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- W4313262489 abstract "OBJECTIVES: To report real-world data of a cohort of patients treated with immune-checkpoint inhibitors in Brazil, with focus in immune-related adverse events. MATERIAL AND METHODS: In this retrospective study, we analyzed a cohort of patients with metastatic solid tumors treated at an oncology reference center with at least one dose of immune-checkpoint inhibitors (given as monotherapy or in combination with other agents). The safety pro?le was characterized through the incidence of adverse events, management and hospitalization. RESULTS: We included 185 patients. Immune-related adverse events were observed in 92 of the 185 study patients (49.7%), including 16 patients (8.6%) with such events of grade 3 or 4, and 28 patients (15.1%) requiring systemic corticosteroid therapy. Thyroid disorders (20%), rash (17.8%), pruritus (11.4%) and colitis (11.4%) were the most frequent immune-related adverse events. Five (2.7%) patients discontinued immune-checkpoint inhibitors and 15 (7.0%) were hospitalized due to immune-related adverse events. Development of immune-related adverse events and immune-checkpoint inhibitors used in the ?rst-line setting were associated with prolonged progression-free survival and overall survival in the multivariate analysis. Moreover, age <75 years old and ECOG score 0 or 1 were positively associated with overall survival in the multivariate analysis. CONCLUSION: This study based upon a Brazilian" @default.
- W4313262489 created "2023-01-06" @default.
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- W4313262489 date "2022-01-01" @default.
- W4313262489 modified "2023-09-30" @default.
- W4313262489 title "Patterns of immune-related adverse events in patients treated with immune checkpoint inhibitors: a Brazilian real-world analysis" @default.
- W4313262489 doi "https://doi.org/10.5935/2526-8732.20220367" @default.
- W4313262489 hasPublicationYear "2022" @default.
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