Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313271736> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4313271736 abstract "ABSTRACT Despite tremendous efforts from the scientific community, pancreatic ductal adenocarcinoma (PDAC) is still a deadly disease and will soon become the second cause of death by cancer worldwide 1 . When surgery is not possible, therapeutic options are few and ineffective 2 . Patients are most often treated with Folfirinox or gemcitabine chemotherapy, that extends survival in weeks to months. Cytidine deaminase (CDA) catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine to fuel RNA and DNA synthesis 3 . CDA also deaminates and neutralizes deoxycytidine-based therapies, and as such, has been identified as a major contributor of tumor chemoresistance, especially to gemcitabine in PDAC 3 . We previously identified that CDA is elevated in PDAC tumors at diagnosis and that CDA exerts an unexpected role on DNA replication that can be exploited for therapeutic intervention 4 . Very recently, CDA was associated with cellular metabolism 5 . Here, we show that CDA promotes mitochondrial biogenesis and oxidative phosphorylation independently of its deaminase activity. This uncloaks novel therapeutic vulnerabilities in primary cancer cells that overexpress this protein. This study shines a new light on the tumoral potential of CDA in PDAC." @default.
- W4313271736 created "2023-01-06" @default.
- W4313271736 creator A5002621255 @default.
- W4313271736 creator A5005975731 @default.
- W4313271736 creator A5006822403 @default.
- W4313271736 creator A5019244535 @default.
- W4313271736 creator A5021453271 @default.
- W4313271736 creator A5038221037 @default.
- W4313271736 creator A5038449100 @default.
- W4313271736 creator A5039389475 @default.
- W4313271736 creator A5048168481 @default.
- W4313271736 creator A5053533004 @default.
- W4313271736 creator A5057553762 @default.
- W4313271736 creator A5069971273 @default.
- W4313271736 creator A5077103144 @default.
- W4313271736 creator A5081053692 @default.
- W4313271736 creator A5086265821 @default.
- W4313271736 date "2022-12-15" @default.
- W4313271736 modified "2023-10-14" @default.
- W4313271736 title "Cytidine deaminase regulates mitochondrial biogenesis in pancreatic cancer cells" @default.
- W4313271736 cites W2043614750 @default.
- W4313271736 cites W2082243154 @default.
- W4313271736 cites W2179438025 @default.
- W4313271736 cites W2278294036 @default.
- W4313271736 cites W2401291964 @default.
- W4313271736 cites W2626421928 @default.
- W4313271736 cites W2800389517 @default.
- W4313271736 cites W2908790954 @default.
- W4313271736 cites W2993084338 @default.
- W4313271736 cites W3009130685 @default.
- W4313271736 cites W3042640874 @default.
- W4313271736 cites W3047089423 @default.
- W4313271736 cites W3146983201 @default.
- W4313271736 cites W3209878191 @default.
- W4313271736 cites W3211402536 @default.
- W4313271736 cites W4245367233 @default.
- W4313271736 cites W4289774748 @default.
- W4313271736 doi "https://doi.org/10.1101/2022.12.15.520429" @default.
- W4313271736 hasPublicationYear "2022" @default.
- W4313271736 type Work @default.
- W4313271736 citedByCount "0" @default.
- W4313271736 crossrefType "posted-content" @default.
- W4313271736 hasAuthorship W4313271736A5002621255 @default.
- W4313271736 hasAuthorship W4313271736A5005975731 @default.
- W4313271736 hasAuthorship W4313271736A5006822403 @default.
- W4313271736 hasAuthorship W4313271736A5019244535 @default.
- W4313271736 hasAuthorship W4313271736A5021453271 @default.
- W4313271736 hasAuthorship W4313271736A5038221037 @default.
- W4313271736 hasAuthorship W4313271736A5038449100 @default.
- W4313271736 hasAuthorship W4313271736A5039389475 @default.
- W4313271736 hasAuthorship W4313271736A5048168481 @default.
- W4313271736 hasAuthorship W4313271736A5053533004 @default.
- W4313271736 hasAuthorship W4313271736A5057553762 @default.
- W4313271736 hasAuthorship W4313271736A5069971273 @default.
- W4313271736 hasAuthorship W4313271736A5077103144 @default.
- W4313271736 hasAuthorship W4313271736A5081053692 @default.
- W4313271736 hasAuthorship W4313271736A5086265821 @default.
- W4313271736 hasBestOaLocation W43132717361 @default.
- W4313271736 hasConcept C121608353 @default.
- W4313271736 hasConcept C181199279 @default.
- W4313271736 hasConcept C185592680 @default.
- W4313271736 hasConcept C2776985229 @default.
- W4313271736 hasConcept C2777844706 @default.
- W4313271736 hasConcept C2779268695 @default.
- W4313271736 hasConcept C2780210213 @default.
- W4313271736 hasConcept C2780258809 @default.
- W4313271736 hasConcept C2781184954 @default.
- W4313271736 hasConcept C502942594 @default.
- W4313271736 hasConcept C54355233 @default.
- W4313271736 hasConcept C55493867 @default.
- W4313271736 hasConcept C86803240 @default.
- W4313271736 hasConceptScore W4313271736C121608353 @default.
- W4313271736 hasConceptScore W4313271736C181199279 @default.
- W4313271736 hasConceptScore W4313271736C185592680 @default.
- W4313271736 hasConceptScore W4313271736C2776985229 @default.
- W4313271736 hasConceptScore W4313271736C2777844706 @default.
- W4313271736 hasConceptScore W4313271736C2779268695 @default.
- W4313271736 hasConceptScore W4313271736C2780210213 @default.
- W4313271736 hasConceptScore W4313271736C2780258809 @default.
- W4313271736 hasConceptScore W4313271736C2781184954 @default.
- W4313271736 hasConceptScore W4313271736C502942594 @default.
- W4313271736 hasConceptScore W4313271736C54355233 @default.
- W4313271736 hasConceptScore W4313271736C55493867 @default.
- W4313271736 hasConceptScore W4313271736C86803240 @default.
- W4313271736 hasLocation W43132717361 @default.
- W4313271736 hasOpenAccess W4313271736 @default.
- W4313271736 hasPrimaryLocation W43132717361 @default.
- W4313271736 hasRelatedWork W1505669602 @default.
- W4313271736 hasRelatedWork W1846314968 @default.
- W4313271736 hasRelatedWork W1975153720 @default.
- W4313271736 hasRelatedWork W2004348534 @default.
- W4313271736 hasRelatedWork W2035788516 @default.
- W4313271736 hasRelatedWork W2106761385 @default.
- W4313271736 hasRelatedWork W2151816755 @default.
- W4313271736 hasRelatedWork W2153833969 @default.
- W4313271736 hasRelatedWork W2167478878 @default.
- W4313271736 hasRelatedWork W2334023189 @default.
- W4313271736 isParatext "false" @default.
- W4313271736 isRetracted "false" @default.
- W4313271736 workType "article" @default.