Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313274777> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4313274777 abstract "Abstract Introduction: Combining immune checkpoint inhibitor and chemotherapies provides more benefits than traditional treatment options in patients with NSCLC. However, some patients still have no clinical benefits. Clinical accessible biomarkers are necessary to predict clinical outcomes and optimize dose strategies. The study aimed to investigate accessible biomarkers that can predict clinical outcomes and optimize dosing strategies of atezolizumab and nab-paclitaxel combination therapy in patients with NSCLC by quantitative systems pharmacology (QSP). Methods: The model was developed based on a published QSP model of triple-negative breast cancer using the SimBiology toolbox in MATLAB. The model included four compartments. With the model, we generated a virtual patient cohort to conduct in silico virtual clinical trials and used available data from real clinical trials (IMpower131) for model calibration and validation. Results: The final QSP model predictions are consistent with clinically reported efficacy endpoints. CD8+ and CD4+ T cell densities in tumor are significantly affected by the response status. Roc analysis further implicating their potential to be predictive biomarkers for this double combination regimen. Virtual clinical trial simulation shows reduced nab-paclitaxel doses from 100 mg/m2 to 75 mg/m2 would leads to lower ORR but was higher than atezolizumab monotherapy. Three atezolizumab dosing strategies combined with nab-paclitaxel showed comparable efficacy. to compare different schedules of the two drugs for simulated therapeutic optimization. Conclusion: This study provides a QSP model, which can be used to generate virtual patient cohorts and conduct virtual clinical trials. Our findings demonstrate its potential for making efficacy predictions for immunotherapies and chemotherapies, identifying predictive biomarkers, and guiding future clinical trial designs." @default.
- W4313274777 created "2023-01-06" @default.
- W4313274777 creator A5020140924 @default.
- W4313274777 creator A5042866937 @default.
- W4313274777 creator A5049242358 @default.
- W4313274777 creator A5049806492 @default.
- W4313274777 creator A5054986754 @default.
- W4313274777 creator A5060126640 @default.
- W4313274777 creator A5071107989 @default.
- W4313274777 creator A5088242164 @default.
- W4313274777 creator A5091363967 @default.
- W4313274777 date "2022-12-29" @default.
- W4313274777 modified "2023-09-27" @default.
- W4313274777 title "Dose Regimen Optimization of PD-L1 Inhibitor and Nab-paclitaxel in Patients with NSCLC: a Quantitative Systems Pharmacology analysis" @default.
- W4313274777 cites W2567564314 @default.
- W4313274777 cites W2784371446 @default.
- W4313274777 cites W3017322331 @default.
- W4313274777 cites W3126910508 @default.
- W4313274777 doi "https://doi.org/10.21203/rs.3.rs-2403420/v1" @default.
- W4313274777 hasPublicationYear "2022" @default.
- W4313274777 type Work @default.
- W4313274777 citedByCount "0" @default.
- W4313274777 crossrefType "posted-content" @default.
- W4313274777 hasAuthorship W4313274777A5020140924 @default.
- W4313274777 hasAuthorship W4313274777A5042866937 @default.
- W4313274777 hasAuthorship W4313274777A5049242358 @default.
- W4313274777 hasAuthorship W4313274777A5049806492 @default.
- W4313274777 hasAuthorship W4313274777A5054986754 @default.
- W4313274777 hasAuthorship W4313274777A5060126640 @default.
- W4313274777 hasAuthorship W4313274777A5071107989 @default.
- W4313274777 hasAuthorship W4313274777A5088242164 @default.
- W4313274777 hasAuthorship W4313274777A5091363967 @default.
- W4313274777 hasBestOaLocation W43132747771 @default.
- W4313274777 hasConcept C121608353 @default.
- W4313274777 hasConcept C126322002 @default.
- W4313274777 hasConcept C143998085 @default.
- W4313274777 hasConcept C2775949291 @default.
- W4313274777 hasConcept C2777288759 @default.
- W4313274777 hasConcept C2777292972 @default.
- W4313274777 hasConcept C2777701055 @default.
- W4313274777 hasConcept C2778533338 @default.
- W4313274777 hasConcept C2779446555 @default.
- W4313274777 hasConcept C2780030458 @default.
- W4313274777 hasConcept C2780035454 @default.
- W4313274777 hasConcept C2781413609 @default.
- W4313274777 hasConcept C509550671 @default.
- W4313274777 hasConcept C535046627 @default.
- W4313274777 hasConcept C71924100 @default.
- W4313274777 hasConcept C98274493 @default.
- W4313274777 hasConceptScore W4313274777C121608353 @default.
- W4313274777 hasConceptScore W4313274777C126322002 @default.
- W4313274777 hasConceptScore W4313274777C143998085 @default.
- W4313274777 hasConceptScore W4313274777C2775949291 @default.
- W4313274777 hasConceptScore W4313274777C2777288759 @default.
- W4313274777 hasConceptScore W4313274777C2777292972 @default.
- W4313274777 hasConceptScore W4313274777C2777701055 @default.
- W4313274777 hasConceptScore W4313274777C2778533338 @default.
- W4313274777 hasConceptScore W4313274777C2779446555 @default.
- W4313274777 hasConceptScore W4313274777C2780030458 @default.
- W4313274777 hasConceptScore W4313274777C2780035454 @default.
- W4313274777 hasConceptScore W4313274777C2781413609 @default.
- W4313274777 hasConceptScore W4313274777C509550671 @default.
- W4313274777 hasConceptScore W4313274777C535046627 @default.
- W4313274777 hasConceptScore W4313274777C71924100 @default.
- W4313274777 hasConceptScore W4313274777C98274493 @default.
- W4313274777 hasFunder F4320325412 @default.
- W4313274777 hasLocation W43132747771 @default.
- W4313274777 hasOpenAccess W4313274777 @default.
- W4313274777 hasPrimaryLocation W43132747771 @default.
- W4313274777 hasRelatedWork W2012171803 @default.
- W4313274777 hasRelatedWork W2055272681 @default.
- W4313274777 hasRelatedWork W2153557259 @default.
- W4313274777 hasRelatedWork W2289428780 @default.
- W4313274777 hasRelatedWork W2423566731 @default.
- W4313274777 hasRelatedWork W2888392413 @default.
- W4313274777 hasRelatedWork W4234586607 @default.
- W4313274777 hasRelatedWork W4238509468 @default.
- W4313274777 hasRelatedWork W4244943686 @default.
- W4313274777 hasRelatedWork W4308252516 @default.
- W4313274777 isParatext "false" @default.
- W4313274777 isRetracted "false" @default.
- W4313274777 workType "article" @default.