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- W4313279804 abstract "Plasmablastic lymphoma (PBL) represents a rare distinct lymphoma entity with plasmablastic morphology and plasmacytic immunophenotype that is characterized by an aggressive clinical course. Standard chemotherapeutic regimens often remain insufficient to cure affected patients. Recently, comprehensive molecular analyses of large cohorts of primary PBL samples have revealed the mutational landscape as well as the pattern of copy number alterations of this rare lymphoma subtype. Identification of recurrent aberrations affecting the JAK-STAT, RAS-RAF, NOTCH, IRF4, and MYC signaling pathways drive the molecular pathogenesis of PBL and hold great potential for novel targeted therapeutic approaches." @default.
- W4313279804 created "2023-01-06" @default.
- W4313279804 creator A5016480243 @default.
- W4313279804 creator A5039142430 @default.
- W4313279804 creator A5071686136 @default.
- W4313279804 date "2022-12-28" @default.
- W4313279804 modified "2023-10-18" @default.
- W4313279804 title "Plasmablastic lymphoma: from genetics to treatment" @default.
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- W4313279804 doi "https://doi.org/10.1080/10428194.2022.2162341" @default.
- W4313279804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36577021" @default.
- W4313279804 hasPublicationYear "2022" @default.