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- W4313261004 abstract "Our laboratory has been developing a Sindbis viral (SV) vector platform for treatments of ovarian and other types of cancers. In this study we show that SV.IL-12 combined with an agonistic OX40 antibody can eliminate ovarian cancer in a Mouse Ovarian Surface Epithelial Cell Line (MOSEC) model and further prevent tumors in mice rechallenged with tumor cells after approximately 5 months. Treatment efficacy is shown to be dependent upon T-cells that are transcriptionally and metabolically reprogramed. An influx of immune cells to the tumor microenvironment occurs. Combination of sequences encoding both IL-12 and anti-OX40 into a single SV vector, SV.IgGOX40.IL-12, facilitates the local delivery of immunoregulatory agents to tumors enhancing the anti-tumor response. We promote SV.IgGOX40.IL-12 as a safe and effective therapy for multiple types of cancer." @default.
- W4313261004 created "2023-01-06" @default.
- W4313261004 creator A5003504901 @default.
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- W4313261004 creator A5018286718 @default.
- W4313261004 creator A5054647930 @default.
- W4313261004 creator A5071368832 @default.
- W4313261004 date "2022-12-24" @default.
- W4313261004 modified "2023-10-08" @default.
- W4313261004 title "Potent and Targeted Sindbis Virus Platform for Immunotherapy of Ovarian Cancer" @default.
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- W4313261004 doi "https://doi.org/10.3390/cells12010077" @default.
- W4313261004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36611875" @default.
- W4313261004 hasPublicationYear "2022" @default.
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