FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313267105> ?p ?o ?g. }

• W4313267105 endingPage "286" @default.
• W4313267105 startingPage "286" @default.
• W4313267105 abstract "Introduction: Since the adoption of pediatric brain death certification in 1987, many legal and ethical dilemmas including practice variations have complicated brain death determination worldwide. We present an infant with a clinical exam consistent with neurologic death yet with intermittent discontinuous background activity on EEG. This case highlights further ethical challenges faced by intensivists in evaluating false positives and negatives in severe neurologic failure. Description: A 32-day-old female presented to the PICU after prolonged out-of-hospital cardiac arrest with fixed and dilated pupils and no spontaneous breathing, cough, or gag reflexes. Post-arrest care was initiated and an EEG was placed with initial very low amplitude to intermittent isoelectric findings, but after 72 hours began to show increased epileptiform activity that transitioned into discontinuous epileptiform activity. On day 20, she had a positive formal apnea test and met clinical criteria after three minutes for death by neurologic criteria. Given previous EEG findings, an EEG was repeated which again showed discontinuous background activity and intermittent low amplitude waves. Discussion: Ancillary testing for brain death is often utilized when a thorough clinical exam or apnea test is not possible. Though EEG was one of the first ancillary tests utilized, reports have suggested a 3.5% chance of false negative in death by neurologic criteria patients. Amongst ancillary tests, EEG has the highest rate of false negative results. The longest documented EEG activity in brain death patients was 14 days, whereas our patient is 3 weeks. Another diagnostic challenge, particularly in neonates, is occurrence of isoelectric findings with an exam not consistent with brain death. These patients may regain minimal cortical function, making institutional policies that use ancillary testing in addition to clinical exam criteria conflicting. In adult brain death guidelines, EEG testing is not recommended as a routine ancillary test due to its lack of sensitivity and specificity; however, it has been retained in many pediatric institutions. Further data is needed to characterize the utility of this practice and bioethical considerations with clinical diagnosis of brain death when isolated electrical activity is present." @default.
• W4313267105 created "2023-01-06" @default.
• W4313267105 creator A5003920513 @default.
• W4313267105 creator A5065412323 @default.
• W4313267105 creator A5082713866 @default.
• W4313267105 creator A5084090825 @default.
• W4313267105 creator A5085938756 @default.
• W4313267105 date "2022-12-15" @default.
• W4313267105 modified "2023-09-24" @default.
• W4313267105 title "595: BRAIN DEATH ANCILLARY TEST: AN ETHICAL DILEMMA" @default.
• W4313267105 doi "https://doi.org/10.1097/01.ccm.0000908108.66108.7e" @default.
• W4313267105 hasPublicationYear "2022" @default.
• W4313267105 type Work @default.
• W4313267105 citedByCount "0" @default.
• W4313267105 crossrefType "journal-article" @default.
• W4313267105 hasAuthorship W4313267105A5003920513 @default.
• W4313267105 hasAuthorship W4313267105A5065412323 @default.
• W4313267105 hasAuthorship W4313267105A5082713866 @default.
• W4313267105 hasAuthorship W4313267105A5084090825 @default.
• W4313267105 hasAuthorship W4313267105A5085938756 @default.
• W4313267105 hasBestOaLocation W43132671051 @default.
• W4313267105 hasConcept C118552586 @default.
• W4313267105 hasConcept C119857082 @default.
• W4313267105 hasConcept C177713679 @default.
• W4313267105 hasConcept C187212893 @default.
• W4313267105 hasConcept C2781326671 @default.
• W4313267105 hasConcept C41008148 @default.
• W4313267105 hasConcept C42219234 @default.
• W4313267105 hasConcept C522805319 @default.
• W4313267105 hasConcept C64869954 @default.
• W4313267105 hasConcept C71924100 @default.
• W4313267105 hasConceptScore W4313267105C118552586 @default.
• W4313267105 hasConceptScore W4313267105C119857082 @default.
• W4313267105 hasConceptScore W4313267105C177713679 @default.
• W4313267105 hasConceptScore W4313267105C187212893 @default.
• W4313267105 hasConceptScore W4313267105C2781326671 @default.
• W4313267105 hasConceptScore W4313267105C41008148 @default.
• W4313267105 hasConceptScore W4313267105C42219234 @default.
• W4313267105 hasConceptScore W4313267105C522805319 @default.
• W4313267105 hasConceptScore W4313267105C64869954 @default.
• W4313267105 hasConceptScore W4313267105C71924100 @default.
• W4313267105 hasIssue "1" @default.
• W4313267105 hasLocation W43132671051 @default.
• W4313267105 hasLocation W43132671052 @default.
• W4313267105 hasOpenAccess W4313267105 @default.
• W4313267105 hasPrimaryLocation W43132671051 @default.
• W4313267105 hasRelatedWork W1966183398 @default.
• W4313267105 hasRelatedWork W2002365818 @default.
• W4313267105 hasRelatedWork W2012521366 @default.
• W4313267105 hasRelatedWork W2029816083 @default.
• W4313267105 hasRelatedWork W2123958797 @default.
• W4313267105 hasRelatedWork W2211841250 @default.
• W4313267105 hasRelatedWork W2549135832 @default.
• W4313267105 hasRelatedWork W3003504927 @default.
• W4313267105 hasRelatedWork W4242858705 @default.
• W4313267105 hasRelatedWork W4252371801 @default.
• W4313267105 hasVolume "51" @default.
• W4313267105 isParatext "false" @default.
• W4313267105 isRetracted "false" @default.
• W4313267105 workType "article" @default.