FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313279412> ?p ?o ?g. }

• W4313279412 abstract "Abstract Seven benzophenanthridine alkaloids ( 1–7 ) were obtained from the 75 % EtOH extract of Eomecon chionantha , and exhibited moderate biological activity against MCF‐7 cells. 8,12‐dimethoxysanguinarine ( 1 , DSG) strongly decreased the cell viability of MCF‐7 cell lines with an IC 50 value of 7.12 μΜ. Based on RNA‐sequencing measure and KEGG pathway enrichment analysis results, the significant differentially expressed genes (DEGs) were associated with Pathways in Cancer and PI3 K‐AKT signaling pathways in DSG treated group. The potential molecular regulatory mechanisms underlying the effect of DSG induces necroptosis in MCF‐7 cells via molecular docking, TEM analysis, and ROS measurement. Besides, DEGs of bone metastasis‐related genes such as PI3 K, IGF1R, Notch, and Wnt mRNA were significantly downregulated in the DSG‐treated group on MCF‐7 cells. DSG might be selected as a bone metastasis proteins inhibitor of IL‐1β, IL‐6, IκBα, IGF1R, Notch, NF‐ κ B, PTHrp, PI3 K, PKB/AKT, PTEN, TNF‐α, and Wnt via molecular docking. DSG suppressed bone metastasis by regulating the expression levels of IL‐1β, IL‐6, PTH, CROSS, TP1NP, and OSTEOC on MCF‐7 cells using ELISA measurement. Thus, our findings reveal that DSG could be a lead compound for suppressing tumor cells to bone metastasis in breast cancer cells." @default.
• W4313279412 created "2023-01-06" @default.
• W4313279412 creator A5025578969 @default.
• W4313279412 creator A5071784610 @default.
• W4313279412 creator A5091217057 @default.
• W4313279412 date "2022-12-28" @default.
• W4313279412 modified "2023-09-27" @default.
• W4313279412 title "Cytotoxic Effects of the Benzophenanthridine Alkaloids Isolated from <i>Eomecon chionantha</i> on MCF‐7 Cells and Its Potential Mechanism" @default.
• W4313279412 cites W1967830419 @default.
• W4313279412 cites W1978063609 @default.
• W4313279412 cites W1997066354 @default.
• W4313279412 cites W2053083335 @default.
• W4313279412 cites W2064073012 @default.
• W4313279412 cites W2074997661 @default.
• W4313279412 cites W2078693750 @default.
• W4313279412 cites W2415492320 @default.
• W4313279412 cites W2572688850 @default.
• W4313279412 cites W2742211392 @default.
• W4313279412 cites W2804869876 @default.
• W4313279412 cites W2896909557 @default.
• W4313279412 cites W2898391595 @default.
• W4313279412 cites W2903376111 @default.
• W4313279412 cites W2990876536 @default.
• W4313279412 cites W3017060567 @default.
• W4313279412 cites W3041417701 @default.
• W4313279412 cites W3047082133 @default.
• W4313279412 cites W3048970650 @default.
• W4313279412 cites W3116510596 @default.
• W4313279412 cites W3128089554 @default.
• W4313279412 cites W3129087870 @default.
• W4313279412 cites W3138093594 @default.
• W4313279412 cites W3156782050 @default.
• W4313279412 doi "https://doi.org/10.1002/cbdv.202200871" @default.
• W4313279412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36529680" @default.
• W4313279412 hasPublicationYear "2022" @default.
• W4313279412 type Work @default.
• W4313279412 citedByCount "1" @default.
• W4313279412 countsByYear W43132794122023 @default.
• W4313279412 crossrefType "journal-article" @default.
• W4313279412 hasAuthorship W4313279412A5025578969 @default.
• W4313279412 hasAuthorship W4313279412A5071784610 @default.
• W4313279412 hasAuthorship W4313279412A5091217057 @default.
• W4313279412 hasConcept C109541995 @default.
• W4313279412 hasConcept C11960822 @default.
• W4313279412 hasConcept C121608353 @default.
• W4313279412 hasConcept C137620995 @default.
• W4313279412 hasConcept C153911025 @default.
• W4313279412 hasConcept C185592680 @default.
• W4313279412 hasConcept C190283241 @default.
• W4313279412 hasConcept C2777609662 @default.
• W4313279412 hasConcept C2777783956 @default.
• W4313279412 hasConcept C2779013556 @default.
• W4313279412 hasConcept C2994423619 @default.
• W4313279412 hasConcept C502942594 @default.
• W4313279412 hasConcept C53227056 @default.
• W4313279412 hasConcept C54355233 @default.
• W4313279412 hasConcept C55493867 @default.
• W4313279412 hasConcept C62478195 @default.
• W4313279412 hasConcept C75217442 @default.
• W4313279412 hasConcept C81885089 @default.
• W4313279412 hasConcept C86554907 @default.
• W4313279412 hasConcept C86803240 @default.
• W4313279412 hasConcept C95444343 @default.
• W4313279412 hasConcept C96232424 @default.
• W4313279412 hasConceptScore W4313279412C109541995 @default.
• W4313279412 hasConceptScore W4313279412C11960822 @default.
• W4313279412 hasConceptScore W4313279412C121608353 @default.
• W4313279412 hasConceptScore W4313279412C137620995 @default.
• W4313279412 hasConceptScore W4313279412C153911025 @default.
• W4313279412 hasConceptScore W4313279412C185592680 @default.
• W4313279412 hasConceptScore W4313279412C190283241 @default.
• W4313279412 hasConceptScore W4313279412C2777609662 @default.
• W4313279412 hasConceptScore W4313279412C2777783956 @default.
• W4313279412 hasConceptScore W4313279412C2779013556 @default.
• W4313279412 hasConceptScore W4313279412C2994423619 @default.
• W4313279412 hasConceptScore W4313279412C502942594 @default.
• W4313279412 hasConceptScore W4313279412C53227056 @default.
• W4313279412 hasConceptScore W4313279412C54355233 @default.
• W4313279412 hasConceptScore W4313279412C55493867 @default.
• W4313279412 hasConceptScore W4313279412C62478195 @default.
• W4313279412 hasConceptScore W4313279412C75217442 @default.
• W4313279412 hasConceptScore W4313279412C81885089 @default.
• W4313279412 hasConceptScore W4313279412C86554907 @default.
• W4313279412 hasConceptScore W4313279412C86803240 @default.
• W4313279412 hasConceptScore W4313279412C95444343 @default.
• W4313279412 hasConceptScore W4313279412C96232424 @default.
• W4313279412 hasIssue "1" @default.
• W4313279412 hasLocation W43132794121 @default.
• W4313279412 hasLocation W43132794122 @default.
• W4313279412 hasOpenAccess W4313279412 @default.
• W4313279412 hasPrimaryLocation W43132794121 @default.
• W4313279412 hasRelatedWork W1993312761 @default.
• W4313279412 hasRelatedWork W2022070430 @default.
• W4313279412 hasRelatedWork W2127721237 @default.
• W4313279412 hasRelatedWork W2144556646 @default.
• W4313279412 hasRelatedWork W2145454786 @default.
• W4313279412 hasRelatedWork W2530477428 @default.
• W4313279412 hasRelatedWork W2861688776 @default.
• W4313279412 hasRelatedWork W318955610 @default.
• W4313279412 hasRelatedWork W4313594830 @default.

• next