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- W4313279819 abstract "The remarkable similarities in cognitive performance between teleosts and mammals suggest that the underlying cognitive mechanisms might also be similar in these two groups. We tested this hypothesis by assessing the effects of the brain-derived neurotrophic factor (BDNF), which is critical for mammalian cognitive functioning, on fish's cognitive abilities. We found that individual differences in zebrafish's learning abilities were positively correlated with bdnf expression. Moreover, a CRISPR/Cas9 mutant zebrafish line that lacks the BDNF gene ( bdnf −/− ) showed remarkable learning deficits. Half of the mutants failed a colour discrimination task, whereas the remaining mutants learned the task slowly, taking three times longer than control bdnf +/+ zebrafish. The mutants also took twice as long to acquire a T-maze task compared to control zebrafish and showed difficulties exerting inhibitory control. An analysis of habituation learning revealed that cognitive impairment in mutants emerges early during development, but could be rescued with a synthetic BDNF agonist. Overall, our study indicates that BDNF has a similar activational effect on cognitive performance in zebrafish and in mammals, supporting the idea that its function is conserved in vertebrates." @default.
- W4313279819 created "2023-01-06" @default.
- W4313279819 creator A5004472404 @default.
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- W4313279819 date "2022-12-21" @default.
- W4313279819 modified "2023-10-15" @default.
- W4313279819 title "Individual differences and knockout in zebrafish reveal similar cognitive effects of BDNF between teleosts and mammals" @default.
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- W4313279819 doi "https://doi.org/10.1098/rspb.2022.2036" @default.
- W4313279819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36541170" @default.
- W4313279819 hasPublicationYear "2022" @default.
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