Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313260055> ?p ?o ?g. }
- W4313260055 endingPage "46" @default.
- W4313260055 startingPage "46" @default.
- W4313260055 abstract "Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML) that is characterized by the PML::RARA fusion or, more rarely, a variant RARA translocation. While APL can be clinically suspected, diagnosis of APL requires genetic confirmation. Targeted therapy such as all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has dramatically improved the prognosis of APL patients, but this is dependent on timely genetic testing as different fusions and/or mutations can affect therapeutic outcomes. Here we report three APL cases with various genetic aberrations: cryptic PML::RARA fusion, variant RARA rearrangement, and typical PML::RARA fusion with co-existing FLT3-ITD mutation. They serve to illustrate the utility of integrating genetic testing, using chromosome analysis, fluorescence in situ hybridization (FISH), reverse transcriptase-polymerase chain reaction (RT-PCR), and next-generation sequencing (NGS) in providing a detailed understanding of the genetic alterations underlying each patient's disease." @default.
- W4313260055 created "2023-01-06" @default.
- W4313260055 creator A5009244884 @default.
- W4313260055 creator A5012841530 @default.
- W4313260055 creator A5014478525 @default.
- W4313260055 creator A5069598069 @default.
- W4313260055 creator A5091012661 @default.
- W4313260055 date "2022-12-23" @default.
- W4313260055 modified "2023-09-30" @default.
- W4313260055 title "Acute Promyelocytic Leukemia with Rare Genetic Aberrations: A Report of Three Cases" @default.
- W4313260055 cites W1553544241 @default.
- W4313260055 cites W1682416068 @default.
- W4313260055 cites W1837808839 @default.
- W4313260055 cites W2015507761 @default.
- W4313260055 cites W2016514994 @default.
- W4313260055 cites W2046705094 @default.
- W4313260055 cites W2060997611 @default.
- W4313260055 cites W2070496138 @default.
- W4313260055 cites W2076638971 @default.
- W4313260055 cites W2083617340 @default.
- W4313260055 cites W2090318710 @default.
- W4313260055 cites W2121931010 @default.
- W4313260055 cites W2131506159 @default.
- W4313260055 cites W2310716991 @default.
- W4313260055 cites W2344085448 @default.
- W4313260055 cites W2414626961 @default.
- W4313260055 cites W2609015272 @default.
- W4313260055 cites W2801146868 @default.
- W4313260055 cites W2893539009 @default.
- W4313260055 cites W2918095490 @default.
- W4313260055 cites W2971458474 @default.
- W4313260055 cites W3009639630 @default.
- W4313260055 cites W3014841253 @default.
- W4313260055 cites W3026937219 @default.
- W4313260055 cites W4224242342 @default.
- W4313260055 cites W4225415210 @default.
- W4313260055 doi "https://doi.org/10.3390/genes14010046" @default.
- W4313260055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36672788" @default.
- W4313260055 hasPublicationYear "2022" @default.
- W4313260055 type Work @default.
- W4313260055 citedByCount "0" @default.
- W4313260055 crossrefType "journal-article" @default.
- W4313260055 hasAuthorship W4313260055A5009244884 @default.
- W4313260055 hasAuthorship W4313260055A5012841530 @default.
- W4313260055 hasAuthorship W4313260055A5014478525 @default.
- W4313260055 hasAuthorship W4313260055A5069598069 @default.
- W4313260055 hasAuthorship W4313260055A5091012661 @default.
- W4313260055 hasBestOaLocation W43132600551 @default.
- W4313260055 hasConcept C104317684 @default.
- W4313260055 hasConcept C111829193 @default.
- W4313260055 hasConcept C138626823 @default.
- W4313260055 hasConcept C190283241 @default.
- W4313260055 hasConcept C2776601000 @default.
- W4313260055 hasConcept C2777542201 @default.
- W4313260055 hasConcept C2778274637 @default.
- W4313260055 hasConcept C2778461978 @default.
- W4313260055 hasConcept C2778729363 @default.
- W4313260055 hasConcept C2780386689 @default.
- W4313260055 hasConcept C2780673598 @default.
- W4313260055 hasConcept C2781121885 @default.
- W4313260055 hasConcept C30481170 @default.
- W4313260055 hasConcept C502942594 @default.
- W4313260055 hasConcept C54355233 @default.
- W4313260055 hasConcept C71924100 @default.
- W4313260055 hasConcept C86803240 @default.
- W4313260055 hasConceptScore W4313260055C104317684 @default.
- W4313260055 hasConceptScore W4313260055C111829193 @default.
- W4313260055 hasConceptScore W4313260055C138626823 @default.
- W4313260055 hasConceptScore W4313260055C190283241 @default.
- W4313260055 hasConceptScore W4313260055C2776601000 @default.
- W4313260055 hasConceptScore W4313260055C2777542201 @default.
- W4313260055 hasConceptScore W4313260055C2778274637 @default.
- W4313260055 hasConceptScore W4313260055C2778461978 @default.
- W4313260055 hasConceptScore W4313260055C2778729363 @default.
- W4313260055 hasConceptScore W4313260055C2780386689 @default.
- W4313260055 hasConceptScore W4313260055C2780673598 @default.
- W4313260055 hasConceptScore W4313260055C2781121885 @default.
- W4313260055 hasConceptScore W4313260055C30481170 @default.
- W4313260055 hasConceptScore W4313260055C502942594 @default.
- W4313260055 hasConceptScore W4313260055C54355233 @default.
- W4313260055 hasConceptScore W4313260055C71924100 @default.
- W4313260055 hasConceptScore W4313260055C86803240 @default.
- W4313260055 hasIssue "1" @default.
- W4313260055 hasLocation W43132600551 @default.
- W4313260055 hasLocation W43132600552 @default.
- W4313260055 hasLocation W43132600553 @default.
- W4313260055 hasOpenAccess W4313260055 @default.
- W4313260055 hasPrimaryLocation W43132600551 @default.
- W4313260055 hasRelatedWork W1981508422 @default.
- W4313260055 hasRelatedWork W2045540313 @default.
- W4313260055 hasRelatedWork W2082121457 @default.
- W4313260055 hasRelatedWork W2082818325 @default.
- W4313260055 hasRelatedWork W2132880845 @default.
- W4313260055 hasRelatedWork W2537508289 @default.
- W4313260055 hasRelatedWork W2904164480 @default.
- W4313260055 hasRelatedWork W3028697823 @default.
- W4313260055 hasRelatedWork W3110852293 @default.
- W4313260055 hasRelatedWork W4366772566 @default.