Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313261041> ?p ?o ?g. }
- W4313261041 endingPage "103" @default.
- W4313261041 startingPage "103" @default.
- W4313261041 abstract "MCC is a rare but highly aggressive skin cancer. The identification of the driving role of Merkel cell polyomavirus (MCPyV) and ultraviolet-induced DNA damage in the oncogenesis of MCC allowed a better understanding of its biological behavior. The presence of MCPyV-specific T cells and lymphocytes exhibiting an 'exhausted' phenotype in the tumor microenvironment along with the high prevalence of immunosuppression among affected patients are strong indicators of the immunogenic properties of MCC. The use of immunotherapy has revolutionized the management of patients with advanced MCC with anti-PD-1/PD L1 blockade, providing objective responses in as much as 50-70% of cases when used in first-line treatment. However, acquired resistance or contraindication to immune checkpoint inhibitors can be an issue for a non-negligible number of patients and novel therapeutic strategies are warranted. This review will focus on current management guidelines for MCC and future therapeutic perspectives for advanced disease with an emphasis on molecular pathways, targeted therapies, and immune-based strategies. These new therapies alone or in combination with anti-PD-1/PD-L1 inhibitors could enhance immune responses against tumor cells and overcome acquired resistance to immunotherapy." @default.
- W4313261041 created "2023-01-06" @default.
- W4313261041 creator A5001799237 @default.
- W4313261041 creator A5001988026 @default.
- W4313261041 creator A5006337734 @default.
- W4313261041 creator A5020847214 @default.
- W4313261041 creator A5035913861 @default.
- W4313261041 creator A5044155540 @default.
- W4313261041 creator A5067733226 @default.
- W4313261041 date "2022-12-23" @default.
- W4313261041 modified "2023-10-16" @default.
- W4313261041 title "Merkel Cell Carcinoma—Update on Diagnosis, Management and Future Perspectives" @default.
- W4313261041 cites W1596392290 @default.
- W4313261041 cites W1718786622 @default.
- W4313261041 cites W1909452331 @default.
- W4313261041 cites W1949115090 @default.
- W4313261041 cites W1965225913 @default.
- W4313261041 cites W1966079723 @default.
- W4313261041 cites W1966536433 @default.
- W4313261041 cites W1983594071 @default.
- W4313261041 cites W1995299847 @default.
- W4313261041 cites W1996583727 @default.
- W4313261041 cites W1996624877 @default.
- W4313261041 cites W2001776535 @default.
- W4313261041 cites W2007807755 @default.
- W4313261041 cites W2009279744 @default.
- W4313261041 cites W2020547644 @default.
- W4313261041 cites W2025323188 @default.
- W4313261041 cites W2025459290 @default.
- W4313261041 cites W2025646725 @default.
- W4313261041 cites W2033128496 @default.
- W4313261041 cites W2037275986 @default.
- W4313261041 cites W2037363625 @default.
- W4313261041 cites W2041546512 @default.
- W4313261041 cites W2046324187 @default.
- W4313261041 cites W2052266670 @default.
- W4313261041 cites W2055648133 @default.
- W4313261041 cites W2056295513 @default.
- W4313261041 cites W2075188110 @default.
- W4313261041 cites W2076963635 @default.
- W4313261041 cites W2084215309 @default.
- W4313261041 cites W2085487956 @default.
- W4313261041 cites W2094107077 @default.
- W4313261041 cites W2101157971 @default.
- W4313261041 cites W2102072494 @default.
- W4313261041 cites W2103939499 @default.
- W4313261041 cites W2108062021 @default.
- W4313261041 cites W2118528405 @default.
- W4313261041 cites W2127554931 @default.
- W4313261041 cites W2132571078 @default.
- W4313261041 cites W2135820830 @default.
- W4313261041 cites W2138173475 @default.
- W4313261041 cites W2141402931 @default.
- W4313261041 cites W2155424734 @default.
- W4313261041 cites W2161872252 @default.
- W4313261041 cites W2164217903 @default.
- W4313261041 cites W2168772214 @default.
- W4313261041 cites W2170169311 @default.
- W4313261041 cites W2283046649 @default.
- W4313261041 cites W2321805081 @default.
- W4313261041 cites W2339890238 @default.
- W4313261041 cites W2407443857 @default.
- W4313261041 cites W2407801378 @default.
- W4313261041 cites W2464667108 @default.
- W4313261041 cites W2510686645 @default.
- W4313261041 cites W2529149350 @default.
- W4313261041 cites W2547701444 @default.
- W4313261041 cites W2560846260 @default.
- W4313261041 cites W2563456874 @default.
- W4313261041 cites W2572079907 @default.
- W4313261041 cites W2575792995 @default.
- W4313261041 cites W2602946883 @default.
- W4313261041 cites W2735267409 @default.
- W4313261041 cites W2739554663 @default.
- W4313261041 cites W2766831098 @default.
- W4313261041 cites W2782946104 @default.
- W4313261041 cites W2785776255 @default.
- W4313261041 cites W2785800563 @default.
- W4313261041 cites W2790018205 @default.
- W4313261041 cites W2792969118 @default.
- W4313261041 cites W2801501875 @default.
- W4313261041 cites W2806816360 @default.
- W4313261041 cites W2886339021 @default.
- W4313261041 cites W2890381807 @default.
- W4313261041 cites W2890527521 @default.
- W4313261041 cites W2894997912 @default.
- W4313261041 cites W2902424322 @default.
- W4313261041 cites W2909550280 @default.
- W4313261041 cites W2943984955 @default.
- W4313261041 cites W2950182878 @default.
- W4313261041 cites W2959607708 @default.
- W4313261041 cites W2964993184 @default.
- W4313261041 cites W2971072835 @default.
- W4313261041 cites W2979054249 @default.
- W4313261041 cites W2998737960 @default.
- W4313261041 cites W3002662929 @default.
- W4313261041 cites W3011138563 @default.
- W4313261041 cites W3015555708 @default.