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- W4313281055 abstract "The positive relationship between increased levels of circulating triglycerides and cardiovascular events has been observed for decades. Driven by genetic cohort studies, inhibitors of APOC3 (apolipoprotein C3) and ANGPTL (angiopoietin-like protein) 3 that reduce circulating triglycerides are poised to enter clinical practice. We will review the biology of how inhibition of these 2 proteins affects circulating lipoproteins as well as the current state of clinical development of monoclonal antibodies, antisense oligonucleotides, and silencing RNAs targeting APOC3 and ANGPTL3." @default.
- W4313281055 created "2023-01-06" @default.
- W4313281055 creator A5007048045 @default.
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- W4313281055 date "2023-03-01" @default.
- W4313281055 modified "2023-10-17" @default.
- W4313281055 title "Broadening the Scope of Dyslipidemia Therapy by Targeting APOC3 (Apolipoprotein C3) and ANGPTL3 (Angiopoietin-Like Protein 3)" @default.
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- W4313281055 doi "https://doi.org/10.1161/atvbaha.122.317966" @default.
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