Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313257095> ?p ?o ?g. }
- W4313257095 endingPage "111873" @default.
- W4313257095 startingPage "111873" @default.
- W4313257095 abstract "Temporal lobe epilepsy is the fourth most common neurological disorder, with about 40% of patients not responding to pharmacological treatment. Increased cellular loss is linked to disease severity and pathological phenotypes such as heightened seizure propensity. While the hippocampus is the target of therapeutic interventions, the impact of the disease at the cellular level remains unclear. Here, we show that hippocampal granule cells change with disease progression as measured in living, resected hippocampal tissue excised from patients with epilepsy. We show that granule cells increase excitability and shorten response latency while also enlarging in cellular volume and spine density. Single-nucleus RNA sequencing combined with simulations ascribes the changes to three conductances: BK, Cav2.2, and Kir2.1. In a network model, we show that these changes related to disease progression bring the circuit into a more excitable state, while reversing them produces a less excitable, early-disease-like state." @default.
- W4313257095 created "2023-01-06" @default.
- W4313257095 creator A5006854970 @default.
- W4313257095 creator A5008813278 @default.
- W4313257095 creator A5011327294 @default.
- W4313257095 creator A5012903805 @default.
- W4313257095 creator A5013070422 @default.
- W4313257095 creator A5016351673 @default.
- W4313257095 creator A5017924092 @default.
- W4313257095 creator A5021624691 @default.
- W4313257095 creator A5028694091 @default.
- W4313257095 creator A5032593226 @default.
- W4313257095 creator A5035033544 @default.
- W4313257095 creator A5042249652 @default.
- W4313257095 creator A5043787754 @default.
- W4313257095 creator A5048985164 @default.
- W4313257095 creator A5051467845 @default.
- W4313257095 creator A5076773889 @default.
- W4313257095 creator A5083458987 @default.
- W4313257095 creator A5085405013 @default.
- W4313257095 creator A5089805066 @default.
- W4313257095 date "2022-12-01" @default.
- W4313257095 modified "2023-10-13" @default.
- W4313257095 title "Multi-modal characterization and simulation of human epileptic circuitry" @default.
- W4313257095 cites W1534933035 @default.
- W4313257095 cites W177658873 @default.
- W4313257095 cites W1921182138 @default.
- W4313257095 cites W1972403208 @default.
- W4313257095 cites W1983219116 @default.
- W4313257095 cites W1984017070 @default.
- W4313257095 cites W1998693870 @default.
- W4313257095 cites W2007860569 @default.
- W4313257095 cites W2013520234 @default.
- W4313257095 cites W2014535438 @default.
- W4313257095 cites W2026062791 @default.
- W4313257095 cites W2038933710 @default.
- W4313257095 cites W2042142350 @default.
- W4313257095 cites W2045270179 @default.
- W4313257095 cites W2047723687 @default.
- W4313257095 cites W2051910050 @default.
- W4313257095 cites W2055655674 @default.
- W4313257095 cites W2069089843 @default.
- W4313257095 cites W2073687720 @default.
- W4313257095 cites W2079295977 @default.
- W4313257095 cites W2107104194 @default.
- W4313257095 cites W2113097895 @default.
- W4313257095 cites W2117120818 @default.
- W4313257095 cites W2117388170 @default.
- W4313257095 cites W2125362348 @default.
- W4313257095 cites W2126829625 @default.
- W4313257095 cites W2128895663 @default.
- W4313257095 cites W2131705496 @default.
- W4313257095 cites W2135077777 @default.
- W4313257095 cites W2146781237 @default.
- W4313257095 cites W2154731415 @default.
- W4313257095 cites W2157784361 @default.
- W4313257095 cites W2165236311 @default.
- W4313257095 cites W2165420548 @default.
- W4313257095 cites W2167993924 @default.
- W4313257095 cites W2317495993 @default.
- W4313257095 cites W2346609767 @default.
- W4313257095 cites W2406391485 @default.
- W4313257095 cites W2598441763 @default.
- W4313257095 cites W2769957205 @default.
- W4313257095 cites W2770339859 @default.
- W4313257095 cites W2885652098 @default.
- W4313257095 cites W2899419202 @default.
- W4313257095 cites W2927507212 @default.
- W4313257095 cites W2969948459 @default.
- W4313257095 cites W3099967679 @default.
- W4313257095 doi "https://doi.org/10.1016/j.celrep.2022.111873" @default.
- W4313257095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36577383" @default.
- W4313257095 hasPublicationYear "2022" @default.
- W4313257095 type Work @default.
- W4313257095 citedByCount "6" @default.
- W4313257095 countsByYear W43132570952023 @default.
- W4313257095 crossrefType "journal-article" @default.
- W4313257095 hasAuthorship W4313257095A5006854970 @default.
- W4313257095 hasAuthorship W4313257095A5008813278 @default.
- W4313257095 hasAuthorship W4313257095A5011327294 @default.
- W4313257095 hasAuthorship W4313257095A5012903805 @default.
- W4313257095 hasAuthorship W4313257095A5013070422 @default.
- W4313257095 hasAuthorship W4313257095A5016351673 @default.
- W4313257095 hasAuthorship W4313257095A5017924092 @default.
- W4313257095 hasAuthorship W4313257095A5021624691 @default.
- W4313257095 hasAuthorship W4313257095A5028694091 @default.
- W4313257095 hasAuthorship W4313257095A5032593226 @default.
- W4313257095 hasAuthorship W4313257095A5035033544 @default.
- W4313257095 hasAuthorship W4313257095A5042249652 @default.
- W4313257095 hasAuthorship W4313257095A5043787754 @default.
- W4313257095 hasAuthorship W4313257095A5048985164 @default.
- W4313257095 hasAuthorship W4313257095A5051467845 @default.
- W4313257095 hasAuthorship W4313257095A5076773889 @default.
- W4313257095 hasAuthorship W4313257095A5083458987 @default.
- W4313257095 hasAuthorship W4313257095A5085405013 @default.
- W4313257095 hasAuthorship W4313257095A5089805066 @default.
- W4313257095 hasBestOaLocation W43132570951 @default.
- W4313257095 hasConcept C142724271 @default.