FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313281244> ?p ?o ?g. }

• W4313281244 abstract "Background: Sepsis-induced cardiomyopathy (SIC) is a severe myocardial dysfunction secondary to septicemia. It is a major concern owing to the high mortality and morbidity, which are greatly influenced by ferroptosis. Resveratrol (RSV) is a naturally existing agonist of the silent information regulator 1 (Sirt1). It has cardioprotective effects against sepsis-induced myocardial injury, However, the detailed mechanism is unknown.Methods: In this study, cecal ligation and puncture (CLP)-induced septic rats were employed to assess the changes in ferroptosis with RSV administration. According to the different treatments the rats were divided into the following groups: (1) the Sham, (2) CLP, (3) CLP + RSV at various doses (10, 30, and 50 mg/kg), and (4) CLP + Fer-1(a ferroptotic inhibitor) groups. After 24 h, the structure and function of the cardiac system in rats were evaluated, and mitochondrial morphology, ferroptosis-related biomarkers, and the levels of Sirt1/Nrf2 were assessed.Results: The rats that underwent CLP had suffered cardiac dysfunction, accompanied with myocardial damage, impaired mitochondria, elevated lipid peroxidation, and reduced Sirt1/Nrf2 expression in the myocardium. High-dose RSV successfully improved heart function, reversing the abnormalities in a dose-dependent manner. We then used EX527, a selective Sirt1 inhibitor, to further identify the intermediate signaling targets of RSV that regulate ferroptosis. EX527 diminished the curative effects of high-doses RSV.Conclusions: Summarily, our findings suggest a novel mechanism of RSV in reducing SIC: ferroptosis inhibition via upregulation of Sirt1/Nrf2 signaling pathways. This may be an effective therapeutic approach against organ failure in sepsis, particularly SIC." @default.
• W4313281244 created "2023-01-06" @default.
• W4313281244 creator A5017039462 @default.
• W4313281244 creator A5021334632 @default.
• W4313281244 creator A5044626676 @default.
• W4313281244 creator A5056701454 @default.
• W4313281244 creator A5063954316 @default.
• W4313281244 creator A5067992824 @default.
• W4313281244 creator A5039432890 @default.
• W4313281244 creator A5043939241 @default.
• W4313281244 date "2022-12-28" @default.
• W4313281244 modified "2023-10-10" @default.
• W4313281244 title "Resveratrol Attenuates Sepsis-Induced Cardiomyopathy in Rats through Anti-Ferroptosis via the Sirt1/Nrf2 Pathway" @default.
• W4313281244 cites W1969945682 @default.
• W4313281244 cites W1977032723 @default.
• W4313281244 cites W1979504051 @default.
• W4313281244 cites W1981465323 @default.
• W4313281244 cites W1997183854 @default.
• W4313281244 cites W2010519395 @default.
• W4313281244 cites W2023945291 @default.
• W4313281244 cites W2030061880 @default.
• W4313281244 cites W2035676834 @default.
• W4313281244 cites W2056564149 @default.
• W4313281244 cites W2125408032 @default.
• W4313281244 cites W2280404143 @default.
• W4313281244 cites W2513656923 @default.
• W4313281244 cites W2573151121 @default.
• W4313281244 cites W2610035062 @default.
• W4313281244 cites W2747235741 @default.
• W4313281244 cites W2753995352 @default.
• W4313281244 cites W2791222668 @default.
• W4313281244 cites W2808829764 @default.
• W4313281244 cites W2892710900 @default.
• W4313281244 cites W2897675687 @default.
• W4313281244 cites W2909817598 @default.
• W4313281244 cites W2914574872 @default.
• W4313281244 cites W2924471609 @default.
• W4313281244 cites W2951801120 @default.
• W4313281244 cites W2968232536 @default.
• W4313281244 cites W2972712520 @default.
• W4313281244 cites W2992246536 @default.
• W4313281244 cites W3012782412 @default.
• W4313281244 cites W3021834206 @default.
• W4313281244 cites W3025324697 @default.
• W4313281244 cites W3077764649 @default.
• W4313281244 cites W3080593150 @default.
• W4313281244 cites W3094525223 @default.
• W4313281244 cites W3097853200 @default.
• W4313281244 cites W3097956554 @default.
• W4313281244 cites W3106573359 @default.
• W4313281244 cites W3112417491 @default.
• W4313281244 cites W3114365705 @default.
• W4313281244 cites W3118562156 @default.
• W4313281244 cites W3120670495 @default.
• W4313281244 cites W3121798646 @default.
• W4313281244 cites W3127958561 @default.
• W4313281244 cites W3162989398 @default.
• W4313281244 cites W3168016635 @default.
• W4313281244 cites W3183149668 @default.
• W4313281244 cites W3186763615 @default.
• W4313281244 cites W3204982646 @default.
• W4313281244 cites W4213208522 @default.
• W4313281244 cites W4213442676 @default.
• W4313281244 cites W4220982304 @default.
• W4313281244 cites W67084239 @default.
• W4313281244 cites W3015914534 @default.
• W4313281244 doi "https://doi.org/10.1080/08941939.2022.2157521" @default.
• W4313281244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36576230" @default.
• W4313281244 hasPublicationYear "2022" @default.
• W4313281244 type Work @default.
• W4313281244 citedByCount "7" @default.
• W4313281244 countsByYear W43132812442023 @default.
• W4313281244 crossrefType "journal-article" @default.
• W4313281244 hasAuthorship W4313281244A5017039462 @default.
• W4313281244 hasAuthorship W4313281244A5021334632 @default.
• W4313281244 hasAuthorship W4313281244A5039432890 @default.
• W4313281244 hasAuthorship W4313281244A5043939241 @default.
• W4313281244 hasAuthorship W4313281244A5044626676 @default.
• W4313281244 hasAuthorship W4313281244A5056701454 @default.
• W4313281244 hasAuthorship W4313281244A5063954316 @default.
• W4313281244 hasAuthorship W4313281244A5067992824 @default.
• W4313281244 hasBestOaLocation W43132812441 @default.
• W4313281244 hasConcept C104317684 @default.
• W4313281244 hasConcept C111566952 @default.
• W4313281244 hasConcept C126322002 @default.
• W4313281244 hasConcept C127561419 @default.
• W4313281244 hasConcept C185592680 @default.
• W4313281244 hasConcept C190283241 @default.
• W4313281244 hasConcept C203014093 @default.
• W4313281244 hasConcept C2776151105 @default.
• W4313281244 hasConcept C2776816829 @default.
• W4313281244 hasConcept C2778198053 @default.
• W4313281244 hasConcept C2778384902 @default.
• W4313281244 hasConcept C2778797674 @default.
• W4313281244 hasConcept C2780829032 @default.
• W4313281244 hasConcept C28859421 @default.
• W4313281244 hasConcept C55493867 @default.
• W4313281244 hasConcept C71924100 @default.
• W4313281244 hasConcept C86803240 @default.
• W4313281244 hasConcept C95444343 @default.

• next