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• W4313280107 endingPage "153" @default.
• W4313280107 startingPage "141" @default.
• W4313280107 abstract "Although germline cells are considered to be functionally “immortal,” both the germline and supporting somatic cells in the gonad within an organism experience aging. With increased age at parenthood, the age-related decline in reproductive success has become an important biological issue for an aging population. However, molecular mechanisms underlying reproductive aging across sexes in vertebrates remain poorly understood. To decipher molecular drivers of vertebrate gonadal aging across sexes, we perform longitudinal characterization of the gonadal transcriptome throughout the lifespan in the naturally short-lived African turquoise killifish ( Nothobranchius furzeri ). By combining mRNA-seq and small RNA-seq from 26 individuals, we characterize the aging gonads of young-adult, middle-aged, and old female and male fish. We analyze changes in transcriptional patterns of genes, transposable elements (TEs), and piRNAs. We find that testes seem to undergo only marginal changes during aging. In contrast, in middle-aged ovaries, the time point associated with peak female fertility in this strain, PIWI pathway components are transiently down-regulated, TE transcription is elevated, and piRNA levels generally decrease, suggesting that egg quality may already be declining at middle-age. Furthermore, we show that piRNA ping-pong biogenesis declines steadily with age in ovaries, whereas it is maintained in aging testes. To our knowledge, this data set represents the most comprehensive transcriptomic data set for vertebrate gonadal aging. This resource also highlights important pathways that are regulated during reproductive aging in either ovaries or testes, which could ultimately be leveraged to help restore aspects of youthful reproductive function." @default.
• W4313280107 created "2023-01-06" @default.
• W4313280107 creator A5000409312 @default.
• W4313280107 creator A5007167006 @default.
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• W4313280107 creator A5026080595 @default.
• W4313280107 creator A5030511545 @default.
• W4313280107 creator A5052325823 @default.
• W4313280107 date "2022-12-28" @default.
• W4313280107 modified "2023-10-16" @default.
• W4313280107 title "Dynamic regulation of gonadal transposon control across the lifespan of the naturally short-lived African turquoise killifish" @default.
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• W4313280107 doi "https://doi.org/10.1101/gr.277301.122" @default.
• W4313280107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36577520" @default.
• W4313280107 hasPublicationYear "2022" @default.
• W4313280107 type Work @default.
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