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• W4313259567 abstract "A novel two-dimensional copper(II) framework (LDU-1), formulated as {[Cu2(L)2·2NMP}n (H2L = flavone-6,2'-dicarboxylic acid, NMP = N-Methyl pyrrolidone), has been constructed under solvothermal conditions and characterized by single-crystal X-ray diffraction, infrared spectroscopy (IR), thermogravimetric analysis and powder X-ray diffraction (PXRD). In the crystal structure, the Cu(II) shows hex-coordinated with the classical Cu paddle-wheel coordination geometry, and the flavonoid ligand coordinates with the Cu(II) ion in a bidentate bridging mode. Of particular interest of LDU-1 is the presence of anti-tumor activity against three human cancer cell lines including lung adenocarcinoma(A549), Michigan cancer foundation-7 (MCF-7), erythroleukemia (K562) and murine melanoma B16F10, indicating synergistic enhancement effects between metal ions and organic linkers. A cell cycle assay indicates that LDU-1 induces cells to arrest at S phase obviously at a lower concentration." @default.
• W4313259567 created "2023-01-06" @default.
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• W4313259567 date "2022-12-23" @default.
• W4313259567 modified "2023-09-30" @default.
• W4313259567 title "The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid" @default.
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• W4313259567 doi "https://doi.org/10.3390/molecules28010129" @default.
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