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• W4313266949 endingPage "19" @default.
• W4313266949 startingPage "4" @default.
• W4313266949 abstract "Molecular machines, such as polymerases, ribosomes, or proteasomes, fulfill complex tasks requiring the thermal energy of their environment. They achieve this by restricting random motion along a path of possible conformational changes. These changes are often directed through engagement with different cofactors, which can best be compared to a Brownian ratchet. Many molecular machines undergo three major steps throughout their functional cycles, including initialization, repetitive processing, and termination. Several of these major states have been elucidated by cryogenic electron microscopy (cryo-EM). However, the individual steps for these machines are unique and multistep processes themselves, and their coordination in time is still elusive. To measure these short-lived intermediate events by cryo-EM, the total reaction time needs to be shortened to enrich for the respective pre-equilibrium states. This approach is termed time-resolved cryo-EM (trEM). In this review, we sum up the methodological development of trEM and its application to a range of biological questions." @default.
• W4313266949 created "2023-01-06" @default.
• W4313266949 creator A5017985384 @default.
• W4313266949 creator A5022556961 @default.
• W4313266949 creator A5030961057 @default.
• W4313266949 creator A5085551964 @default.
• W4313266949 creator A5085596530 @default.
• W4313266949 date "2023-01-01" @default.
• W4313266949 modified "2023-10-01" @default.
• W4313266949 title "Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM" @default.
• W4313266949 cites W1539491410 @default.
• W4313266949 cites W1677689941 @default.
• W4313266949 cites W1785940294 @default.
• W4313266949 cites W1978870437 @default.
• W4313266949 cites W1979864007 @default.
• W4313266949 cites W1981880673 @default.
• W4313266949 cites W1985767604 @default.
• W4313266949 cites W1986381105 @default.
• W4313266949 cites W1990501360 @default.
• W4313266949 cites W1992821647 @default.
• W4313266949 cites W1993413544 @default.
• W4313266949 cites W1994306051 @default.
• W4313266949 cites W1995560532 @default.
• W4313266949 cites W2000122627 @default.
• W4313266949 cites W2007214324 @default.
• W4313266949 cites W2010359172 @default.
• W4313266949 cites W2011721714 @default.
• W4313266949 cites W2014670037 @default.
• W4313266949 cites W2022895983 @default.
• W4313266949 cites W2025795956 @default.
• W4313266949 cites W2028968631 @default.
• W4313266949 cites W2032664506 @default.
• W4313266949 cites W2041956358 @default.
• W4313266949 cites W2046889198 @default.
• W4313266949 cites W2048822589 @default.
• W4313266949 cites W2050060197 @default.
• W4313266949 cites W2050292589 @default.
• W4313266949 cites W2054511300 @default.
• W4313266949 cites W2061146689 @default.
• W4313266949 cites W2061327322 @default.
• W4313266949 cites W2063615844 @default.
• W4313266949 cites W2068628797 @default.
• W4313266949 cites W2071849521 @default.
• W4313266949 cites W2073149987 @default.
• W4313266949 cites W2074097219 @default.
• W4313266949 cites W2078668410 @default.
• W4313266949 cites W2078726019 @default.
• W4313266949 cites W2079640150 @default.
• W4313266949 cites W2081556250 @default.
• W4313266949 cites W2081668250 @default.
• W4313266949 cites W2082542708 @default.
• W4313266949 cites W2086899951 @default.
• W4313266949 cites W2093534710 @default.
• W4313266949 cites W2094987467 @default.
• W4313266949 cites W2095098723 @default.
• W4313266949 cites W2099487576 @default.
• W4313266949 cites W2117515977 @default.
• W4313266949 cites W2141158534 @default.
• W4313266949 cites W2143534385 @default.
• W4313266949 cites W2145473270 @default.
• W4313266949 cites W2148504068 @default.
• W4313266949 cites W2185875822 @default.
• W4313266949 cites W2268054573 @default.
• W4313266949 cites W2326272329 @default.
• W4313266949 cites W2340572980 @default.
• W4313266949 cites W2346811503 @default.
• W4313266949 cites W2468882414 @default.
• W4313266949 cites W2533813884 @default.
• W4313266949 cites W2548199696 @default.
• W4313266949 cites W2556628421 @default.
• W4313266949 cites W2581145690 @default.
• W4313266949 cites W2582325127 @default.
• W4313266949 cites W2592535877 @default.
• W4313266949 cites W2614767307 @default.
• W4313266949 cites W2620275628 @default.
• W4313266949 cites W2750714005 @default.
• W4313266949 cites W2784237640 @default.
• W4313266949 cites W2797429729 @default.
• W4313266949 cites W2798011605 @default.
• W4313266949 cites W2802219035 @default.
• W4313266949 cites W2805276053 @default.
• W4313266949 cites W2897820323 @default.
• W4313266949 cites W2899714098 @default.
• W4313266949 cites W2925591784 @default.
• W4313266949 cites W2928370004 @default.
• W4313266949 cites W2934380008 @default.
• W4313266949 cites W2944873741 @default.
• W4313266949 cites W2945292628 @default.
• W4313266949 cites W2949882099 @default.
• W4313266949 cites W2950177365 @default.
• W4313266949 cites W2950782282 @default.
• W4313266949 cites W2951772324 @default.
• W4313266949 cites W2952639737 @default.
• W4313266949 cites W2957093526 @default.
• W4313266949 cites W2965031494 @default.
• W4313266949 cites W2972086226 @default.
• W4313266949 cites W2990715673 @default.
• W4313266949 cites W2991537080 @default.

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