breast cancer cells" @default.
- W4313257078 cites W1493770466 @default.
- W4313257078 cites W1495111481 @default.
- W4313257078 cites W1515548981 @default.
- W4313257078 cites W1597588755 @default.
- W4313257078 cites W1966034415 @default.
- W4313257078 cites W1973576115 @default.
- W4313257078 cites W1976379940 @default.
- W4313257078 cites W1979086933 @default.
- W4313257078 cites W1994607862 @default.
- W4313257078 cites W1996803048 @default.
- W4313257078 cites W1997145115 @default.
- W4313257078 cites W1998847200 @default.
- W4313257078 cites W2001941062 @default.
- W4313257078 cites W2010932743 @default.
- W4313257078 cites W2015331193 @default.
- W4313257078 cites W2018261512 @default.
- W4313257078 cites W2018570422 @default.
- W4313257078 cites W2024924098 @default.
- W4313257078 cites W2024929694 @default.
- W4313257078 cites W2049797878 @default.
- W4313257078 cites W2055849383 @default.
- W4313257078 cites W2064855624 @default.
- W4313257078 cites W2093206483 @default.
- W4313257078 cites W2101617873 @default.
- W4313257078 cites W2151658008 @default.
- W4313257078 cites W2162653187 @default.
- W4313257078 cites W2169734442 @default.
- W4313257078 cites W2324496255 @default.
- W4313257078 cites W2404703682 @default.
- W4313257078 cites W2509659139 @default.
- W4313257078 cites W2626842659 @default.
- W4313257078 cites W2631661635 @default.
- W4313257078 cites W2894776217 @default.
- W4313257078 cites W2901335149 @default.
- W4313257078 cites W2944227007 @default.
- W4313257078 cites W3175314996 @default.
- W4313257078 cites W4244158828 @default.
- W4313257078 doi "https://doi.org/10.1016/j.cellsig.2022.110563" @default.
- W4313257078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36565897" @default.
- W4313257078 hasPublicationYear "2023" @default.
- W4313257078 type Work @default.
- W4313257078 citedByCount "1" @default.
- W4313257078 countsByYear W43132570782023 @default.
- W4313257078 crossrefType "journal-article" @default.
- W4313257078 hasAuthorship W4313257078A5012906382 @default.
- W4313257078 hasAuthorship W4313257078A5013140743 @default.
- W4313257078 hasAuthorship W4313257078A5048450614 @default.
- W4313257078 hasAuthorship W4313257078A5054641129 @default.
- W4313257078 hasAuthorship W4313257078A5070329763 @default.
- W4313257078 hasAuthorship W4313257078A5081401762 @default.
- W4313257078 hasBestOaLocation W43132570781 @default.
- W4313257078 hasConcept C121608353 @default.
- W4313257078 hasConcept C126042315 @default.
- W4313257078 hasConcept C162354598 @default.
- W4313257078 hasConcept C203014093 @default.
- W4313257078 hasConcept C2778690821 @default.
- W4313257078 hasConcept C2778923194 @default.
- W4313257078 hasConcept C502942594 @default.
- W4313257078 hasConcept C530470458 @default.
- W4313257078 hasConcept C54355233 @default.
- W4313257078 hasConcept C55493867 @default.
- W4313257078 hasConcept C57074206 @default.
- W4313257078 hasConcept C62112901 @default.
- W4313257078 hasConcept C62478195 @default.
- W4313257078 hasConcept C84606932 @default.
- W4313257078 hasConcept C86803240 @default.
- W4313257078 hasConcept C95444343 @default.
- W4313257078 hasConceptScore W4313257078C121608353 @default.
- W4313257078 hasConceptScore W4313257078C126042315 @default.
- W4313257078 hasConceptScore W4313257078C162354598 @default.
- W4313257078 hasConceptScore W4313257078C203014093 @default.
- W4313257078 hasConceptScore W4313257078C2778690821 @default.
- W4313257078 hasConceptScore W4313257078C2778923194 @default.
- W4313257078 hasConceptScore W4313257078C502942594 @default.
- W4313257078 hasConceptScore W4313257078C530470458 @default.
- W4313257078 hasConceptScore W4313257078C54355233 @default.
- W4313257078 hasConceptScore W4313257078C55493867 @default.
- W4313257078 hasConceptScore W4313257078C57074206 @default.
- W4313257078 hasConceptScore W4313257078C62112901 @default.
- W4313257078 hasConceptScore W4313257078C62478195 @default.
- W4313257078 hasConceptScore W4313257078C84606932 @default.
- W4313257078 hasConceptScore W4313257078C86803240 @default.
- W4313257078 hasConceptScore W4313257078C95444343 @default.
- W4313257078 hasFunder F4320318570 @default.
- W4313257078 hasLocation W43132570781 @default.
- W4313257078 hasLocation W43132570782 @default.
- W4313257078 hasLocation W43132570783 @default.