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- W4313279995 abstract "Bullous systemic lupus erythematosus (BSLE) is a rare blistering disease in patients with SLE. BSLE is a heterogenous disease caused by autoantibodies to the basement membrane, mainly type VII collagen. The pathogenesis of the development of autoantibodies in BSLE remains unknown. We report a case of SLE taking dipeptidyl peptidase 4 inhibitors (DPP4i) who developed tense blister lesions after administration of SARS-CoV-2 vaccine. Initial erythematous lesion before administration of SARS-CoV-2 vaccine had not shown IgG deposition at basement membrane both direct and indirect immunofluorescence (IIF). However, the result of those examinations became positive after the administration of SARS-CoV-2 vaccine. Furthermore, IIF test results using NaCl split skin had shown positive against epidermal side. These observations suggest that SARS-CoV-2 vaccination triggered production of autoantibodies that cause bullous SLE. The present case fulfills the diagnostic criteria for both BSLE and DPP4i-associated bullous pemphigoid. Skin lesions were cleared after withdrawal of DPP4i. Therefore, physicians should ask patients who develop blisters after the vaccination whether they are taking DPP4i." @default.
- W4313279995 created "2023-01-06" @default.
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- W4313279995 date "2022-12-28" @default.
- W4313279995 modified "2023-09-30" @default.
- W4313279995 title "<scp>SARS‐CoV</scp>‐2 vaccine‐triggered conversion from systemic lupus erythematosus (<scp>SLE</scp>) to bullous <scp>SLE</scp> and dipeptidyl peptidase 4 inhibitors‐associated bullous pemphigoid" @default.
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- W4313279995 doi "https://doi.org/10.1111/1346-8138.16687" @default.
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