Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313279503> ?p ?o ?g. }
- W4313279503 endingPage "107712" @default.
- W4313279503 startingPage "107712" @default.
- W4313279503 abstract "Phthalic acid esters (PAEs) are an important group of organic pollutants that are widely used as plasticizers in the environment. The PAEs in soil organisms are likely to be biotransformed into a variety of metabolites, and the combined toxicity of PAEs and their metabolites might be more serious than PAEs alone. However, there are only a few studies on PAE biotransformation by terrestrial animals, e.g. earthworms. Herein, the key biotransformation pathways of PAEs and their association with catalytic enzymes and intestinal symbionts in earthworms were studied using in vivo and in vitro incubation approaches. The widely distributed PAE in soil, dibutyl phthalate (DBP), was proven to be biotransformed rapidly together with apparent bioaccumulation in earthworms. The biotransformation of PAE congeners with medium or long side chains appeared to be faster compared with those with short side chains. DBP was biotransformed into butyl methyl phthalate (BMP), monobutyl phthalate (MBP), and phthalic acid (PA) through esterolysis and transesterification. Besides, the generation of small quantities of low-molecular weight metabolites via β-oxidation, decarboxylation or ring-cleavage, was also observed, especially when the appropriate proportion of NADPH coenzyme was applied to transfer electrons for oxidases. Interestingly, the esterolysis of PAEs was mainly regulated by the cytoplasmic carboxylesterase (CarE) in earthworms, with a Michaelis constant (Km) of 0.416 mM in the catalysis of DBP. The stronger esterolysis in non-intestinal tissues indicated that the CarE was primarily secreted by non-intestinal tissues of earthworms. Additionally, the intestinal symbiotic bacteria of earthworms could respond to PAE stress, leading to the changes in their diversity and composition. The enrichment of some genera e.g. Bacillus and Paracoccus, and the enhancement of metabolism function, e.g. amino acids, energy, lipids biosynthesis and oxidase secretion, indicated their important role in the degradation of PAEs." @default.
- W4313279503 created "2023-01-06" @default.
- W4313279503 creator A5002661071 @default.
- W4313279503 creator A5011340082 @default.
- W4313279503 creator A5024250013 @default.
- W4313279503 creator A5034048893 @default.
- W4313279503 creator A5042748921 @default.
- W4313279503 creator A5051624590 @default.
- W4313279503 creator A5060155177 @default.
- W4313279503 creator A5085600403 @default.
- W4313279503 date "2023-01-01" @default.
- W4313279503 modified "2023-10-05" @default.
- W4313279503 title "Major biotransformation of phthalic acid esters in Eisenia fetida: Mechanistic insights and association with catalytic enzymes and intestinal symbionts" @default.
- W4313279503 cites W1480704794 @default.
- W4313279503 cites W1595590273 @default.
- W4313279503 cites W1720494421 @default.
- W4313279503 cites W1874272765 @default.
- W4313279503 cites W1911203598 @default.
- W4313279503 cites W1976964781 @default.
- W4313279503 cites W1982372562 @default.
- W4313279503 cites W1986246940 @default.
- W4313279503 cites W1990677963 @default.
- W4313279503 cites W1993044653 @default.
- W4313279503 cites W1995269926 @default.
- W4313279503 cites W1997855179 @default.
- W4313279503 cites W1998498873 @default.
- W4313279503 cites W1999994029 @default.
- W4313279503 cites W2000003062 @default.
- W4313279503 cites W2008783999 @default.
- W4313279503 cites W2010011313 @default.
- W4313279503 cites W2012423635 @default.
- W4313279503 cites W2017590245 @default.
- W4313279503 cites W2020716716 @default.
- W4313279503 cites W2022953075 @default.
- W4313279503 cites W2026495805 @default.
- W4313279503 cites W2029339668 @default.
- W4313279503 cites W2030274533 @default.
- W4313279503 cites W2034285706 @default.
- W4313279503 cites W2036918521 @default.
- W4313279503 cites W2042678266 @default.
- W4313279503 cites W2046446621 @default.
- W4313279503 cites W2053430756 @default.
- W4313279503 cites W2054253147 @default.
- W4313279503 cites W2057689554 @default.
- W4313279503 cites W2058759573 @default.
- W4313279503 cites W2061678601 @default.
- W4313279503 cites W2068921679 @default.
- W4313279503 cites W2070744836 @default.
- W4313279503 cites W2071963528 @default.
- W4313279503 cites W2074910209 @default.
- W4313279503 cites W2077631777 @default.
- W4313279503 cites W2078325715 @default.
- W4313279503 cites W2079391597 @default.
- W4313279503 cites W2087145730 @default.
- W4313279503 cites W2088260016 @default.
- W4313279503 cites W2088584756 @default.
- W4313279503 cites W2088833470 @default.
- W4313279503 cites W2092934139 @default.
- W4313279503 cites W2097107919 @default.
- W4313279503 cites W2117457769 @default.
- W4313279503 cites W2131938552 @default.
- W4313279503 cites W2134497368 @default.
- W4313279503 cites W2139526205 @default.
- W4313279503 cites W2156814453 @default.
- W4313279503 cites W2192679502 @default.
- W4313279503 cites W2232979792 @default.
- W4313279503 cites W2280111985 @default.
- W4313279503 cites W2376534274 @default.
- W4313279503 cites W2402163592 @default.
- W4313279503 cites W2417276280 @default.
- W4313279503 cites W2431242864 @default.
- W4313279503 cites W2471643781 @default.
- W4313279503 cites W2527882858 @default.
- W4313279503 cites W2548467801 @default.
- W4313279503 cites W2565045175 @default.
- W4313279503 cites W2568895249 @default.
- W4313279503 cites W2576198781 @default.
- W4313279503 cites W2587214452 @default.
- W4313279503 cites W2620272755 @default.
- W4313279503 cites W2743503482 @default.
- W4313279503 cites W2754272616 @default.
- W4313279503 cites W2761590587 @default.
- W4313279503 cites W2771843428 @default.
- W4313279503 cites W2791174417 @default.
- W4313279503 cites W2794908918 @default.
- W4313279503 cites W2794940880 @default.
- W4313279503 cites W2801788850 @default.
- W4313279503 cites W2803262457 @default.
- W4313279503 cites W2884023930 @default.
- W4313279503 cites W2899405444 @default.
- W4313279503 cites W2904635842 @default.
- W4313279503 cites W2921769556 @default.
- W4313279503 cites W2943909170 @default.
- W4313279503 cites W2945916397 @default.
- W4313279503 cites W2952197103 @default.
- W4313279503 cites W2969359481 @default.
- W4313279503 cites W2989696734 @default.
- W4313279503 cites W3008759506 @default.