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• W4313272545 abstract "The gram-negative, zoonotic bacterium Pasteurella multocida was discovered in 1880 and found to be the causative pathogen of fowl cholera. Pasteurella -related diseases can be found in domestic and wild life animals such as buffalo, sheep, goat, deer and antelope, cats, dogs and tigers and cause hemorrhagic septicemia in cattle, rhinitis or pneumonia in rabbits or fowl cholera in poultry and birds. Pasteurella multocida does not play a major role in the immune-competent human host, but can be found after animal bites or in people with close contact to animals. Toxigenic strains are most commonly found in pigs and express a phage-encoded 146 kDa protein, the Pasteurella multocida toxin (PMT). Toxin-expressing strains cause atrophic rhinitis where nasal turbinate bones are destroyed through the inhibition of bone building osteoblasts and the activation of bone resorbing osteoclasts. After its uptake through receptor-mediated endocytosis, PMT specifically targets the alpha subunit of several heterotrimeric G proteins and constitutively activates them through deamidation of a glutamine residue to glutamate in the alpha subunit. This results in cytoskeletal rearrangement, proliferation, differentiation and survival of cells. Because of the toxin’s mitogenic effects, it was suggested that it might have carcinogenic properties, however, no link between Pasteurella infections and cell transformation could be established, neither in tissue culture models nor through epidemiological data. In the recent years it was shown that the toxin not only affects bone, but also the heart as well as basically all cells of innate and adaptive immunity. During the last decade the focus of research shifted from signal transduction processes to understanding how the bacteria might benefit from a bone-destroying toxin. The primary function of PMT seems to be the modulation of immune cell activation which at the same time creates an environment permissive for osteoclast formation. While the disease is restricted to pigs, the implications of the findings from PMT research can be used to explore human diseases and have a high translational potential. In this review our current knowledge will be summarized and it will be discussed what can be learned from using PMT as a tool to understand human pathologies." @default.
• W4313272545 created "2023-01-06" @default.
• W4313272545 creator A5084370353 @default.
• W4313272545 date "2022-12-16" @default.
• W4313272545 modified "2023-10-16" @default.
• W4313272545 title "Pasteurella multocida toxin – lessons learned from a mitogenic toxin" @default.
• W4313272545 cites W114771950 @default.
• W4313272545 cites W1486365785 @default.
• W4313272545 cites W1497124015 @default.
• W4313272545 cites W1508302511 @default.
• W4313272545 cites W1521698573 @default.
• W4313272545 cites W1529674879 @default.
• W4313272545 cites W1536022595 @default.
• W4313272545 cites W1541711227 @default.
• W4313272545 cites W1557942830 @default.
• W4313272545 cites W1567420244 @default.
• W4313272545 cites W1585962162 @default.
• W4313272545 cites W1600270074 @default.
• W4313272545 cites W1603881247 @default.
• W4313272545 cites W1639854378 @default.
• W4313272545 cites W1667550729 @default.
• W4313272545 cites W1672838486 @default.
• W4313272545 cites W1864325817 @default.
• W4313272545 cites W1896097223 @default.
• W4313272545 cites W1909750104 @default.
• W4313272545 cites W1935346479 @default.
• W4313272545 cites W1965305501 @default.
• W4313272545 cites W1966913445 @default.
• W4313272545 cites W1968191137 @default.
• W4313272545 cites W1975505424 @default.
• W4313272545 cites W197850655 @default.
• W4313272545 cites W1982474058 @default.
• W4313272545 cites W1987331822 @default.
• W4313272545 cites W2000229517 @default.
• W4313272545 cites W2001007139 @default.
• W4313272545 cites W2001471351 @default.
• W4313272545 cites W2002225831 @default.
• W4313272545 cites W2004522910 @default.
• W4313272545 cites W2006252043 @default.
• W4313272545 cites W2006828368 @default.
• W4313272545 cites W2015005969 @default.
• W4313272545 cites W2017101260 @default.
• W4313272545 cites W2022714126 @default.
• W4313272545 cites W2037303052 @default.
• W4313272545 cites W2041581065 @default.
• W4313272545 cites W2043522409 @default.
• W4313272545 cites W2043661964 @default.
• W4313272545 cites W2045050595 @default.
• W4313272545 cites W2045223917 @default.
• W4313272545 cites W2045545393 @default.
• W4313272545 cites W2049252550 @default.
• W4313272545 cites W2056414861 @default.
• W4313272545 cites W2057519216 @default.
• W4313272545 cites W2060705160 @default.
• W4313272545 cites W2063318692 @default.
• W4313272545 cites W2069095331 @default.
• W4313272545 cites W2069378448 @default.
• W4313272545 cites W2071092788 @default.
• W4313272545 cites W2072760254 @default.
• W4313272545 cites W2077599263 @default.
• W4313272545 cites W2080594285 @default.
• W4313272545 cites W2086506975 @default.
• W4313272545 cites W2089349963 @default.
• W4313272545 cites W2089937827 @default.
• W4313272545 cites W2096695685 @default.
• W4313272545 cites W2097236919 @default.
• W4313272545 cites W2102426188 @default.
• W4313272545 cites W2107235439 @default.
• W4313272545 cites W2113833365 @default.
• W4313272545 cites W2114117103 @default.
• W4313272545 cites W2115875812 @default.
• W4313272545 cites W2116794225 @default.
• W4313272545 cites W2119211173 @default.
• W4313272545 cites W2125323186 @default.
• W4313272545 cites W2127114287 @default.
• W4313272545 cites W2138354938 @default.
• W4313272545 cites W2138952930 @default.
• W4313272545 cites W2141782563 @default.
• W4313272545 cites W2154767933 @default.
• W4313272545 cites W2154807450 @default.
• W4313272545 cites W2155920085 @default.
• W4313272545 cites W2161794813 @default.
• W4313272545 cites W2163061894 @default.
• W4313272545 cites W2163109266 @default.
• W4313272545 cites W2166757592 @default.
• W4313272545 cites W2167274790 @default.
• W4313272545 cites W2185621807 @default.
• W4313272545 cites W2188775872 @default.
• W4313272545 cites W2192678620 @default.
• W4313272545 cites W2273276607 @default.
• W4313272545 cites W2312354996 @default.
• W4313272545 cites W2313316194 @default.
• W4313272545 cites W2317695120 @default.
• W4313272545 cites W2319187149 @default.
• W4313272545 cites W2412523928 @default.
• W4313272545 cites W2418489262 @default.
• W4313272545 cites W2429507650 @default.
• W4313272545 cites W2532713906 @default.
• W4313272545 cites W2593992158 @default.
• W4313272545 cites W2610193187 @default.

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