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• W4313279519 endingPage "16" @default.
• W4313279519 startingPage "1" @default.
• W4313279519 abstract "The nucleic acid therapeutics field has made tremendous progress in the past decades. Continuous advances in chemistry and design have led to many successful clinical applications, eliciting even more interest from researchers including both academic groups and drug development companies. Many preclinical studies in the field focus on improving the delivery of antisense oligonucleotide drugs (ONDs) and/or assessing their efficacy in target tissues, often neglecting the evaluation of toxicity, at least in early phases of development. A series of consensus recommendations regarding regulatory considerations and expectations have been generated by the Oligonucleotide Safety Working Group and the Japanese Research Working Group for the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use S6 and Related Issues (WGS6) in several white papers. However, safety aspects should also be kept in sight in earlier phases while screening and designing OND to avoid subsequent failure in the development phase. Experts and members of the network “DARTER,” a COST Action funded by the Cooperation in Science and Technology of the EU, have utilized their collective experience working with OND, as well as their insights into OND-mediated toxicities, to generate a series of consensus recommendations to assess OND toxicity in early stages of preclinical research. In the past few years, several publications have described predictive assays, which can be used to assess OND-mediated toxicity in vitro or ex vivo to filter out potential toxic candidates before moving to in vivo phases of preclinical development, that is, animal toxicity studies. These assays also have the potential to provide translational insight since they allow a safety evaluation in human in vitro systems. Yet, small preliminary in vivo studies should also be considered to complement this early assessment. In this study, we summarize the state of the art and provide guidelines and recommendations on the different tests available for these early stage preclinical assessments." @default.
• W4313279519 created "2023-01-06" @default.
• W4313279519 creator A5000767918 @default.
• W4313279519 creator A5007876015 @default.
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• W4313279519 creator A5084142705 @default.
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• W4313279519 creator A5091767715 @default.
• W4313279519 date "2023-02-01" @default.
• W4313279519 modified "2023-10-17" @default.
• W4313279519 title "Considerations in the Preclinical Assessment of the Safety of Antisense Oligonucleotides" @default.
• W4313279519 cites W1573075148 @default.
• W4313279519 cites W1592986658 @default.
• W4313279519 cites W1643374506 @default.
• W4313279519 cites W1699732372 @default.
• W4313279519 cites W1755223125 @default.
• W4313279519 cites W1824984326 @default.
• W4313279519 cites W1870321215 @default.
• W4313279519 cites W1883002930 @default.
• W4313279519 cites W1891796305 @default.
• W4313279519 cites W190613024 @default.
• W4313279519 cites W1908974948 @default.
• W4313279519 cites W1917892434 @default.
• W4313279519 cites W1951507118 @default.
• W4313279519 cites W1964196894 @default.
• W4313279519 cites W1964714760 @default.
• W4313279519 cites W1965758842 @default.
• W4313279519 cites W1969072247 @default.
• W4313279519 cites W1969617808 @default.
• W4313279519 cites W1991909246 @default.
• W4313279519 cites W1997188614 @default.
• W4313279519 cites W2004232523 @default.
• W4313279519 cites W2017515700 @default.
• W4313279519 cites W2020368715 @default.
• W4313279519 cites W2024039709 @default.
• W4313279519 cites W2026934511 @default.
• W4313279519 cites W2027225984 @default.
• W4313279519 cites W2027954222 @default.
• W4313279519 cites W2033425827 @default.
• W4313279519 cites W2037695327 @default.
• W4313279519 cites W2038260132 @default.
• W4313279519 cites W2042017272 @default.
• W4313279519 cites W2047366876 @default.
• W4313279519 cites W2053716401 @default.
• W4313279519 cites W2055234488 @default.
• W4313279519 cites W2060652042 @default.
• W4313279519 cites W2069981713 @default.
• W4313279519 cites W2070832716 @default.
• W4313279519 cites W2076431356 @default.
• W4313279519 cites W2082192685 @default.
• W4313279519 cites W2083480951 @default.
• W4313279519 cites W2088707712 @default.
• W4313279519 cites W2090804804 @default.
• W4313279519 cites W2092474773 @default.
• W4313279519 cites W2094253263 @default.
• W4313279519 cites W2099515475 @default.
• W4313279519 cites W2114051020 @default.
• W4313279519 cites W2114775015 @default.
• W4313279519 cites W2118011548 @default.
• W4313279519 cites W2118019726 @default.
• W4313279519 cites W2118601234 @default.
• W4313279519 cites W2119293746 @default.
• W4313279519 cites W2120682296 @default.
• W4313279519 cites W2123034315 @default.
• W4313279519 cites W2129260942 @default.
• W4313279519 cites W2132137078 @default.
• W4313279519 cites W2141695132 @default.
• W4313279519 cites W2141754199 @default.
• W4313279519 cites W2149741786 @default.
• W4313279519 cites W2154236524 @default.
• W4313279519 cites W2155320970 @default.
• W4313279519 cites W2157668743 @default.
• W4313279519 cites W2180191687 @default.
• W4313279519 cites W2239874339 @default.
• W4313279519 cites W2242761342 @default.
• W4313279519 cites W2261840374 @default.
• W4313279519 cites W2304370660 @default.
• W4313279519 cites W2306449729 @default.
• W4313279519 cites W2347101017 @default.
• W4313279519 cites W2418558714 @default.
• W4313279519 cites W2420499553 @default.
• W4313279519 cites W2464724577 @default.
• W4313279519 cites W2473879127 @default.
• W4313279519 cites W2479276668 @default.
• W4313279519 cites W2503325479 @default.
• W4313279519 cites W2517928730 @default.
• W4313279519 cites W2567195420 @default.
• W4313279519 cites W2578121114 @default.
• W4313279519 cites W2583555090 @default.
• W4313279519 cites W2583673989 @default.
• W4313279519 cites W2593907964 @default.
• W4313279519 cites W2595169180 @default.
• W4313279519 cites W2619533159 @default.
• W4313279519 cites W2626352507 @default.
• W4313279519 cites W2626934782 @default.
• W4313279519 cites W2705639220 @default.
• W4313279519 cites W2726830914 @default.

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